Hypertension is associated with an increased risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study.

BACKGROUND: Peritoneal dialysis-associated peritonitis (PDAP) remains a major complication of peritoneal dialysis (PD) and is a leading cause of hospitalization, technique failure, and mortality. Hype...

Polyphenols and microglial dynamics in neurodegenerative diseases: mechanistic advances and therapeutic perspectives.

Neuroinflammation plays a central role in multiple neurological and neurodegenerative disorders, including ischemic brain injury, Alzheimer's disease (AD), and Parkinson's disease (PD). Microglia, the...

RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch.

BACKGROUND: Hypertension affects around one billion adults worldwide, with abnormal glucose metabolism and vascular smooth muscle cell (VSMC) phenotype switch playing crucial roles in its pathogenesis...

Integrated Multi-Omics Analysis Identifies PDK4 and ACOT1 as Metabolic Hub Genes Associated With Myocardial Fibrosis in Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a critical pathological driver of heart failure in diabetic patients, primarily characterized by progressive myocardial fibrosis. Nevertheless, the core molecular netw...

Dynamic LVOT Obstruction as a Cause of Hemodynamic Instability in Takotsubo Syndrome.

Takotsubo syndrome (TTS) frequently presents with chest pain, ST-segment elevation, and troponin elevation, closely mimicking acute coronary syndrome, and can be complicated by acute heart failure and...

Predicting medication non-adherence using machine learning: Incorporating Complementary and Alternative Medicine (CAM) beliefs in Malaysian chronic disease patients.

Medication non-adherence among chronic disease patients remains a major contributor to poor health outcomes and medication wastage, particularly in multi-ethnic populations such as Malaysia where cult...

Accuracy of nursing diagnoses identified at admission and discharge of patients with decompensated heart failure.

PurposeTo determine the accuracy of nursing diagnoses at hospital admission and discharge for patients with heart failure (HF).MethodsThis comparative study examined the documentation in 155 medical r...

Periapical abscess precipitating diabetic ketoacidosis and reversible sepsis-induced cardiomyopathy: a case report.

BACKGROUND: Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus, most commonly precipitated by infection. Patients with diabetes are at a significantly elevated r...

"I left my country and the people I love. It gave me hypertension": a qualitative study of social support and hypertension management in refugees.

BACKGROUND: Refugees experience a disproportionately high burden of hypertension, with war-related displacement disrupting their social networks. Countries from the Middle East and North Africa (MENA)...

Interpretable machine learning for identifying determinants of high hypertension burden under extreme heat vulnerability: evidence from Maryland, USA.

Extreme heat poses increasing risks to cardiovascular health, yet fine-scale determinants of heat-related hypertension burden remain insufficiently understood. This study examines high hypertension bu...

National divergence in cardio-kidney-metabolic syndrome burden and implications for health policy: a global burden of disease analysis with projections to 2050.

BACKGROUND: The co-occurring epidemics of diabetes and obesity have increased the prevalence of Cardio-Kidney-Metabolic (CKM) syndrome. Comparative studies on long-term trends of its three core compon...

Health literacy, social support, and health activation as determinants of health-promoting behaviors in patients with chronic heart failure: a COM-B model-based path analysis.

BACKGROUND: Chronic heart failure (CHF) is a progressive and recurrent condition associated with high hospitalization rates, substantial healthcare burden, and impaired quality of life. Health-promoti...

Association of the C-reactive protein-triglyceride glucose index with microvascular obstruction and long-term prognosis in patients with acute myocardial infarction: a CMR-based study.

BACKGROUND: The clinical benefits of percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) are frequently compromised by the occurrence of microvascular obstruction (MVO). The...

Sequential tislelizumab plus bronchial arterial chemoembolization and systemic chemotherapy in advanced NSCLC with bulky tumors: efficacy and safety.

BACKGROUND: Bulky tumor (T ≥ 50 mm) significantly compromises treatment outcomes in advanced non-small cell lung cancer (NSCLC) due to excessive tumor burden. Bronchial arterial chemoembolization (BAC...

Targeting neuroimmune interactions: the therapeutic potential of kaempferol in immune-related central nervous system disorders.

Neuroinflammation is recognized as a pivotal pathological process underlying a spectrum of neurological disorders. The exploration of natural flavonoids as therapeutic agents has substantially advance...

Diabetic Atrial Cardiomyopathy: Pathogenesis, Diagnosis, Management, AI-Driven Diagnosis, and Risk Prediction.

BACKGROUND: Diabetic atrial cardiomyopathy, a component of diabetic cardiomyopathy, is increasingly recognized. However, atrial-focused mechanistic and clinical frameworks remain less developed than v...

The effect of a multimodal multicomponent Prehabilitation program in Older adults with Chronic limb-threatening Ischemia (POCI-study): A study protocol for a multicenter randomized controlled trial.

Chronic limb threatening ischemia (CLTI) in older adults is associated with severe morbidity and high mortality. The rising prevalence is largely driven by the aging population and confronts healthcar...

Risk of Peripheral Artery Disease and Venous Thromboembolism in Patients with Neuromyelitis Optic Spectrum Disorder: A Nationwide Population-Based Cohort Study.

BACKGROUND: The relationship between Neuromyelitis optica spectrum disorder (NMOSD) and specific cardiovascular outcomes, particularly macrovascular events such as peripheral artery disease (PAD) and ...

Multimorbidity patterns and their associations with demographic characteristics, behavioral factors, and urban-rural residence: A latent class analysis in the Thai population.

Multimorbidity, defined as the presence of two or more chronic conditions, is a growing public health concern. Understanding disease clustering and risk profiles is crucial for prevention and planning...

Genetic Variants in the MTHFR and WNK1 Genes and Their Contribution to Hypertension Susceptibility.

BACKGROUND: Hypertension (HTN) is a common and complex disorder influenced by multiple genetic and environmental factor, where the underlying mechanisms of its etiology remain incompletely understood ...