Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.
IC, S., GC, M., AMC, M., AB, L., EF, D., RM, E., NG, C., & TV, S.F. (2026). Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.. Jornal brasileiro de nefrologia. https://doi.org/10.1590/2175-8239-JBN-2025-0222en
IC S, GC M, AMC M, AB L, EF D, RM E, et al. Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.. Jornal brasileiro de nefrologia. 2026; doi: 10.1590/2175-8239-JBN-2025-0222en
IC S, GC M, AMC M, et al. Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.[J]. Jornal brasileiro de nefrologia. 2026. DOI: 10.1590/2175-8239-JBN-2025-0222en.
@article{ic2026,
author = {Silva IC and Meneses GC and Martins AMC and Libório AB and Daher EF and Esmeraldo RM and Campos NG and Sandes-Freitas TV},
title = {Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study.},
journal = {Jornal brasileiro de nefrologia},
year = {2026},
doi = {10.1590/2175-8239-JBN-2025-0222en},
note = {PMID: 42636346},
}
TY - JOUR AU - Silva IC AU - Meneses GC AU - Martins AMC AU - Libório AB AU - Daher EF AU - Esmeraldo RM AU - Campos NG AU - Sandes-Freitas TV TI - Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study. T2 - Jornal brasileiro de nefrologia PY - 2026 DO - 10.1590/2175-8239-JBN-2025-0222en AN - PMID:42636346 ER -
OBJECTIVE: To compare pulmonary function and biomarkers of endothelial injury between hemodialysis patients with end-stage renal disease (ESRD) and kidney transplant (KT) recipients. METHODS: Cross-sectional study including 23 patients on dialysis for ≥ 24 months and 23 patients transplanted for ≥ 12 months, with a glomerular filtration rate ≥ 40 mL/min/1.73 m2, matched by sex and age. Pulmonary function was analyzed by maximal inspiratory and expiratory pressure (MIP and MEP), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and the Tiffeneau index. Endothelial damage was assessed using syndecan-1, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule (VCAM-1), and angiopoietin-2 (Ang-2). RESULTS: Both groups had poor performance in pulmonary function tests. The percentage of patients reaching the predicted MIP, MEP, FEV1, and FVC values was low and similar between groups (43.5%, 4.3%, 0%, and 17.4%, respectively). There were no differences in the observed/predicted ratios for MEP (66 ± 17%), FEV1 (60 ± 18%), and FVC (76 ± 22%), or in the Tiffeneau index (0.8 [IQR 0.6-0.9]). KT patients showed lower MIP percentages (82 ± 19 vs. 94 ± 12%; p = 0.019). In the KT group, endothelial damage was significantly inversely correlated with pulmonary function parameters, and this group had lower levels of VCAM-1 (1,589 [IQR 1,009-1827] vs 2,302 [IQR 1,642-3,540] ng/mL; p = 0.001), Ang-2 (0.17 [IQR 0.01-1.14] vs 0.75 [IQR 0.30-1.29] ng/mL; p = 0.040), and syndecan-1 (47.9 [IQR 33.1-67.8] vs 195.8 [IQR 126.9-286.8] ng/mL; p < 0.001). CONCLUSION: Despite better endothelial function, KT was not associated with superior pulmonary function, suggesting a multifactorial pathophysiology for lung impairment.