Innovative Management of Rhythm Disorders in Adults with Congenital Heart Disease.

Adults with congenital heart disease (ACHD) represent a rapidly growing patient population that is uniquely predisposed to rhythm disturbances. Arrhythmia mechanisms are shaped by congenital anatomy, ...

Primary Tricuspid Regurgitation in ACHD: Diagnosis and Treatment.

Primary tricuspid valve regurgitation includes congenital and acquired disorders, especially Ebstein anomaly and tricuspid valve dysplasia. Severe tricuspid regurgitation causes progressive right atri...

Single Ventricle Fontan: The Basics for General Cardiologists.

Single-ventricle physiology encompasses a heterogeneous spectrum of congenital cardiac malformations in which a single dominant ventricle supports both pulmonary and systemic circulation. Advances in ...

Lifelong Management of Right Ventricular Outflow Tract Dysfunction in Adults with Congenital Heart Disease.

Right ventricular outflow tract (RVOT) dysfunction is a common and clinically significant late complication in adults with congenital heart disease (ACHD), often after repair of conotruncal anomalies,...

MRI-Guided Magnetic Micro/Nanorobots for Precision Neurotherapeutics: From Intelligent Navigation and BBB Penetration to Clinical Translation.

The rapid advancements in nanotechnology and medical imaging have positioned magnetic resonance imaging (MRI)-guided magnetic micro/nanorobots (MNRs) as a promising platform for integrated diagnosis a...

Magnetic Nanoparticles as a Theranostic Platform in Brain Tumor Treatment: Surmounting the Bench-to-Bedside Barriers.

Malignant brain tumors, particularly glioblastoma, remain one of the greatest challenges in oncology due to their invasive nature, therapeutic resistance, and protection by the blood-brain barrier. De...

Nanomedicine for Depression: From Blood-Brain Barrier Delivery to Neuroimmune-Barrier-Plasticity Network Reprogramming.

Depression is a heterogeneous and recurrent brain disorder in which neuroinflammation, blood-brain barrier dysfunction, oxidative and mitochondrial stress, and impaired neuroplasticity interact within...

Remodeling of muscular component of the myocardial tissue depending on age, sex and cause of death.

AIM: Ageing process, as well as different pathological conditions, can induce morphological and functional changes in all tissue including those of cardiovascular system and particularly in myocardial...

Heavy metal exposure and risk of all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study.

BACKGROUND: Evidence on the association between blood metal exposure and mortality among adults with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 remains limited. We examined the associat...

Evaluating a Novel Cell-Free Preservation Solution for Human Cardiomyocyte Protection: A Proof-of-Concept Study.

BACKGROUND: Heart transplantation remains the definitive therapy for end-stage heart failure; however, its clinical impact is constrained by donor availability and preservation-associated injury. Stat...

Efficacy of combined modality conversion therapy for HCC with portal vein tumor thrombus: a retrospective cohort study.

BACKGROUND: Unresectable hepatocellular carcinoma (uHCC) patients with portal vein tumor thrombus (PVTT) have a substandard prognosis. This study elucidated whether conversion therapy can alleviate un...

Evaluation of retinal and choroidal microvasculature parameters by OCTA in patients with premature ovarian insufficiency: a prospective case control study.

OBJECTIVE: Postmenopausal cohorts show reduced vessel density on optical coherence tomography angiography (OCTA), yet OCTA data specific to premature ovarian insufficiency (POI) are lacking. We aimed ...

Couple-level dyslipidemia and embryological and cumulative pregnancy outcomes in IVF/ICSI cycles: a single-center retrospective cohort study.

BACKGROUND: Dyslipidemia is a metabolic factor associated with reproductive outcomes, but evidence on couple-level dyslipidemia in IVF/ICSI remains limited. OBJECTIVE: To investigate associations of d...

Heart failure hospitalization in patients with and without type 2 diabetes: A population-based retrospective cohort study.

PURPOSE: Type 2 diabetes mellitus (T2DM) is a common comorbidity among patients with heart failure (HF). This study aims to describe how T2DM relates to HF hospitalization patterns across demographic ...

NOX2 inhibition attenuates oxidative stress and eNOS uncoupling in pulmonary arteries of rats following simulated air diving.

Simulated diving and decompression can impair endothelial function, but the upstream oxidant sources and their relationship with endothelial nitric oxide synthase (eNOS) coupling in the pulmonary circ...

Comparing the Documentation of Phosphatidylethanol and Alcohol History in Hypertension Management in Primary Care: A Cross-Sectional Study.

Introduction/ObjectivesHazardous alcohol use is a modifiable risk factor for hypertension, yet it is often underrecognized in primary care, and the role of Phosphatidylethanol (PEth) testing in docume...

Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets.

Obesity and cardiovascular disease are major, globally prevalent, and closely interrelated health challenges. Cardiac fibrosis represents the common pathological endpoint of multiple cardiac diseases....

The gut-liver-kidney-brain axis in Wilson disease: copper speciation-flux and barrier-mediated organ crosstalk.

Wilson disease (WD) has long been framed as a hepatocentric disorder of copper accumulation. That view is now giving way to a broader model centered on the gut-liver-kidney-brain axis. In WD, copper i...

The role of the bidirectional regulatory network between immune cells and stromal cells in cardiac repair and fibrosis following myocardial infarction.

Heart failure following myocardial infarction (MI) is a major complication affecting long-term prognosis of patient, with its core pathological processes being ventricular pathological remodeling and ...

The effectiveness of motivational interviewing on self-management in older adults with hypertension and frailty: study protocol for a randomized controlled trial.

BACKGROUND: Frailty and hypertension frequently coexist in older adults, posing substantial challenges to self-management and increasing the risk of adverse outcomes. Standard health education has sho...