Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.
Chao, W., Dantong, L., A, K.S., Zixun, Y., Shengyuan, H., Baldovino, G.J.R., Chunyu, L., Qiulian, Z., Meixi, Q., Jiaqi, H., Meng, W., Huiying, L., & Anthony, R. (2026). Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.. Nat Cardiovasc Res. https://doi.org/10.1038/s44161-026-00799-2
Chao W, Dantong L, A KS, Zixun Y, Shengyuan H, Baldovino GJR, et al. Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.. Nat Cardiovasc Res. 2026; doi: 10.1038/s44161-026-00799-2
Chao W, Dantong L, A KS, et al. Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.[J]. Nat Cardiovasc Res. 2026. DOI: 10.1038/s44161-026-00799-2.
@article{chao2026,
author = {Wu Chao and Li Dantong and Khetarpal Sumeet A and Yuan Zixun and Huang Shengyuan and Guerra Justin Ralph Baldovino and Li Chunyu and Zhou Qiulian and Quan Meixi and He Jiaqi and Wang Meng and Liang Huiying and Rosenzweig Anthony},
title = {Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.},
journal = {Nat Cardiovasc Res},
year = {2026},
doi = {10.1038/s44161-026-00799-2},
note = {PMID: 41927926},
}
TY - JOUR AU - Wu Chao AU - Li Dantong AU - Khetarpal Sumeet A AU - Yuan Zixun AU - Huang Shengyuan AU - Guerra Justin Ralph Baldovino AU - Li Chunyu AU - Zhou Qiulian AU - Quan Meixi AU - He Jiaqi AU - Wang Meng AU - Liang Huiying AU - Rosenzweig Anthony TI - Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease. T2 - Nat Cardiovasc Res PY - 2026 DO - 10.1038/s44161-026-00799-2 AN - PMID:41927926 ER -
Neurological complications frequently impact morbidity, mortality and quality of life in patients with cardiovascular disease, yet the biological mediators connecting cardiovascular and neurological disease are poorly understood. Here we leverage data from 53,014 individuals with plasma proteomic profiles and 50,228 with cardiac and brain magnetic resonance imaging from the UK Biobank to identify circulating proteins correlated with imaging-derived phenotypes (IDPs); 404 and 76 proteins were associated with cardiac or brain IDPs, and 37 with both. Expression analyses suggested these proteins largely originate from fibroblasts, smooth muscle cells, and macrophages in the arterial vasculature. Pathway analyses highlighted cytokine and vasculature-related processes for cardiac IDPs-associated proteins and extracellular matrix pathways in brain IDPs-associated proteins. Mendelian randomization and genetic colocalization supported causal roles for over 63% of these proteins in disease pathogenesis. Over 90% of the proposed candidates have not previously been established as clinical biomarkers or therapeutic targets and represent a catalog for further research.