Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.
H, Z., Y, W., C, H., R, J., Y, Z., Z, C., J, C., Y, Z., & Z, H. (2026). Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.. Chinese journal of natural medicines. https://doi.org/10.1016/S1875-5364(26)61207-1
H Z, Y W, C H, R J, Y Z, Z C, et al. Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.. Chinese journal of natural medicines. 2026; doi: 10.1016/S1875-5364(26)61207-1
H Z, Y W, C H, et al. Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.[J]. Chinese journal of natural medicines. 2026. DOI: 10.1016/S1875-5364(26)61207-1.
@article{h2026,
author = {Zeng H and Wang Y and Huang C and Jiang R and Zhang Y and Chai Z and Chi J and Zhang Y and Hu Z},
title = {Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.},
journal = {Chinese journal of natural medicines},
year = {2026},
doi = {10.1016/S1875-5364(26)61207-1},
note = {PMID: 42629117},
}
TY - JOUR AU - Zeng H AU - Wang Y AU - Huang C AU - Jiang R AU - Zhang Y AU - Chai Z AU - Chi J AU - Zhang Y AU - Hu Z TI - Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05. T2 - Chinese journal of natural medicines PY - 2026 DO - 10.1016/S1875-5364(26)61207-1 AN - PMID:42629117 ER -
Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represented two unprecedented classes of rearranged α-pyrone dimers, and compounds 5-7 were the first talarolactone-type dimers obtained as racemates. Extensive spectroscopic analysis, quantum chemical calculations, and X-ray diffraction analysis were used to determine their structures, including each enantiomer of racemic compounds 5-8 after chiral HPLC resolution. In human cardiomyocytes (AC16), compounds 1-6 and 8-9 attenuated injury caused by 24 h cold ischemia (CI) at 40 µmol·L-1. Moreover, compound 2 could improve CI-induced disruption of redox homeostasis via activation of the PI3K/AKT signaling pathway, representing the first fungal polyketide with such cardioprotective activity.