S100A8/S100A9 Links Diabetic Stress to Cardiac Progenitor Cell Dysfunction and Fibrotic Heart Failure: An Integrated Transcriptomic, Single-Cell, and Functional Study.
BACKGROUND: Diabetes markedly increases the risk of heart failure, yet the molecular signals connecting metabolic stress, myocardial fibrosis, and impaired cardiac repair remain incompletely understoo...
Early prediction of late-pregnancy hypertriglyceridemia in women with gestational diabetes: development and internal validation of a clinical risk model.
BACKGROUND: Women with gestational diabetes mellitus (GDM) are at high risk of developing hypertriglyceridemia (HTG) in late pregnancy, a condition associated with adverse maternal and neonatal outcom...
High-density lipoprotein cholesterol levels and prognosis in non-ischemic dilated cardiomyopathy.
BACKGROUND: Although low high-density lipoprotein cholesterol (HDL-C) is associated with poor outcomes in heart failure, its specific prognostic role in non-ischemic dilated cardiomyopathy (DCM) remai...
Cardioprotective effect of natural products on doxorubicin-induced cardiotoxicity and cardiac ischemia-reperfusion injury: A focus on ion channels modulation.
This article reviews the cardioprotective effects of natural products against doxorubicin (DOX)-induced cardiotoxicity and ischemia-reperfusion (I/R) injury, focusing on the modulation of ion channels...
Microbiota-mediated mechanisms of natural products in atherosclerosis: focus on metabolic and inflammatory pathways.
BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by lipid accumulation, endothelial dysfunction, immune dysregulation, and plaque formation. Beyond conventiona...
Association analysis of weight-adjusted waist index with hypertension and its subtypes.
BACKGROUND: Hypertension is a leading global risk factor for cardiovascular diseases, with notable regional differences in China. The weight-adjusted waist index (WWI), a novel indicator of central ob...
Association of radiation exposure and blood lipid derived indices with hypertension risk in radiation workers.
BACKGROUND: This study aimed to explore the relationships between occupational radiation exposure, serum lipid levels and hypertension, and to assess the potential intermediate role of lipid parameter...
The associations between nailfold microvascular abnormalities and systemic inflammation or Th17/Treg dysregulation in rheumatoid arthritis.
OBJECTIVES: To investigate the abnormal characteristics of nailfold microcirculation (NMC) in patients with rheumatoid arthritis (RA) and to further analyze the associations between these abnormalitie...
Effect of RAS inhibitors on retinal microvasculature in DKD using AI-based ultra-wide-field images.
BACKGROUND: Diabetic kidney disease (DKD) and diabetic retinopathy (DR) represent two major microvascular complications of diabetes mellitus (DM). Previous studies have suggested that renin-angiotensi...
The liver-brain axis, from its function to preventive therapeutic strategies in diseases.
The liver-brain axis (LBA) represents a bidirectional communication network between the liver and the central nervous system (CNS), governed by integrated neural, humoral, and immune signaling pathway...
Endothelial TGFβ signaling modulates choroidal neovascularization severity via myeloid-endothelial cell interaction.
INTRODUCTION: The blood-retinal barrier (BRB) is essential for maintaining retinal homeostasis, consequently its disruption contributes to pathological angiogenesis in diseases such as neovascular age...
Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis.
The glymphatic system (GS) functions as a critical pathway for waste clearance from the brain, facilitating soluble protein and metabolite drainage. Recently, GS dysfunction has emerged as a potential...
Protective Effects of Mussaenda pubescens Leaf Extracts Against Oxidative Stress and Dyslipidemia.
OBJECTIVE: Mussaenda pubescens (Rubiaceae) is a medicinal plant, traditionally utilized for gastrointestinal, febrile, and reproductive ailments. This study was aimed at analyzing the antioxidant capa...
Prevalence and risk factors of hypertension in rural Bangladesh: A population-based cross-sectional study.
Non-communicable diseases (NCDs), such as hypertension, are amongst the most fatal conditions afflicting people living in low- and middle-income countries (LMIC), including Bangladesh. This study addr...
Evaluating the feasibility and acceptability of home-based isometric exercise and behaviour change for the management of hypertension: The HOME-FIT study protocol.
This protocol describes a pilot randomised controlled trial that aims to assess the feasibility and acceptability of a 24-week remotely delivered home-based isometric exercise and behaviour change int...
Psychological distress in hypertension: Prevalence and links to self-care in Gonabad, Iran.
INTRODUCTION: A critical component in the hypertension management and the prevention of its life-threatening complications, is self-care. Psychological factors such as stress, anxiety and depression m...
Degree of hypertension and subclinical coronary atherosclerosis in asymptomatic individuals without cardiovascular disease.
OBJECTIVE: This study sought to evaluate the association between degree of hypertension and subclinical coronary atherosclerosis. DESIGN AND METHOD: We analyzed 7,332 asymptomatic individuals (mean ag...
Genetic Links Between Cancer and Coronary Atherosclerosis: A Mendelian Randomization Analysis.
BACKGROUND: While observational studies have indicated a potential link between cancer and coronary atherosclerosis, the relationship remains obscured by confounding factors. Elucidating a shared gene...
Triple Antithrombotic Therapy vs Dual Antiplatelet for Prevention of Left Ventricular Thrombus After Anterior Myocardial Infarction: An Updated Meta-Analysis.
PurposeTo evaluate the efficacy and safety of triple antithrombotic therapy (TT) versus dual antiplatelet therapy (DAPT) for prevention of left ventricular thrombus (LVT) following anterior myocardial...
Genetic yield of next-generation sequencing for detecting monogenic familial hypercholesterolemia in uzbek patients with coronary artery disease.
BACKGROUND: Familial hypercholesterolaemia (FH) is an inherited disorder with markedly elevated LDL-C and increased risk of premature atherosclerotic cardiovascular disease, most often caused by patho...