Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.
T, R., VN, B., SJ, C., HL, D., JK, F., SS, G., KJ, G., WW, H., R, P., & MJ, R. (2026). Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.. JACC. Cardiovascular interventions. https://doi.org/10.1016/j.jcin.2026.07.009
T R, VN B, SJ C, HL D, JK F, SS G, et al. Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.. JACC. Cardiovascular interventions. 2026; doi: 10.1016/j.jcin.2026.07.009
T R, VN B, SJ C, et al. Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.[J]. JACC. Cardiovascular interventions. 2026. DOI: 10.1016/j.jcin.2026.07.009.
@article{t2026,
author = {Rogers T and Bapat VN and Chetcuti SJ and Dauerman HL and Forrest JK and Goel SS and Grubb KJ and Htun WW and Puri R and Reardon MJ},
title = {Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis.},
journal = {JACC. Cardiovascular interventions},
year = {2026},
doi = {10.1016/j.jcin.2026.07.009},
note = {PMID: 42637291},
}
TY - JOUR AU - Rogers T AU - Bapat VN AU - Chetcuti SJ AU - Dauerman HL AU - Forrest JK AU - Goel SS AU - Grubb KJ AU - Htun WW AU - Puri R AU - Reardon MJ TI - Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis. T2 - JACC. Cardiovascular interventions PY - 2026 DO - 10.1016/j.jcin.2026.07.009 AN - PMID:42637291 ER -
BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) for failed transcatheter heart valves is expected to increase, but data on outcomes with self-expanding valves remain limited. OBJECTIVES: The aims of this study were to evaluate procedural, clinical, and quality-of-life outcomes following redo-TAVR using self-expanding Evolut valves and to compare these outcomes with those among a contemporary native TAVR cohort. METHODS: Outcomes after redo-TAVR with Evolut R, Evolut PRO, and Evolut PRO+ valves in the Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry were analyzed and compared with outcomes after native-valve TAVR using the same valve platform during the same study period. The primary endpoints were all-cause mortality, stroke, and readmission at 30 days and 1 year. RESULTS: Among 439 redo-TAVR patients (mean age 78.9 ± 9.8 years, 63.1% women), procedural complication rates were low. Redo-TAVR reduced transvalvular gradients at 1 year, although gradients remained modestly higher than after native TAVR (11.3 ± 6.1 mm Hg vs 8.2 ± 4.6 mm Hg; P < 0.001). After adjustment, clinical outcomes were similar between redo-TAVR and native TAVR at 30 days (mortality adjusted HR: 0.66 [95% CI: 0.39-1.13; P = 0.129]; stroke adjusted HR: 0.95 [95% CI: 0.54-1.68; P = 0.853]; readmission adjusted HR: 0.88 [95% CI: 0.65-1.20; P = 0.422]) and 1-year (mortality adjusted HR: 0.91 [95% CI: 0.72-1.15; P = 0.441]; stroke adjusted HR: 0.91 [95% CI: 0.63-1.34; P = 0.644]; readmission adjusted HR: 0.92 [95% CI: 0.76-1.13; P = 0.439]). Improvements in functional status and quality of life were observed early after redo-TAVR and were sustained through 1 year. Findings were consistent across prespecified subgroups. CONCLUSIONS: In a national registry, redo-TAVR with the Evolut platform was associated with low procedural complication rates and clinical outcomes comparable with those observed with native TAVR. These findings support redo-TAVR with Evolut as a feasible and effective treatment strategy in appropriately selected patients.