This study assessed cardiovascular health in women using the American Heart Association's Life's Essential 8 (LE8) score, and compared cardiovascular health across premenopausal, perimenopausal, and p...

The impact of aortic valve morphology on outcomes after transcatheter aortic valve replacement in patients with mixed aortic valve disease, characterized by the coexistence of aortic stenosis and regu...

Preterm infants with structurally normal hearts have a higher risk of developing cardiovascular disease in adulthood when compared with term infants with structurally normal hearts. A milieu of factor...

Research is warranted to identify lipidomic markers longitudinally associated with tobacco smoking and cessation and examine their associations with cardiovascular risk metrics.

Awareness and control of cardiometabolic disease risk factors remain suboptimal in the United States. Mobile health units may improve detection, particularly in socially disadvantaged urban communitie...

The extent to which diet influences cardiovascular risk in survivors of cancer is not well established. We therefore assessed how adherence to various dietary patterns relates to the development of ca...

This study aimed to explore the association between the rim sign and intraplaque hemorrhage (IPH) based on imaging-histology analysis.

Elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease. Despite available lipid-lowering therapies, lipid control remains suboptimal. Bempedoic acid offers a ...

It has long been accepted that observational analyses have an important role in evaluating use patterns and assessing the safety of different treatments, including cardiovascular devices, in clinical ...

Trends in upright seated pulmonary artery pressure (PAP) with synchronous measurement of weight, blood pressure (BP), and heart rate (HR) have not been compared prior to heart failure events (HFE) and...

Dyslipidaemia in cancer patients presents several challenges with increasing survival of cancer patients. Dyslipidaemia and cancer treatments both increase atherosclerotic cardiovascular disease (ASCV...

During the 1960s, in a pioneering way, plasmapheresis was used to treat children with homozygous familial hypercholesterolaemia (HoFH). Over the years, apheresis has evolved to increasingly selective ...

Ageing is accompanied by progressive microvascular dysfunction, a key determinant of organ performance and longevity. The molecular drivers of this process remain incompletely defined, and the mechani...

Catheter ablation of ventricular tachycardia (VT) is characterized by long procedures and frequent recurrence. Personalized image-based computational models may provide non-invasive ablation target gu...

The CASTLE-HTx trial (NCT04649801) showed that the combination of catheter ablation and guideline-directed medical therapy (GDMT) was associated with a lower likelihood of a composite of death from an...

HO-1-modified umbilical cord MSCs alleviate pulmonary arterial hypertension by reducing inflammation and endothelial dysfunction.

OBJECTIVE: To evaluate the efficacy of MSCs-HO-1 in pulmonary arterial hypertension (PAH) and explore the underlying mechanisms. METHODS: HO-1 expression and localization in lung tissues and vessels w...

Co-culturing hiPSC-cardiomyocytes and cardiac fibroblasts enhances engineered heart tissue structure and function.

BACKGROUND: Engineered heart tissues (EHTs) are widely used for cardiac disease modeling and drug screening, but their lack of multicellularity limits translational relevance. Thus, it is essential to...

ZIKV NS3 disrupts Nrf2-mediated antioxidant defense and drives vascular smooth muscle cell damage and vascular dysfunction.

Zika virus (ZIKV) infection has been linked to vascular complications, yet the basis of vascular injury after apparent clearance of circulating virus remains poorly understood. This study examined the...

Comparison of Fatty Acid Binding Protein 3 and Ankle Brachial Index for Predicting Peripheral Artery Disease Outcomes.

Background: Peripheral artery disease (PAD) impacts more than 200 million individuals globally. Despite its prevalence, management remains suboptimal, partly due to the lack of reliable blood-based bi...

More Than Myocarditis? Cardiac Involvement in Phaeochromocytoma-A Case Report.

AIMS/BACKGROUND: Phaeochromocytoma is a rare catecholamine-secreting neuroendocrine tumour arising from chromaffin cells of the adrenal medulla or from extra-adrenal paraganglionic tissue, in which ca...