Superior cervical gangliectomy exacerbates the aortic dissection in mice.
Z, Z., H, J., J, L., L, Y., M, C., T, J., Y, J., & B, J. (2026). Superior cervical gangliectomy exacerbates the aortic dissection in mice.. PloS one. https://doi.org/10.1371/journal.pone.0357281
Z Z, H J, J L, L Y, M C, T J, et al. Superior cervical gangliectomy exacerbates the aortic dissection in mice.. PloS one. 2026; doi: 10.1371/journal.pone.0357281
Z Z, H J, J L, et al. Superior cervical gangliectomy exacerbates the aortic dissection in mice.[J]. PloS one. 2026. DOI: 10.1371/journal.pone.0357281.
@article{z2026,
author = {Zhu Z and Jin H and Li J and Yu L and Cao M and Jiang T and Jin Y and Jiang B},
title = {Superior cervical gangliectomy exacerbates the aortic dissection in mice.},
journal = {PloS one},
year = {2026},
doi = {10.1371/journal.pone.0357281},
note = {PMID: 42678949},
}
TY - JOUR AU - Zhu Z AU - Jin H AU - Li J AU - Yu L AU - Cao M AU - Jiang T AU - Jin Y AU - Jiang B TI - Superior cervical gangliectomy exacerbates the aortic dissection in mice. T2 - PloS one PY - 2026 DO - 10.1371/journal.pone.0357281 AN - PMID:42678949 ER -
BACKGROUND: Sympathetic innervation is fundamentally required for physiological aortic homeostasis. Though it plays a vital important role in aortic function, its specific role in aortic dissection (AD) remains unclear. METHODS AND RESULTS: In this study, we explored the role of the sympathetic nervous system in AD by examining the effects of superior cervical ganglionectomy (SCGx) in mice. Using β-aminopropionitrile (BAPN) induced AD mice model at pre-lesional stage, the tyrosine hydroxylase (TH) expression, indicative of sympathetic activity, increased early in AD progression and correlated with aortic elastic lamina degradation. SCGx did not affect aortic structure within 2 weeks without BAPN treatment, but bilateral SCGx exacerbated AD severity, increasing rupture rates and tear range after BAPN and angiotensin II (AngII) treatment. CONCLUSIONS: These findings highlighted the role of sympathetic nervous system in early AD stages and suggested bilateral SCGx may negatively impact AD progression. Furthermore, we found a trend toward smooth muscle cell phenotypic transformation after implementing SCGx in AD, revealing the integrity of the SCG played a pivotal role in preserving aortic homeostasis.