Cardiac sarcoidosis (CS) is an enigmatic disorder characterized by unexplained patchy, sterile granulomas intermixed with preserved myocardium and fibrotic regions without granuloma. CS causes arrhyth...

Transcriptomic Identification of Renin-Angiotensin System-Related Candidate Biomarkers and External Testing of a Hypertension Diagnostic Model.

This work aimed to identify candidate renin-angiotensin system (RAS)-related blood transcriptomic biomarkers associated with hypertension, construct an externally tested candidate diagnostic model, an...

Effects of Chronic Renal Insufficiency Combined with Atrial Fibrillation on Left Atrial Endothelial Function in a Beagle Model.

The co-occurrence of atrial fibrillation (AF) and renal insufficiency (RI) represents a clinically complex phenomenon with high prevalence. This study investigated the impact of chronic moderate RI co...

Clinical Utility of the TRENDS Remote Monitoring Function Integrated into a Wearable Cardioverter-Defibrillator.

BACKGROUND: Wearable cardioverter-defibrillators (WCDs) are equipped with the TRENDS remote-monitoring system, enabling continuous assessment of arrhythmias, physiological parameters, and patient-repo...

Tissue MicroRNAs in Arrhythmogenic Cardiomyopathy: A Systematic Review of Studies in Human Myocardium and Animal Models with Implications for Post-Mortem Molecular Diagnostics.

UNLABELLED: Arrhythmogenic cardiomyopathy (ACM/ARVC) is an inherited myocardial disease characterized by progressive fibro-fatty replacement, ventricular arrhythmias, and an increased risk of sudden c...

Serum Folate in Relation to Lipid Abnormalities in Community-Dwelling Adults: A Population-Based Cross-Sectional Study in Zhejiang Province, China.

Objectives: This study aimed to examine the cross-sectional associations between serum folate concentrations and four lipid abnormality subtypes among community-dwelling adults in Zhejiang Province, C...

Aortic Single-Cell Transcriptome Analysis Reveals ApoE-Isoform-Specific Influences on Vascular Disease.

The human APOE gene is polymorphic with three major alleles that encode apolipoprotein (apo) E2, apoE3, and apoE4. Both apoE2 and apoE4 are associated with increased atherosclerosis risk. This study u...

Systemic Molecular Alterations of TP53, SIRT-1, and miR-34a Expression in Atrial Fibrillation: A Prospective Exploratory Biomarker Study.

p53, miR-34a, and SIRT-1 are involved in cellular stress responses, senescence, and inflammation-processes central to the pathophysiology of atrial fibrillation (AF). In this study, circulating TP53 a...

Influence of Mitral Annular Calcification Assessed by Cardiac Computed Tomography on Procedural and Clinical Outcomes of Transcatheter Aortic Valve Implantation.

Background and Objectives: Transcatheter aortic valve implantation (TAVI) is the standard therapy for patients with severe aortic stenosis at intermediate or high surgical risk. Mitral annular calcifi...

IMMUND: A Diagnostic and Therapeutic Pipeline to Uncover the Convergence in Functional Perturbation at Early Stages of Neurodegenerative Diseases and Multiple Sclerosis Based on Protein Markers.

Neuroinflammation is a key hallmark of both neurodegenerative and neurospecific autoimmune diseases, including multiple sclerosis (MS), where immune dysregulation contributes to cellular stress, autop...

Age-Related Concentric Remodeling and Sex-Dependent Dimensional Variation in Left Ventricular Geometry: A Cardiac Magnetic Resonance Study.

BACKGROUND/OBJECTIVES: Left ventricular (LV) geometry reflects structural adaptation to aging and biological sex. While cardiac magnetic resonance (CMR) provides precise morphologic assessment, most p...

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cardiomyopathies are traditionally classified by structural and genetic phenotypes, but emerging evidence highlights chronic myocardial inflammation as a pivotal driver of disease progression across d...

PACAP and Maxadilan (PAC1 Agonist) Influence Plaque Progression, Migratory Ability, and Mitochondrial Morphology and Dynamics in Vascular Smooth Muscle Cells.

BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP) functions as an anti-atherogenic neuropeptide. Maxadilan, a PAC1 receptor agonist, offers atheroprotection by acting downstream o...

Exosomal MALAT1 from Rapid Electrical Stimulation-Treated Atrial Fibroblasts Activates Autophagy by Downregulating miR-204-5p and Upregulating LC3B.

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is strongly associated with atrial structural remodeling driven by activated cardiac fibroblasts. Autophagy has...

IUM-hybrid model for enhanced CAD diagnosis using deep learning and VS Grad-CAM visualization.

Coronary artery disease(CAD) is a serious health issue worldwide. Early identification of CAD is used to prevent several complications, such as myocardial infarction and unexpected death. In existing ...

Observation of risk perception, knowledge and behaviour related to covid-19 in heart failure patients enrolled on a telecoaching program.

BACKGROUND: Telemedical interventions have been shown to reduce mortality and morbidity and improve the quality of life of chronic heart failure (CHF) patients. During the Covid-19 pandemic remote coa...

Treatment and control of low-density lipoprotein for primary prevention in patients in Wales with and without depression: a study of whole-population electronic health records.

AIM: This study investigated the influence of depression status on lipid lowering therapy (LLT) prescribing and achievement of guideline targets for low density lipoprotein cholesterol (LDL-C) levels ...

BenchTop Validation of UNICORN Leaflet Modification Technique in Redo-Transcatheter Aortic Valve Replacement.

BACKGROUND: Coronary obstruction is a critical risk in valve-in-valve transcatheter aortic valve replacement (TAVR). The UNICORN (undermining iatrogenic coronary obstruction with radiofrequency needle...

Skin tone and diagnostic equity in contactless blood pressure screening: a prospective observational field evaluation of remote photoplethysmography in Nigeria.

OBJECTIVES: To evaluate diagnostic equity, feasibility and acceptability of a remote photoplethysmography-based blood pressure screening application among adults with darker skin tones in Nigeria. DES...

UNICORN During Transcatheter Aortic Valve Replacement in Native and Bioprosthetic Aortic Valves: A Multicenter Study.

BACKGROUND: UNICORN (undermining coronary obstruction with radiofrequency "needle") has been adopted by some operators to prevent coronary obstruction during transcatheter aortic valve replacement (TA...