Integrating Single-Cell Transcriptomics and Mendelian Randomization to Identify RAC1 as a Causal Metabolic Driver of Pericyte Dysfunction in Systemic Sclerosis.

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and progressive fibrosis. Although microvascular injury is an inciting event and pericytes are recognized...

A systematic review and meta-analysis of randomized controlled trials on the effects of neuromuscular electrical stimulation in patients with acute heart failure.

BACKGROUND: Acute heart failure often leads to impaired physical function, high rehospitalization rates, and poor quality of life. Although exercise-based rehabilitation benefits chronic heart failure...

[Endovascular closure of a large intrahepatic portosystemic shunt in a 3-month-old infant: the first case in Uzbekistan and literature review].

Congenital portosystemic shunts (CPSS) are rare vascular anomalies with portal blood bypassing hepatic filtration and subsequent various metabolic and developmental complications. Early diagnosis and ...

[Autovenous redo carotid artery replacement for restenosis of biological prosthesis in a field hospital at the special military operation zone].

A 40-year-old men received a shrapnel wound of the neck with common carotid artery rupture on the left in 2023. Carotid artery replacement with a diepoxy-treated biological prosthesis was performed. A...

[Comprehensive left ventricular outflow tract reconstruction in hypertrophic cardiomyopathy].

OBJECTIVE: To describe the concept of comprehensive left ventricular outflow tract reconstruction based on eliminating all obstructive mechanisms. MATERIAL AND METHODS: The authors analyzed own experi...

The ARGO dataset: Annotated and delineated intracardiac electrograms of post-ischemic ventricular tachycardia.

The identification of abnormal ventricular potentials (AVPs) in intracardiac electrograms of post-ischemic ventricular tachycardia patients is challenging, and the development of automated tools is ha...

Comparative efficacy of lipid-lowering therapies on the cardio-renal-metabolic axis in diabetic kidney disease: a Bayesian network meta-analysis addressing residual CRM risk.

BACKGROUND: In diabetic kidney disease (DKD), dyslipidemia accelerates renal decline and heart failure risk, making Cardio-Renal-Metabolic (CRM) risk reduction critical. The bidirectional relationship...

Patients with type 1 diabetes mellitus and recommended low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and apolipoprotein B targets - a SwissDiab study.

BACKGROUND: Cardiovascular risk in type 1 diabetes mellitus (T1DM) is frequently underestimated in daily clinical practice. The aim was therefore to evaluate lipid management in patients with T1DM acc...

Association of the planetary health diet score with obesity, high blood pressure, dyslipidemia, and cardiometabolic risk markers: Using data from the 2016-2020 Korea National Health and Nutrition Examination Survey.

Noncommunicable diseases (NCDs) remain the leading cause of death worldwide, with unhealthy diets and insufficient physical activity as major contributing factors. The Planetary Health Diet is a susta...

Severe immune checkpoint inhibitor-induced 3M syndrome: a case report.

BACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved survival rates in various advanced cancers, including cervical cancer. However, they can induce a range of immune-related ad...

Bone marrow cellular profile in patients with diabetes: association of statin therapy with CD34+ cells.

BACKGROUNDS: Diabetes is associated with alterations in bone marrow (BM) cellularity beyond its acute and chronic complications in both type 1 and type 2 diabetes. These changes may be amplified in pa...

The role of albumin-globulin ratio in peripheral arterial disease among hypertensive adults: evidence from a large-scale multicenter study.

OBJECTIVE: With the aging population of China, a higher prevalence of peripheral arterial disease (PAD) is observed. The albumin-globulin ratio (AGR) has a certain value in predicting cardiovascular m...

Development of User-Centered Design for Screening, Referral, and Enrollment of Medicaid Adults with Hypertension in a Health Care by Food™ Pilot Study.

BACKGROUND: Food is medicine (FIM) partnerships are increasing. There are no standard practices that integrate user-centered design (UCD) in screening, referral, and enrollment process for FIM program...

Exploring the Joint Impact of METS-VF and Functional Limitation on Cardiometabolic Multimorbidity Risk.

BACKGROUND: Cardiometabolic multimorbidity (CMM) has emerged as a primary public health challenge, significantly increasing mortality risk and reducing quality of life. Although the metabolic score fo...

Preliminary identification of psychometric cut-off points for the SQoL-CHD: a cross-sectional study based on LPA and ROC analyses in a Chinese clinical sample.

OBJECTIVE: To determine psychometric cut-off points for the male and female versions of the Sexual Quality of Life Questionnaire for Coronary Heart Disease (SQoL-CHD), and to validate their effectiven...

Atherogenic index of plasma and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus: a retrospective cross-sectional study.

OBJECTIVE: This study aimed to examine the relationship between the Atherogenic Index of Plasma (AIP) and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). MET...

Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients.

BACKGROUND: This study evaluated coronary inflammation and insulin resistance (IR) using pericoronary fat attenuation index (FAI) and triglyceride-glucose (TyG) index, and assessed their associations ...

Assessing modifiable risk factors for atrial fibrillation/flutter in the young: a hybrid local-global study.

BACKGROUND: Atrial fibrillation (AF)/atrial flutter (AFL) are among the most prevalent cardiovascular diseases in the young. This study aimed to assess modifiable risk factors by integrating a global ...

Blood vessels as primary site of rejection in murine lung transplantation.

Survival after lung transplantation lags that of other solid organ transplants. Long-term survival is hampered primarily due to chronic lung allograft dysfunction (CLAD) development. It remains elusiv...

Case Report: successful non-surgical management of massive isolated tricuspid Libman-Sacks endocarditis in a pregnant patient with SLE and secondary APS.

BACKGROUND: Isolated tricuspid valve Libman-Sacks endocarditis (LSE) is extremely rare, and its occurrence during pregnancy with severe thrombocytopenia poses major diagnostic and therapeutic challeng...