Burden of metabolic diseases in mainland China from 1990 to 2021: results from the global burden of disease study 2021.

BACKGROUND: Within the last three decades, common metabolic diseases have become a worldwide health burden, including type 2 diabetes mellitus (T2DM), hypertension, obesity, hypercholesterolemia, and ...

High density-lipoprotein regulates liquid-liquid phase separation of heat shock protein β-1 by lncRNA HDRACA to affect vascular inflammation and atherosclerosis.

High-density lipoprotein (HDL) from healthy subjects (HDLhealthy) has anti-inflammatory effects, whereas HDL from patients with coronary artery disease (HDLCAD) is functionally impaired, which may aff...

Chain mediation effects of depressive symptoms and nutritional risk between social support and oral frailty in patients with coronary heart disease.

INTRODUCTION: Oral frailty among coronary heart disease (CHD) patients is prevalent and harmful. CHD patients have encountered serious physical and psychological health issues. Social support is a cru...

Burden of heart failure in Asian Countries from 1990 to 2021: Update from the Global Burden of Disease Study 2021.

Heart failure (HF) remains a major public health challenge in Asia, with rising prevalence and disability burden. This study analyzed data from the 2021 Global Burden of Disease study (GBD 2021) to as...

Beyond biochemistry: multiparametric ultrasound parameters and their molecular correlates in cardio-renal-metabolic syndrome.

Cardio-renal-metabolic syndrome (CRMS)-characterized by the pathological interplay of visceral adiposity, insulin resistance, chronic kidney disease, and cardiovascular disease-affects over 90% of US ...

Longitudinal changes in laboratory parameters and QTc during isavuconazole therapy in Japanese patients with hematologic malignancies.

BACKGROUND: Isavuconazole (ISCZ) is an azole antifungal with a low risk of QTc prolongation and no requirement for renal dose adjustment. However, real-world data in Asian patients remain limited. MET...

Interplay of Atrial Arrhythmia and Chronic Heart Failure: A Population-Based Analysis of Hospital Outcomes in Germany.

AIMS: Atrial fibrillation or flutter (AFl) frequently coexists with chronic heart failure (CHF), yet its impact on in-hospital outcomes in large, unselected populations remains insufficiently defined....

Surgical management of refractory massive hemoptysis from pulmonary artery pseudoaneurysm due to Streptococcus constellatus: a rare case report and literature review.

Pulmonary artery pseudoaneurysm (PAP) is a rare but potentially fatal vascular lesion resulting from focal disruption of the pulmonary arterial wall. Although hemoptysis from the pulmonary arterial sy...

Intranasal Biodegradable Nanomedicine for Epilepsy Management: Targeting the Brain Beyond the Blood-Brain Barrier.

Epilepsy is a common chronic neurological disorder characterized by recurrent, unprovoked seizures arising from abnormal neuronal hyperexcitability and hypersynchronous electrical activity within the ...

Biocompatibility Assessment of a Hybrid Material Based on Epoxy-Treated Pericardium and Polyvinyl Alcohol Cryogel in a Rat Vascular and Subcutaneous Implantation Model.

UNLABELLED: The aim of the study was to evaluate the biocompatibility of a hybrid material based on epoxy-treated bovine pericardium and cryostructured polyvinyl alcohol (PVA) after implantation into ...

Migration of Cardiac Cells: Hot Topics that have not Attracted Clinical Attention.

Cell migration plays a critical role in various physiological and pathological processes, particularly in the development and repair of cardiac diseases. It is a complex, multi-step process involving ...

Hyperlipidemia Management: Comprehensive Review and Looking Forward.

Hyperlipidemia is a major risk factor of atherosclerotic cardiovascular disease and remains a major global health concern. While statins remain the cornerstone of therapy, a subset of patients require...

Integrated transcriptomic and metabolomic analysis reveals the regulatory role of itaconic acid in inflammatory infiltration during myocardial ischemia-reperfusion injury.

BACKGROUND: Inflammatory infiltration constitutes a fundamental pathophysiological mechanism in myocardial ischemia-reperfusion (IR) injury, characterized by its role in initiating tissue damage, ampl...

Glutamate administration is associated with aggravated atherosclerosis and altered expression of RAPGEF1, OPN, and MYL7 in High-Fat Diet-Fed ApoE⁻/⁻ Mice.

OBJECTIVE: This study aims to examine whether oral glutamate administration is associated with accelerated atherosclerosis progression in high-fat diet-fed ApoE ⁻ / ⁻ mice and to identify candidate pr...

Patient perceptions and preferences during a community-based telehealth care model for moderate-to-severe hypertension in rural communities in Kenya and Uganda.

INTRODUCTION: Hypertension is a growing health concern in sub-Saharan Africa, yet access to care can be challenging, especially in rural areas. Overcoming barriers to hypertension care remains a prior...

Challenges in diagnosis of reninoma: three case reports and literature review.

BACKGROUND: Reninoma is rare and very challenging to diagnose. It is characterized by excessive renin secretion that causes severe hypertension and occurs more frequently in young females. Here, we co...

Aging-driven metabolic abnormalities remodel intercellular communication through the gut-liver-heart axis and may promote coronary artery disease: the key role of bile acid metabolism.

Coronary artery disease (CAD) remains the leading cause of cardiovascular mortality worldwide and shows a strong age-dependence that classical risk-factor models do not fully explain. A growing body o...

Nonlinear Relationship Between Lactate/Albumin Ratio and 28-Day ICU Mortality in Patients With Congestive Heart Failure: Insights Into Inflammatory and Metabolic Interplay.

BACKGROUND: Congestive heart failure (CHF) among critically ill patients is a significant cardiovascular disorder that is linked to elevated mortality rates. The lactate/albumin ratio (LAR) is a readi...

Thyroid feedback quantile-based index predicts 90-day all-cause mortality or readmission in hospitalized heart failure patients: a retrospective cohort study.

OBJECTIVE: The Thyroid Feedback Quantile-Based Index (TFQI), a recently developed indicator derived from thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels, has demonstrated prognostic ...

Organisational Impact of Remote Patient Monitoring for Heart Failure Management: A Survey of 28 Cardiology Departments and Community Practices in France.

BACKGROUND: Remote patient monitoring (RPM) for chronic heart failure (CHF) management has demonstrated clinical and economic benefits. However, data on its organisational impact remain limited, parti...