GLP-1 Receptor Agonists in the Rehabilitation of Patients with Heart Failure: Mechanisms, Clinical Evidence, and Future Perspectives.
Heart failure (HF) remains associated with high morbidity and mortality, with heart failure with preserved ejection fraction (HFpEF) becoming increasingly prevalent and therapeutically challenging des...
[Chronic coronary syndrome in patients with non-obstructive coronary arteries].
Chronic coronary syndrome is a common cause of chest pain. Ischaemia with non-obstructive coronary arteries (INOCA) is underdiagnosed and more frequent in women. Patients with INOCA have a lower quali...
Impact of Coronary Artery Disease and Revascularization on Outcomes After Transcatheter Tricuspid Edge-to-Edge Repair.
BACKGROUND: Coronary artery disease (CAD) is common in patients treated for structural heart disease, but its prevalence, prognostic impact, and optimal management in patients undergoing tricuspid tra...
Predictors of Procedural and Clinical Outcomes Following Transcatheter Tricuspid Edge-to-Edge Repair: An Expert Overview.
Tricuspid transcatheter edge-to-edge repair alleviates symptoms, but survival benefit remains inconsistent. The authors conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2...
In patients with myocardial infarction (MI), no heart failure, and left ventricular ejection fraction (LVEF) ≥ 40%, the combined BETAMI-DANBLOCK trial showed that beta-blockers reduced the risk of all...
Loss-of-function variants in KCNH2, which encodes hERG, are responsible for long QT syndrome type 2 (LQT2), a major cause of sudden cardiac death. Most hERG pore-domain missense variants are associate...
Atrial fibrillation (AF) is an independent risk factor for dementia.
Heart Failure Etiology and 6-Month Cardiorenal Recovery Patterns After Early In-Hospital SGLT2 Inhibitor Initiation in HFrEF: A Prospective Real-World Cohort.
Background: SGLT2 inhibitors improve outcomes in heart failure with reduced ejection fraction (HFrEF), but whether early recovery patterns after initiation differ according to HF etiology in real-worl...
Serum Galectin-3 Levels Correlate with Reduced Vascular Reactivity in Patients with Coronary Artery Disease.
Background and Objectives: Endothelial dysfunction is essential in the development and progression of coronary artery disease (CAD) and its complications. Galectin-3 mediates inflammation and organ fi...
Functional Pathological Features and Molecular Markers in Alzheimer's Disease.
Alzheimer's disease (AD) is a neurodegenerative disorder defined not only by amyloid-β plaques and tau pathology but also by several interacting processes that drive disease progression. These include...
Current guidance recommends better low-density lipoprotein cholesterol (LDL-C) control in patients with elevated lipoprotein(a) [Lp(a)] as Lp(a) lowering therapies are unavailable. Whether risks attri...
Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.
Background/Objectives: Whether habitual dietary omega-3 fatty acid intake is reflected in circulating biomarkers of atrial fibrillation (AF)-related pathways is unclear. We assessed whether usual diet...
Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain.
Magnesium (Mg) is an essential divalent cation involved in more than 600 enzymatic reactions and plays a fundamental role in vascular, metabolic, and neural homeostasis. Although Mg is frequently disc...
Motif-Level Graph Learning Enables Interpretable Prediction of Drug-Induced QT Prolongation via Cooperative Substructural Determinants.
Drug-induced QT interval prolongation is a critical safety concern in drug development, yet accurate and mechanistically interpretable prediction from chemical structure remains challenging due to the...
Exploring the Toxicological Relationship Between Diisononyl Cyclohexane-1,2-dicarboxylate and Atherosclerosis Through Network Toxicology, Machine Learning, and Multi-Dimensional Bioinformatics.
This study integrates multidimensional computational approaches-network toxicology, machine learning, molecular docking, and molecular dynamics simulation-to systematically elucidate the toxic mechani...
Effects of Cardiomyopathic Mutations on the Cytoplasmic Tropomyosin Isoform Tpm1.7.
Tropomyosins (Tpm) are the family of actin-binding proteins encoded by four genes in humans. Missense mutations in the TPM1 gene associated with cardiomyopathies have been studied in the sarcomeric is...
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease.
Diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) are significant contributors to pulmonary hypertension (PH) due to left heart disease. Standard in vivo evaluation of r...
A Computationally Efficient Hybrid Approach for Electrocardiogram-Based Arrhythmia Prediction.
Cardiovascular diseases, especially arrhythmias, are a leading cause of death worldwide. This highlights the need for automated systems that can detect and diagnose these conditions early. This resear...
Association Between Hemoglobin Glycation Index and Coronary Artery Inflammation in Type 2 Diabetes Mellitus Based on CCTA.
Hemoglobin glycation index (HGI) is used to quantify the biological variation of hemoglobin A1c (HbA1c). The present study explored the relationship between HGI and coronary artery inflammation in pat...
Update on Investigation and Management of Dyslipidaemias and Cardiovascular Disease Risk.
Despite accounting for a quarter of all UK deaths, atherosclerotic cardiovascular disease (ASCVD) is frequently undertreated in non-specialist hospital care due to the perceived complexity of modern l...