Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.
Z, Y., NS, P., D, M., SL, S., JC, V., OJ, M., D, F., T, A., G, W., & T, P. (2026). Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.. International journal of molecular sciences. https://doi.org/10.3390/ijms27167172
Z Y, NS P, D M, SL S, JC V, OJ M, et al. Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.. International journal of molecular sciences. 2026; doi: 10.3390/ijms27167172
Z Y, NS P, D M, et al. Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.[J]. International journal of molecular sciences. 2026. DOI: 10.3390/ijms27167172.
@article{z2026,
author = {Ye Z and Pommert NS and Meier D and Sellers SL and Voran JC and Müller OJ and Frank D and Attmann T and Warnecke G and Puehler T},
title = {Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.},
journal = {International journal of molecular sciences},
year = {2026},
doi = {10.3390/ijms27167172},
note = {PMID: 42653176},
}
TY - JOUR AU - Ye Z AU - Pommert NS AU - Meier D AU - Sellers SL AU - Voran JC AU - Müller OJ AU - Frank D AU - Attmann T AU - Warnecke G AU - Puehler T TI - Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents. T2 - International journal of molecular sciences PY - 2026 DO - 10.3390/ijms27167172 AN - PMID:42653176 ER -
Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both the potential and the limitations of this strategy. First-generation polymeric stents demonstrated feasibility but were limited by thick struts, insufficient radial strength, delayed healing, and increased scaffold thrombosis. In contrast, metallic bioresorbable platforms improved mechanical performance, but each material system still faces trade-offs between strength, degradation rate, and biological response. Transcatheter pulmonary valve replacement (TPVR) may represent a clinically meaningful setting for renewed BRS development. Patients with congenital heart disease often require repeated pulmonary valve interventions over a lifetime, and permanent metallic frames may increase cumulative implant burden and complicate future treatment. However, TPVR imposes distinct requirements, including large-diameter expansion, stable anchoring, fatigue resistance, controlled degradation, and leaflet-frame integration. This review summarizes the lessons learned from coronary BRS, discusses material considerations for TPVR-oriented stent design, and evaluates current preclinical evidence for bioresorbable and regenerative pulmonary valve platforms. Particular attention is given to magnesium-zinc alloys as a tunable material strategy for future bioresorbable TPVR frames. Although direct evidence for fully bioresorbable metallic TPVR devices remains limited, this approach provides a rational framework for next-generation pulmonary valve intervention.