Severe right heart failure following HeartMate 3 implantation in a small pediatric patient: a case report.

HeartMate 3 (HM3) has demonstrated excellent outcomes in adults, and its use in pediatric patients has recently increased. In small pediatric patients, previous studies have mainly focused on whether ...

The pro-apoptotic GZMB and anti-apoptotic HAX-1 and DAD-1 genes and gene proteins in human right auricular tissue affected by coronary heart disease and aortic valve stenosis: a pilot study.

The anti-apoptotic genes DAD-1 and HAX-1 and the pro-apoptotic GZMB gene have a significant role in the regulation of apoptosis in heart tissue. However, investigation into these genes and their prote...

Association Between Cirrhosis and Acute or Severe Limb Ischemic Events Among Hospitalizations with Peripheral Artery Disease: A National Inpatient Sample Analysis.

Background and Objectives: Acute or severe limb ischemic events are limb- and life-threatening complications of peripheral artery disease (PAD). Although cirrhosis is increasingly recognized as a syst...

Serum Uric Acid as a Cardiovascular Risk Marker: Differential Effects of Ketogenic Diet and Intermittent Fasting in Postmenopausal Women.

BACKGROUND: Serum uric acid (UA) is increasingly recognized as a cardiovascular (CV) risk factor, with evidence suggesting that CV risk may occur at levels below conventional hyperuricemia thresholds....

From Leaky Gut to a Vulnerable Brain: Obesity-Associated Gut Barrier Failure in Colorectal Cancer and Cognitive Dysfunction.

Obesity is a major risk factor for colorectal cancer (CRC) and is increasingly recognized as a contributor to cancer-related cognitive impairment; however, the mechanistic pathways linking metabolic d...

The relationship between symptomatic lower extremity peripheral artery disease with carotid artery stenosis and ischemic stroke.

OBJECTIVE: The aim of this study was to investigate the prevalence of carotid artery stenosis (CAS) in peripheral artery disease (PAD) patients requiring surgical or interventional procedures, to exam...

A Case of Severe Bradycardia Induced by Mechanical Stimulation of the Nasal Cavity Under General Anesthesia.

The trigeminocardiac reflex (TCR) is clinically defined as the sudden onset of increased parasympathetic activity resulting from stimulation of the trigeminal nerve. This reflex increases parasympathe...

Association between dietary thiamin, riboflavin and niacin intake and hypertension and increased pulse pressure: A cross-sectional study of the National Health and Nutrition Examination Survey 1999-2023.

This cross-sectional study aimed to examine the associations between total intake of 3 B vitamins (thiamin, riboflavin, niacin) and hypertension and increased pulse pressure in U.S. adults, and to exp...

Endothelial Activation Stress Index and risk of all-cause and cardiovascular mortality in early-stage cardio-renal-metabolic syndrome: A nationwide retrospective cohort study.

Endothelial dysfunction plays a central role in the pathophysiology of cardiovascular, renal, and metabolic diseases. The Endothelial Activation Stress Index (EASIX) has emerged as a promising prognos...

Cross-sectional study of mechanism of arterial pulsation amplitude modulation under ultrasound probe compression: Similarities and differences compared with the oscillometric blood pressure measurement principle.

Arterial pulsation is used to differentiate arteries from veins on ultrasound imaging. However, the mechanism by which the arterial pulsation amplitude changes when an ultrasound probe compresses the ...

"⅓ Yacoub" for correction of supravalvular aortic stenosis: valve-sparing root enlargement and ascending aorta replacement in an adult patient.

Congenital supravalvular aortic stenosis is a rare form of left ventricular outflow-tract obstruction, which is frequently associated with genetic disorders such as Williams-Beuren syndrome, despite s...

Clinical effectiveness of telepharmacy services in patients with non-communicable diseases in ambulatory care settings.

RATIONALE: Non-communicable diseases (NCDs), such as hypertension, diabetes, and asthma, require continuous medication management. However, medication adherence remains suboptimal. Telepharmacy-define...

VMP1 forms a Ca(2+) release channel essential for postnatal heartbeat.

Normal heart contraction requires synchronized calcium ion (Ca2+) release from the sarcoplasmic reticulum (SR), traditionally attributed to ryanodine receptor 2 (RyR2). Here, we identify vacuole membr...

Barriers and facilitators to digital health tool adoption for hypertension management: systematic review of qualitative studies.

OBJECTIVES: Digital health interventions (DHIs) show considerable promise in supporting hypertension self-management by promoting preventative care and self-monitoring. While their efficacy is increas...

Combined Aldosterone Synthase and SGLT2 Inhibition: A Recipe for Success in CKD with Uncontrolled Blood Pressure?

PURPOSE OF REVIEW: To evaluate the emerging role of aldosterone synthase inhibitors (ASIs) in combination with sodium-glucose cotransporter 2 (SGLT2) inhibitors for the management of uncontrolled hype...

Effect of a culturally adapted heart-healthy diet with phytosterols and/or krill oil on lipid-related outcomes in familial hypercholesterolaemia: protocol for a multicentre randomised controlled trial in Brazil.

INTRODUCTION: An affordable heart-healthy dietary approach is essential for the management of familial hypercholesterolaemia (FH); however, the optimal dietary pattern and the role of adjunctive nutri...

Ambulatory hypertension and left ventricular hypertrophy in pediatric chronic kidney disease: a systematic review and meta-analysis.

UNLABELLED: Cardiovascular disease is the leading cause of mortality in pediatric patients with chronic kidney disease (CKD). In the general pediatric population, hypertension is associated with an in...

mHealth for chronic disease management: effects on adherence in Ghanaian patients with diabetes and hypertension.

BACKGROUND: Medication non-adherence remains a major barrier to effective chronic disease management, particularly in low- and middle-income countries. In Ghana, limited access to continuous care and ...

Mechanisms of ischaemic strokes and transient ischaemic attacks despite oral anticoagulation in patients with atrial fibrillation.

AIMS: The aim of this article was to characterise the mechanisms underlying "breakthrough" ischaemic stroke (IS) or transient ischaemic attack (TIA) despite oral anticoagulation in patients with atria...

Early cardiac doppler findings and venous hemodynamic burden after combined superficial venous treatment for primary lower extremity varicose veins: an exploratory retrospective cohort study.

This study was designed to explore early postoperative cardiac Doppler findings, venous structural and hemodynamic burden in patients with primary lower extremity varicose veins (LEVVs) undergoing a c...