J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database.
D, Z., F, W., Y, D., & X, G. (2026). J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database.. Blood pressure. https://doi.org/10.1080/08037051.2026.2709810
D Z, F W, Y D, X G. J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database.. Blood pressure. 2026; doi: 10.1080/08037051.2026.2709810
D Z, F W, Y D, et al. J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database.[J]. Blood pressure. 2026. DOI: 10.1080/08037051.2026.2709810.
@article{d2026,
author = {Zhao D and Wang F and Ding Y and Gu X},
title = {J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database.},
journal = {Blood pressure},
year = {2026},
doi = {10.1080/08037051.2026.2709810},
note = {PMID: 42632059},
}
TY - JOUR AU - Zhao D AU - Wang F AU - Ding Y AU - Gu X TI - J‑shaped link of stress hyperglycaemia ratio with in-hospital and 1-year mortality in hypertension patients: based on the MIMIC-IV database. T2 - Blood pressure PY - 2026 DO - 10.1080/08037051.2026.2709810 AN - PMID:42632059 ER -
BACKGROUND: Stress hyperglycaemia ratio (SHR) is notably linked with unfavourable prognoses. Nevertheless, this correlation in hypertension is elusive. This paper uncovered a link of SHR with mortality in hypertension populations. METHODS: Hypertension patients in ICUs were enrolled from the MIMIC database. The outcomes assessed encompassed in-hospital and 1-year death. SHR was categorised into four groups, and its connection with mortality was assessed using Cox regression analysis. The restricted cubic spline method was leveraged to appraise the non-linear link of SHR with mortality. RESULTS: 2088 patients were enrolled, with 8.67% of in-hospital and 19.92% of 1-year mortality. As a continuous variable, each one-unit enhancement in SHR was connected with an elevation in in-hospital (HR, 1.93 [95% CI: 1.50-2.47]) and 1-year deaths (HR, 1.66 [95% CI: 1.37-2.01]); SHR as a categorical variable, the Q4 group exhibited enhanced in-hospital (HR, 3.29 [95% CI: 1.89-5.74]) and 1-year death (HR, 1.74 [95% CI: 1.29-2.35]). There was a J-shaped connection of SHR with in-hospital and 1-year deaths. CONCLUSION: SHR index can predict in-hospital and 1-year deaths in individuals with critical hypertension. Stress hyperglycaemia ratio (SHR) combines admission blood glucose with HbA1c to measure how much blood sugar rises above a person’s usual baseline level during the stress of an acute illness, rather than simply looking at a single high blood sugar reading.We studied over 2,000 patients with high blood pressure who were admitted to intensive care units, to explore whether SHR could predict their risk of dying.Patients with a higher SHR were more likely to die in the hospital and within one year after admission.The relationship between SHR and the risk of death was not a straight line. Instead, it showed a J-shaped pattern, meaning that the risk of death increased sharply once SHR went beyond a certain point.SHR may help doctors identify critically ill patients with hypertension who are at greater risk of death, even when other routine test results are available.This simple index is based on routine admission blood tests, so it can be easily calculated without any extra cost, and it could support earlier and more targeted treatment decisions for these high-risk patients.