Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.
DuJiang, Y. & GuoYou, W. (2026). Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.. Cardiovasc Res. https://doi.org/10.1093/cvr/cvag074
DuJiang Y, GuoYou W. Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.. Cardiovasc Res. 2026; doi: 10.1093/cvr/cvag074
DuJiang Y, GuoYou W. Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.[J]. Cardiovasc Res. 2026. DOI: 10.1093/cvr/cvag074.
@article{dujiang2026,
author = {Yang DuJiang and Wang GuoYou},
title = {Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.},
journal = {Cardiovasc Res},
year = {2026},
doi = {10.1093/cvr/cvag074},
note = {PMID: 41913975},
}
TY - JOUR AU - Yang DuJiang AU - Wang GuoYou TI - Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges. T2 - Cardiovasc Res PY - 2026 DO - 10.1093/cvr/cvag074 AN - PMID:41913975 ER -
This letter provides a critical analysis of the recent study by Luxán et al. (Cardiovasc Res. 2025) on the role of non-glycanated decorin in cardiac ageing. While acknowledging the importance of their findings, we identify several key areas requiring further investigation. These include: (1) the precise mechanistic origins of non-glycanated decorin accumulation in ageing endothelium; (2) the quantitative pathophysiological contribution of decorin-driven inflammation within the broader context of cardiac ageing; (3) the potential pleiotropic functions of decorin beyond inflammation; and (4) the significant translational challenges in targeting decorin-EGFR interactions. Resolving these issues is crucial for determining the therapeutic potential of modulating decorin in age-related cardiovascular pathologies.