Deep Neural Networks for Automatic Atrial Fibrillation Detection Using Long-Term Ambulatory Electrocardiography: Retrospective Diagnostic Accuracy Study.
BACKGROUND: Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, affects 2% to 4% of the global adult population and is associated with an increased risk of stroke. Early diagnosis of AF a...
Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis.
Heart failure (HF) is a heterogeneous syndrome with diverse etiologies, yet the metabolic determinants specific to its subtype remain unclear. We performed an integrative multi-omics analysis combinin...
Comparison of effectiveness and safety of different haemostatic materials in patients undergoing transradial coronary intervention and diagnosis: a protocol for systematic review and network meta-analysis.
INTRODUCTION: Effective compression haemostasis is essential after transradial coronary procedures. However, evidence directly comparing different haemostatic materials remains limited. This study aim...
Association between miRNAs and DEFA4 in coronary artery disease.
BACKGROUND: Coronary artery disease (CAD) is a leading cause of death worldwide, caused by environmental factors and characterized by the formation of atherosclerotic plaques. Identification of novel ...
Cardiovascular Nanomedicine: Breakthroughs in Therapy-Challenges in Safety and Cardiotoxic Risks: A Comprehensive Review of Inorganic Nanoparticles.
The unique physicochemical properties of nanoparticles (NPs) have facilitated the development of targeted therapies for cardiovascular diseases (CVDs). According to World Health Organization estimates...
Effects of Low-Intensity Aaerobic Training on Cardiac Dysfunction and Myocardial Fibrosis Induced by Doxorubicin in Wistar Rats.
Doxorubicin-induced cardiotoxicity is a major limitation in cancer therapy. Physical exercise has been proposed as a non-pharmacological strategy capable of mitigating these effects through cardiovasc...
Autophagic therapeutic targeting for Doxorubicin-induced cardiomyopathy.
Autophagy has been extensively studied in a variety of pathologies, including neurological disorders, cancers, muscle diseases, aging, and cardiovascular diseases. Doxorubicin (Dox) is a potent antica...
Development and Internal Validation of a Vectorcardiography-Augmented Model for 12-Month Major Adverse Cardiovascular Events in Chronic Heart Failure.
To develop and internally validate a vectorcardiography (VCG)-augmented model for estimating 12-month major adverse cardiovascular events (MACE) in hospitalized patients with chronic heart failure (CH...
Mechanics and mechanobiology of arterial development.
Arteries serve primarily a biomechanical function. Critical insight into arterial structure, properties, and function thus derives from knowledge of mechanosensitive gene expression, associated micros...
Intraoperative relationship between the retromandibular vein and the marginal mandibular branch of the facial nerve: a prospective surgical study and literature review.
PURPOSE: To prospectively evaluate the intraoperative relationship between the retromandibular vein (RMV) and the marginal mandibular branch (MMB) or inferior facial nerve division during parotidectom...
Infrared thermography and dual-layer spectral CT for the detection of femoral vascular compromise: an experimental large animal study.
BACKGROUND: Rapid identification of vascular compromise remains a clinical challenge in the acute trauma setting. Conventional diagnostic tools such as CT angiography (CTA) and Doppler-ultrasound migh...
N-Acetylcysteine protects the developing brain in neonatal sepsis-like inflammation via a redox-neurovascular pathway.
BACKGROUND: Neonatal sepsis can disrupt brain development through oxidative stress, blood-brain barrier (BBB) dysfunction, peripheral leukocyte infiltration, and white matter injury. N-acetylcysteine ...
Fractionated stereotactic radiotherapy (fSRT) for symptomatic WHO grade 1 cavernous sinus meningiomas: long-term local control, clinical response, and toxicity outcomes.
PURPOSE: Cavernous sinus meningiomas represent a significant clinical challenge, given the high prevalence of neurological deficits and limited surgical options. Radiation therapy is often the preferr...
Skin capillary endothelial cells form a network of spatiotemporally conserved Ca(2+) activity.
Ca2+ signaling and its regulation are important for endothelial cell (EC) function and signaling. Yet, the spatiotemporal organization of Ca2+ activity and its regulation across a vascular plexus is p...
RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes.
Autosomal dominant kidney hypomagnesemia with RRAGD variants (ADKH-RRAGD) is a hereditary disorder characterized by kidney tubulopathy and dilated cardiomyopathy (DCM). RagD, encoded by the RRAGD gene...
Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue.
Dengue is an arboviral disease with major global public health impact. Its pathophysiology involves complex interactions between the virus and the host, including the immune response and the vascular ...
Returning to diving and hyperbaric exposure after pulmonary vein isolation for atrial fibrillation.
Pulmonary vein isolation (PVI) is an established rhythm-control therapy for atrial fibrillation (AF), yet the electrophysiological response of post-PVI individuals exposed to hyperbaric environments r...
Hirsutine Ameliorates High-Fat Diet-Induced Cardiomyopathy Through Promoting LRPPRC-Regulated Mitophagy via the PINK1/Parkin Axis in Mice.
Hirsutine, a potent drug-like indole alkaloid extracted from Uncaria rhynchophylla, exhibits several biological activities, including cardioprotective effects. However, the underlying regulatory mecha...
Vagal nerve stimulation (VNS) may reverse autonomic dysfunction in heart failure (HF). This paper describes results from a pivotal trial, while addressing challenges investigators face following prema...
Dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) are progressive cardiac muscle disorders with phenotypic and genetic overlap. Although a male predominance is noted in DCM/ACM, it ...