[Tako-Tsubo syndrome associated with acute carbamate poisoning in Tunisia: a rare, multifactorial cardiac complication].
INTRODUCTION: Poisoning by carbamate-type anticholinesterase insecticides can result in severe clinical symptoms involving the gastrointestinal, respiratory, and neurological systems. Here, we present...
Genomic Structural Equation Modeling Reveals Shared Genetic Architecture and Pleiotropic Hub Genes of Sepsis-Induced Cardiomyopathy.
Background: Sepsis-induced cardiomyopathy (SICM) is a life-threatening complication driven by inflammatory cascades. Current genetic studies are restricted to single-trait analyses that cannot capture...
Association of SCARB1 Polymorphisms with Coronary Artery Disease Risk: A Systematic Review and Meta-Analysis.
BACKGROUND: Coronary artery disease (CAD) remains a major cause of morbidity and mortality worldwide. Variants in the lipid metabolism gene SCARB1 may influence CAD susceptibility, but existing eviden...
Membrane Oxygenation Improves Functional Myocardial Preservation and Enables Colloid-Enriched Perfusion in the Langendorff Isolated Heart Model.
Background: The Langendorff isolated heart model remains one of the most widely used experimental platforms for cardiovascular research. However, conventional bubble oxygenation is associated with sev...
Rippling muscle disease due to a CAV3 mutation with myocarditis-like presentation in an adolescent.
BACKGROUND: This case report describes a rare presentation of rippling muscle disease (RMD) due to a pathogenic CAV3 variant, manifesting with myocarditis-like cardiac involvement in an adolescent pat...
Compensatory kidney enlargement and blood pressure patterns in children with a solitary functioning kidney.
BACKGROUND: Children with a solitary functioning kidney (SFK) are at risk for hypertension and kidney injury despite compensatory renal growth. However, the relationship between compensatory enlargeme...
Murine Model for Selective Transection of Intestinal Autonomic Nerves.
Autonomic nerves comprise the sympathetic and parasympathetic systems, which act in a largely antagonistic manner to regulate diverse physiological functions. With growing interest in the roles of aut...
Cinematic Rendering of 3D Early and Late Gadolinium Enhancement Cardiac MRI: A Feasibility Demonstration.
Cinematic rendering (CR) is a physically based three-dimensional visualization technique that uses Monte Carlo path tracing with global illumination to generate photorealistic images from volumetric m...
Evaluation of the Molecular Docking of Potential Targets and the Time-Dependent Myocardial Effects of Omeprazole in Normotensive and Spontaneously Hypertensive Rats Subjected to Cardiac Ischemia and Reperfusion.
Proton pump inhibitors (PPIs) are widely prescribed for acid-related disorders and are generally considered safe for short-term use. However, increasing experimental and clinical evidence suggests pot...
Prevalence of erectile dysfunction and its associated factors among hypertensive men in Africa: a systematic review and meta-analysis.
BACKGROUND: Endothelial dysfunction and arterial stiffness are key underlying mechanisms that contribute to erectile dysfunction (ED), a common and often underdiagnosed condition among men with hypert...
Immunothrombotic Cell-Cell Communication Networks in Coronary Atherosclerosis: Critical Insights from Single-Cell and Spatial Systems Biology.
Coronary artery disease (CAD) is increasingly recognized as a thromboinflammatory disorder in which innate immune activation and coagulation are tightly coupled within the plaque microenvironment. Eme...
[Posterior Reversible Encephalopathy Syndrome in a Patient with Chronic Kidney Disease on Hemodialysis and Refractory Hypertension: Case Report].
Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological entity characterized by an acute or subacute neurological onset, typically reversible within a few days following the rem...
[Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i): A Therapeutic Revolution Beyond Diabetes. New Indications in Non-Diabetic Chronic Kidney Disease and Heart Failure].
Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2i), initially developed as hypoglycemic agents, have revolutionized the management of cardiorenal diseases due to potent organ-protective effects. Evid...
The Dual Role of VEGF in Intracerebral Haemorrhage: From Pathological Mechanisms to Therapeutic Opportunities.
An intracerebral haemorrhage (ICH) is a general type of haemorrhage in the brain, which arises due to the rupture of cerebral blood vessels. Many molecules have been investigated for their potential a...
Cardiac involvement in Behçet's syndrome: findings from a clinically driven cardiological evaluation.
OBJECTIVES: To characterize prevalence, patterns, and clinical correlates of cardiac involvement in a cohort of patients with Behçet's syndrome (BS) undergoing clinically driven cardiological assessme...
Beyond the slope: prognostic utility of the VE/VCO(2) intercept in chronic heart failure.
AIMS: Cardiopulmonary exercise testing (CPET) parameters are used for heart failure (HF) prognostication. While the ventilation to carbon dioxide production (VE/VCO2) slope ≥34 identifies high risk, p...
Routine external aortic compression versus no aortic compression in elective caesarean delivery to reduce blood loss: study protocol of a randomised controlled trial.
INTRODUCTION: External aortic compression is used to reduce excessive blood loss in childbirth. However, it has never been evaluated for the prevention of postpartum haemorrhage. This study aims to in...
Cardiopulmonary interactions during paediatric mechanical ventilation: protocol for a scoping review.
INTRODUCTION: The heart and lungs are closely linked anatomically and physiologically, sharing the thoracic cavity and jointly ensuring oxygenation and removal of carbon dioxide. With the introduction...
Effect of home-based cardiac rehabilitation on quality of life, health behaviours and cardiac anxiety in patients with coronary artery disease: findings from a single-blinded randomised controlled trial.
OBJECTIVE: To evaluate the effectiveness of a contextually developed home-based cardiac rehabilitation (HBCR) programme on heart-related quality of life (QoL), cardiac health behaviours (CHB) and card...
Prospective evaluation of atrial fibrillation-related stroke patients in rehabilitation programme (PEARL), clinical study for the 'Health virtual twins for the personalised management of stroke related to atrial fibrillation (TARGET)' project: a protocol for a prospective cohort analysis.
INTRODUCTION: Rehabilitation is recognised as a cornerstone of recovery in the stroke care pathway, and the intensity of therapy is closely related to functional recovery. However, longitudinal studie...