Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.
B, L., AK, L., Z, G., F, M., J, W., J, Y., & SS, W. (2026). Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.. International journal of molecular sciences. https://doi.org/10.3390/ijms27167333
B L, AK L, Z G, F M, J W, J Y, et al. Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27167333
B L, AK L, Z G, et al. Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27167333.
@article{b2026,
author = {Liao B and Lee AK and Gu Z and Meng F and Wu J and Yang J and Wong SS},
title = {Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27167333},
note = {PMID: 42653337},
}
TY - JOUR AU - Liao B AU - Lee AK AU - Gu Z AU - Meng F AU - Wu J AU - Yang J AU - Wong SS TI - Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27167333 AN - PMID:42653337 ER -
Cardiac-related pain, including angina pectoris and pain accompanying myocardial infarction, remains clinically important, and existing treatments are inadequate for some patients. Animal and primary-tissue studies provide important mechanistic evidence, but species differences and limited access to patient-matched human neuro-cardiac tissue constrain translation. This review synthesizes the following separate advances relevant to future human iPSC-based cardiac-pain modeling: molecular mechanisms that may be reconstructed in vitro; platforms ranging from two-dimensional cultures to proposed sensory-innervated three-dimensional and microfluidic systems; and potential applications in target validation, patient-specific modeling, and analgesic screening. We distinguish direct human iPSC evidence from findings obtained in animal, primary-cell, cardiac-only, autonomic-neuron, or non-cardiac pain models. We also discuss maturation, standardization, and regulatory challenges. iPSC technologies may complement existing models and support mechanism-focused, patient-stratified research, but direct validation in human sensory-neuron-cardiac systems remains limited.