Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.
JL, L., C, H., SW, L., N, N., M, S., YF, T., H, B., CC, C., YJ, S., & HC, C. (2026). Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.. Diabetes/metabolism research and reviews. https://doi.org/10.1002/dmrr.70188
JL L, C H, SW L, N N, M S, YF T, et al. Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.. Diabetes/metabolism research and reviews. 2026; doi: 10.1002/dmrr.70188
JL L, C H, SW L, et al. Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.[J]. Diabetes/metabolism research and reviews. 2026. DOI: 10.1002/dmrr.70188.
@article{jl2026,
author = {Lin JL and Hsu C and Lo SW and Nigam N and Shenoi M and Tu YF and Bhanderi H and Chen CC and Su YJ and Chang HC},
title = {Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.},
journal = {Diabetes/metabolism research and reviews},
year = {2026},
doi = {10.1002/dmrr.70188},
note = {PMID: 42274293},
}
TY - JOUR AU - Lin JL AU - Hsu C AU - Lo SW AU - Nigam N AU - Shenoi M AU - Tu YF AU - Bhanderi H AU - Chen CC AU - Su YJ AU - Chang HC TI - Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia. T2 - Diabetes/metabolism research and reviews PY - 2026 DO - 10.1002/dmrr.70188 AN - PMID:42274293 ER -
AIMS: The purpose of this paper is to compare the risk of incident type 2 diabetes mellitus (T2DM) among patients with hyperlipidaemia treated with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors versus statins and other nonstatin lipid-lowering agents. METHODS AND RESULTS: This target trial emulation study used a retrospective, propensity score-matched cohort design based on the TriNetX Global Collaborative Network. Adults (≥ 18 years) with hyperlipidaemia diagnosed between January 2015 and December 2024 were included. Patients with preexisting diabetes, malignancy, or death during follow-up were excluded. Three active-comparator analyses compared PCSK9 inhibitors with statins, ezetimibe and fenofibrates under a per-protocol framework. Propensity score matching (1:1) balanced demographics, comorbidities, BMI, lipid profiles and healthcare utilization. Incident T2DM was identified using ICD-10 codes and analysed. Multiple sensitivity analyses including intention-to-treat analysis were performed. In the main analysis model, PCSK9 inhibitor use was associated with a significantly lower risk of incident T2DM than statins (HR 0.815; 95% CI 0.764-0.869), ezetimibe (HR 0.919, 95% CI 0.867-0.974), and fenofibrates (HR 0.517; 95% CI 0.493-0.542). Findings were consistent across subgroups and sensitivity analyses. No significant difference was observed between different PCSK9 inhibitor modalities. CONCLUSIONS: In this large-scale real-world cohort, PCSK9 inhibitors were associated with a lower risk of new-onset T2DM compared with other lipid-lowering therapies, supporting their metabolic safety and clinical use in patients at risk for diabetes.