Validation of deep learning enabled software MetronMind to measure vertebral heart size and vertebral left atrial size in dogs.

BACKGROUND: Vertebral heart size (VHS) and vertebral left atrial size (VLAS) are objective radiographic measurements of heart and left atrial size, respectively and are associated with inter- and intr...

Varicella-zoster virus infection of the central nervous system: clinical features and proteomic analysis of cerebrospinal fluid.

OBJECTIVE: Varicella-zoster virus (VZV) involvement of the central nervous system (CNS) can cause severe complications; however, the underlying pathogenic mechanisms remain incompletely understood. Th...

Case Report: Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome with flow cytometric phenotyping before and after treatment in a patient with urothelial carcinoma.

Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS) is an uncommon immune-related adverse event (irAE) associated with the use of immune checkp...

Intensive blood pressure control in type 2 diabetes: a meta-analysis of randomized controlled trials.

BACKGROUND: Although guidelines recommend lower blood pressure targets for patients with type 2 diabetes (T2D), evidence from randomized controlled trials (RCTs) remains inconsistent regarding the bal...

The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.

BACKGROUND: The triglyceride-glucose index (TyG) and its derivatives, such as the TyG-waist-to-height ratio (TyG-WHtR), provide reliable surrogate measures for estimating insulin resistance (IR). Thei...

Effects of Positive Event Recording on Rehabilitation Outcomes in Elderly Patients with Coronary Heart Disease and Anxiety.

BACKGROUND: Elderly patients with coronary heart disease (CHD) are prone to psychological disorders during treatment. Strengthening psychological well-being can improve rehabilitation outcomes. This s...

Effects of cardiac rehabilitation on atrial fibrillation recurrence, mortality, hospitalization, and exercise capacity: a systematic review and meta-analysis.

BACKGROUND: Cardiac rehabilitation (CR) may benefit patients with atrial fibrillation (AF) in areas such as exercise capacity. However, evidence regarding its impact on AF recurrence, a key clinical o...

Meningeal immunity and "Interstitial" therapy: a new paradigm for immunotherapy in glioblastoma.

Glioblastoma (GBM) is one of the most aggressive brain tumors, and its immunotherapy faces significant challenges, including the physical barrier of the blood-brain barrier, the tumor immunosuppressiv...

Case Report: Metastatic right ventricular tumor and pulmonary embolism from cervical cancer post COVID-19 infection.

The intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix combined with pulmonary embolism is extremely rare, with mean survival less than six months. We report a case of...

Glycocalyx disruption mediates HP-PRRSV-induced microvascular endothelial dysfunction and underlies astragalus polysaccharide's antiviral efficacy.

BACKGROUND: Pulmonary microvascular endothelial cells (MVECs) are not only targets of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) but also the pivotal hub of i...

Feasibility and findings of different radiographic methods in diagnosing canine heartworm disease.

BACKGROUND: Heartworm disease (HWD) represents the pathological consequences of heartworm (HW) (Dirofilaria immitis) infection on different organs and organ systems, primarily the lungs and heart. Rad...

Transplantation of human umbilical mesenchymal stromal cells attenuates heart failure progression in a rat model.

Myocardial infarction (MI), mainly caused by coronary artery occlusion, remains a leading cause of death worldwide. Although many patients survive after emergency treatment, chronic MI often develops,...

Dexamethasone restores blood-brain barrier integrity in an in vitro heatstroke model.

Heat-related diseases and their treatments are becoming the center of focus due to global warming resulting in rising global temperatures. Heatstroke is the most hazardous condition of heat-related di...

Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways.

Immune checkpoint inhibitor (ICI)-related myocarditis is a rare but often fatal adverse event that has gained increasing attention due to the widespread clinical use of ICIs. This review explores the ...

Assessment of Renal Changes in Bardet-Biedl Syndrome with Particular Emphasis on Kidney Size, Function, and Blood Pressure Control.

INTRODUCTION: Bardet-Biedl syndrome (BBS) is a genetically heterogeneous ciliopathy characterized by obesity, retinal dystrophy, cognitive impairment, hypogonadism, and congenital renal anomalies, whi...

Integrated Mindfulness and Cardiopulmonary Rehabilitation Improves Cardiopulmonary Performance and Psychological Stress in Pulmonary Arterial Hypertension.

OBJECTIVE: To investigate the effects of mindfulness-based stress reduction (MBSR) combined with cardiopulmonary rehabilitation (CR) training on cardiopulmonary function, oxygen delivery efficiency, a...

Trends and socioeconomic-spatial inequalities in hypertension among Muslim women in India, 2015-2021: evidence from the National Family Health Surveys.

INTRODUCTION: Hypertension is a growing public health concern in India, but little is known about how socioeconomic and spatial inequalities shape hypertension risk within religious minority populatio...

Gut dysbiosis and systemic inflammation in elderly hypertensive patients with amnestic mild cognitive impairment.

INTRODUCTION: Gut microbial dysbiosis has been linked to both high blood pressure and neurodegeneration, but its involvement in hypertensive patients with amnestic mild cognitive impairment (aMCI) has...

The Systemic Immune-Inflammation Index and High-Sensitivity C-Reactive Protein to High-Density Lipoprotein Cholesterol Ratio Predict Moderate and Severe Coronary Artery Stenosis in Older Patients with Coronary Heart Disease.

OBJECTIVE: Coronary heart disease (CHD) stems from functional and organic coronary artery stenosis (CAS). This study explored associations of the systemic immune-inflammation index (SII) and high-sens...

Cardiomyocyte-derived USP20 mitigates myocardial ischemia/reperfusion injury through deubiquitinating GRP78.

UNLABELLED: Myocardial ischemia/reperfusion (I/R) injury remains a major clinical challenge characterized by cardiomyocyte loss and adverse remodeling after reperfusion. Ubiquitin-Specific Peptidase 2...