The mediating role of cardiac autonomic imbalance in the association between hypoxic burden and dyslipidemia in obstructive sleep apnea.
BACKGROUND: Obstructive sleep apnea (OSA) is associated with cardiac autonomic dysfunction and impaired lipid homeostasis. We investigated whether cardiac autonomic imbalance mediates the association ...
Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer.
BACKGROUND: Obesity is one of the primary risk factors for colorectal cancer (CRC) development, but the impact of obesity on therapeutic responses to anti-programmed cell death protein 1 (PD-1) immun...
Pentoxifylline and cardiorenal outcomes in advanced CKD with untreated dyslipidemia: a longitudinal cohort study.
BACKGROUND: Patients with advanced chronic kidney disease (CKD) and dyslipidemia are at high risk of kidney failure and cardiovascular events, yet many do not receive lipid-lowering therapy. Pentoxify...
Zexie decoction alleviates hyperlipidemia through modulation of the PPAR signaling pathway and lysophospholipid metabolism.
CONTEXT: Zexie Decoction (ZXD) is a classical traditional Chinese medicine prescription that has long been used for the treatment of hyperlipidemia. However, its material basis and underlying mechanis...
Cost-effectiveness and budget impact of ezetimibe-atorvastatin single-pill combination versus free combination in Chinese adults with hypercholesterolemia.
BACKGROUND: Hypercholesterolemia imposes a growing cardiovascular burden in China, yet low-density lipoprotein cholesterol (LDL-C) target attainment remains low. The single-pill combination (SPC) of e...
The impact of switching to tenofovir alafenamide on lipid profile and renal function in chronic hepatitis B: a retrospective cohort study.
OBJECTIVE: Tenofovir alafenamide (TAF) offers favorable renal safety compared with tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB), but its long-term metabolic effects remain unclear....
Formulation and evaluation of sustained-release pitavastatin-loaded chitosan nanoparticles for enhanced anti-hyperlipidemic activity.
BACKGROUND: Pitavastatin (PVN), a BCS class-II drug, exhibits poor aqueous solubility leading to limited oral bioavailability and therapeutic efficacy. OBJECTIVES: This study aimed to enhance the solu...
Safety of Coadministration of Continuous Infusions of Propofol and Clevidipine: A Multi-Site Retrospective Analysis.
INTRODUCTION: Patients often receive propofol for sedation and clevidipine for hypertension in the intensive care unit. Both agents are formulated as a lipid emulsion, which may increase the risk of h...
A recyclable antibody shield preserves LDL receptor homeostasis and enables durable lipid control without immune complex formation.
Soluble ligand-neutralizing antibodies are constrained by antigen excess and immune complex-associated toxicity. Here, we describe αLR-Ab, a humanized antibody that protects the low-density lipoprotei...
Effects of Hedan Tablets Combined With Simvastatin on Hyperlipidemia: Insights From Microbiomics and Metabolomics.
Simvastatin (ST) has limited long-term clinical utility due to its adverse effects. The combination of Hedan tablets and simvastatin (HST) exhibits superior lipid-lowering effects, but its mechanism r...
Hearing Loss and Modifiable Dementia Risk Factors in Adults Aged 50 Years or Older Living in Tasmania, Australia.
OBJECTIVE: This study examined the associations between hearing loss (HL) and other modifiable dementia risk factors in adults aged 50 years or older living in Tasmania and explored the effects of cor...
Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia.
Several case reports and a meta-analysis have documented significant increases in cholesterol levels among individuals following a ketogenic diet. However, the mechanistic drivers of this phenotype re...
An uncommon side effect of statins: perioral neuropathic symptoms.
A male patient in his 60s, with a history of hypertension and hyperlipidaemia, presented with a sensation of dryness, itchiness, numbness and tingling around his mouth that started after taking atorva...
Plozasiran: a small interfering RNA therapy for hypertriglyceridemia and familial chylomicronemia syndrome.
Plozasiran (Redemplo®) is a small interfering RNA that reduces hepatic production of apolipoprotein C-III and circulating triglycerides. It degrades ApoC-III mRNA and results in reduced levels of hepa...
Inclisiran-induced LDL-cholesterol reduction with and without concomitant statin therapy: a real-world analysis.
Inclisiran lowers LDL-cholesterol (LDL-C) by inhibiting hepatic PCSK9 synthesis. Whether concomitant statin therapy modifies the magnitude of inclisiran-associated LDL-C reduction in routine clinical ...
Novel triglyceride-lowering therapies to reduce the risk of acute pancreatitis in hypertriglyceridaemia: a protocol for systematic review and meta-analysis.
INTRODUCTION: Hypertriglyceridaemia is a major risk factor and rising aetiology for acute pancreatitis (AP), a condition associated with significant morbidity and mortality. Novel triglyceride-lowerin...
Plasma proteomics linking primary and secondary diseases: Insights into molecular mediation from UK Biobank data.
BACKGROUND: Diabetes, hypertension, and dyslipidemia are major risk factors for cardiovascular, neurological, renal, and pulmonary diseases, yet clinically accessible molecular mediators linking these...
A Potential Link Between Dyslipidemia and Inflammation in Patients with Schizophrenia: Insights from Sterols and HDL Profile Analysis.
Dyslipidemia and inflammation are two hallmarks of schizophrenia (SCZ), but the link between these two conditions remains elusive. We studied 40 SCZ patients and 40 age- and sex-matched healthy contro...
Freeze-Dried Poecilobdella manillensis Powder Regulates Cholesterol Homeostasis to Alleviate Hyperlipidemia.
Hyperlipidemia (HL) is a major metabolic disorder and a critical risk factor for cardiovascular diseases, closely associated with oxidative stress, inflammation, and disrupted cholesterol homeostasis....
Common genetic variants in dyslipidemia, inflammation, and angiogenesis pathways associated with diabetic nephropathy in Tunisians.
INTRODUCTION: Dyslipidemia, inflammation and angiogenesis pathways contribute to the genetic susceptibility to diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). This study investigated the...