Guggulsterone Alleviates Atherosclerosis in ApoE(-/-) Mice by Modulating Lipid Metabolism and Inflammatory Responses Associated with Modulation of the Srebp2/Hmgcr Signaling Axis.

OBJECTIVE: Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by dysregulated lipid homeostasis and plaque formation. Consequently, there is an ongoing need for therapies wi...

Inflammasome-Driven Cardiac Fibrosis in Cardiometabolic Disease and Arrhythmias: Mechanisms, Biomarkers, and Therapeutic Targets.

Chronic low-grade inflammation and maladaptive extracellular matrix remodeling co-evolve across atrial fibrillation, heart failure phenotypes, diabetic cardiomyopathy, and aortic valve stenosis. Emerg...

[Multi-lead electrocardiogram atrial fibrillation detection algorithm based on multi-scale patch-based attention].

Aiming at the deficiencies of insufficient cross-domain generalization and poor rhythm sensitivity in atrial fibrillation (AF) detection from multi-lead electrocardiogram (ECG) signals, this paper pro...

[Novel framework based on multi-stage random sampling and differentiable rendering for automated three-dimensional orientation estimation of skull base foramina].

The foramen ovale and foramen rotundum of the skull base serve as critical anatomical approaches for percutaneous puncture of the trigeminal ganglion. Their three-dimensional orientation is crucial fo...

[MSCNet: Coronary artery segmentation network with multi-scale cascade encoding and dynamic spatial context enhancement].

Coronary artery segmentation is a critical step in the clinical diagnosis of coronary heart disease. To tackle segmentation breaks and false segmentation caused by the thin and complex coronary vessel...

Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity.

Studying the global distribution of the pathogenic variant c.40_42delAGA;p.(Arg14del) in the phospholamban (PLN) gene is highly important for raising awareness among healthcare providers and may help ...

N=1-studies In Statin-intolerance; Objectifying Nocebo Effects (NISONE): a study protocol for a randomised controlled trial assessing the implementability of N=1-studies to promote the use of statins.

INTRODUCTION: Lipid-lowering therapies, particularly statins, are central to the prevention of atherosclerotic cardiovascular disease. However, their effectiveness is often compromised by statin-assoc...

Primary aldosteronism.

Primary aldosteronism (PA) results from excessive aldosterone production by one or both adrenal glands and is an important cause of hypertension, leading to increased cardiovascular and renal morbidit...

Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.

INTRODUCTION: Guideline-directed medical therapy (GDMT) has been demonstrated to reduce morbidity and mortality in patients with heart failure (HF). In addition to the need for GDMT, a large number of...

Prediction of cardiac arrest in patients with heart failure in Sweden: a registry study with development of a machine learning model.

OBJECTIVE: 30-day survival after cardiac arrest is low, 12.4% and 36% for out-of-hospital and in-hospital cardiac arrest, respectively. Heart failure is a known risk condition for cardiac arrest. Impr...

Observational multicentre registry to update key interventions and new approaches with artificial intelligence for heart failure (OKINAWA-HF): a retrospective medical record-derived registry study protocol.

INTRODUCTION: The efficacy of guideline-directed medical therapy (GDMT) for heart failure has been established in clinical trials, but trial populations differ substantially from real-world clinical p...

A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives.

The outflow tract (OFT) of the heart carries blood away from the heart into the great arteries. During embryogenesis, the OFT divides to form the aorta and pulmonary trunk, creating the double circula...

Gastrodin Ameliorates Blood Pressure by Targeting the PPAR-γ/NF-κB/NLRP3 Signaling Axis in the Hypothalamic Paraventricular Nucleus.

Hypertension increases the risk for cardiovascular and cerebrovascular diseases and both its preventive and current therapeutics measures require extensive investigations. Despite that Gastrodin, a ne...

IGF-1 Inhibits the Hemodynamics‑Induced Progression of Intracranial Aneurysms by Modulating the Proliferation and Apoptosis of Vascular Smooth Muscle Cells.

Abnormal shear stress is closely linked to the progression of intracranial aneurysms (IAs) and the apoptosis of middle layer of vascular wall. Insulin-like growth factor-1 (IGF-1) is crucial for vascu...

Integrative Bioinformatics and Experimental Validation Identify LOX as a Glycolysis-Related Biomarker in Myocardial Ischemia-Reperfusion Injury.

Reprogramming of glycolytic metabolism plays a critical role in the pathogenesis of myocardial ischemia-reperfusion injury (MIRI). Although transient glycolysis activation may alleviate energy deficit...

Cellular accumulation of lipofuscin in the heart: implications in health and disease.

Lipofuscin is a subcellular pigmented granule that has long been considered a sign of wear-and-tear and aging. This granule cannot be degraded but may be diluted by cell division. In the heart, lipofu...

Prenatal and Lactational Exposure to Polystyrene Nanoplastics Induces Lipid Accumulation in Vascular Smooth Muscle Cells of Male Offspring via the MAPK/ERK/UHRF1 Signaling Pathway.

Nanoplastics (NPs) have been shown to cross the placental barrier and disrupt systemic metabolism, raising concerns about their potential impact on developmental health. Despite accumulating evidence ...

[Application prospects of the combined isolated heart perfusion and calcium transient myocardial contraction measurement techniques in cardiovascular protective mechanisms research of acupuncture].

Acupuncture has demonstrated unique potential in the treatment of cardiovascular diseases, yet its further scientific advancement and international recognition still require breakthroughs in mechanism...

[Mechanism of electroacupuncture at "Neiguan" (PC6) and "Jianshi" (PC5) in ameliorating blood-brain barrier damage in APP/PS1 mice based on the nucleus tractus solitarius-locus coeruleus neural circuit].

OBJECTIVES: To observe the role of tyrosine hydroxylase (TH)-positive neurons in the nucleus tractus solitarius (NTS) and locus coeruleus (LC) in electroacupuncture (EA)-mediated improvement of blood-...

Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy.

Heart failure (HF) affects over 64 million people worldwide causally linked to fibrotic scarring. None of the available cardiac drugs target fibrosis directly, underlining unmet clinical need for nove...