Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.
L, M., A, J., & PA, V. (2026). Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.. Interventional cardiology clinics. https://doi.org/10.1016/j.iccl.2026.06.004
L M, A J, PA V. Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.. Interventional cardiology clinics. 2026; doi: 10.1016/j.iccl.2026.06.004
L M, A J, PA V. Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.[J]. Interventional cardiology clinics. 2026. DOI: 10.1016/j.iccl.2026.06.004.
@article{l2026,
author = {Madanat L and Jabri A and Villablanca PA},
title = {Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity.},
journal = {Interventional cardiology clinics},
year = {2026},
doi = {10.1016/j.iccl.2026.06.004},
note = {PMID: 42648865},
}
TY - JOUR AU - Madanat L AU - Jabri A AU - Villablanca PA TI - Hypoattenuated Leaflet Thickening: Pathophysiology, Clinical Implications, and Its Role in Structural Valve Longevity. T2 - Interventional cardiology clinics PY - 2026 DO - 10.1016/j.iccl.2026.06.004 AN - PMID:42648865 ER -
The expansion of transcatheter aortic valve replacement (TAVR) into younger and lower-risk populations has heightened attention toward long-term valve durability. Hypoattenuated leaflet thickening (HALT), a subclinical imaging finding identified on multidetector computed tomography, has emerged as a relatively common occurrence following TAVR. It is characterized by low-attenuation, often meniscal-shaped thickening of bioprosthetic valve leaflets and may be present with or without associated reduced leaflet motion. Although frequently asymptomatic, HALT is increasingly recognized as part of a broader spectrum of leaflet thrombosis that may progress to clinically significant valve dysfunction.