Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.
M, I., H, F., O, T., YZ, K., IH, A., RK, D., & ME, S. (2026). Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.. Nigerian journal of clinical practice. https://doi.org/10.4103/njcp.njcp_808_25
M I, H F, O T, YZ K, IH A, RK D, et al. Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.. Nigerian journal of clinical practice. 2026; doi: 10.4103/njcp.njcp_808_25
M I, H F, O T, et al. Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.[J]. Nigerian journal of clinical practice. 2026. DOI: 10.4103/njcp.njcp_808_25.
@article{m2026,
author = {Incebiyik M and Fedai H and Tammo O and Kizildemir YZ and Adak IH and Duken RK and Sak ME},
title = {Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia.},
journal = {Nigerian journal of clinical practice},
year = {2026},
doi = {10.4103/njcp.njcp_808_25},
note = {PMID: 42671445},
}
TY - JOUR AU - Incebiyik M AU - Fedai H AU - Tammo O AU - Kizildemir YZ AU - Adak IH AU - Duken RK AU - Sak ME TI - Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia. T2 - Nigerian journal of clinical practice PY - 2026 DO - 10.4103/njcp.njcp_808_25 AN - PMID:42671445 ER -
BACKGROUND: Acute postpartum hypertension is common among women with preeclampsia, particularly after cesarean delivery, and is traditionally managed with intravenous (IV) antihypertensive agents. However, evidence directly comparing IV nitroglycerin-based regimens with oral-only strategies is limited. AIM: To compare the efficacy of oral-only antihypertensive therapy versus IV nitroglycerin-based regimens in achieving 24-hour blood pressure control among women with preeclampsia after cesarean delivery. METHODS: In this two-center retrospective cohort study, we included women with preeclampsia who developed acute hypertension within 24 hours after cesarean delivery. Patients were categorized into three groups: oral-only therapy, IV nitroglycerin plus oral therapy, and IV nitroglycerin-only regimens. The primary outcome was 24-hour blood pressure control (systolic <160 mmHg and diastolic <110 mmHg). Secondary outcomes included 30-day healthcare utilization and in-hospital complications. Multivariable regression models adjusted for baseline characteristics. RESULTS: All strategies achieved substantial blood pressure reduction. Rates of 24-hour control were high and comparable across groups ( P = 0.941), with no significant advantage of IV nitroglycerin over oral-only therapy after adjustment. Short-term clinical outcomes, including 30-day emergency visits ( P = 0.930) and in-hospital complications ( P = 0.810), were similar across groups. In subgroup analyses, IV nitroglycerin and oral nifedipine yielded similar hemodynamic responses. CONCLUSION: Oral-only therapy provides 24-hour blood pressure control and short-term outcomes comparable with resource-intensive IV nitroglycerin regimens. In stable postpartum patients, oral therapy can be used as first-line management.