Biomolecular mechanisms of cardiac amyloidosis and its cardiovascular pathological basis.
Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy most commonly caused by transthyretin (ATTR) or immunoglobulin light chain (AL) amyloid deposition in the myocardium, microvascula...
Hydrogels in Neurological Disorders: Emerging Diagnostic and Therapeutic Applications.
The clinical management of neurological disorders remains a major challenge worldwide, constrained by fundamental limitations in both diagnosis and therapy. Electroencephalography (EEG), the cornersto...
Plant-Derived Exosome-Like Nanoparticles in Neurodegenerative Diseases: From Dual Bioactive-Delivery Roles to Translational Challenges.
Neurodegenerative diseases, particularly Alzheimer's disease (AD) and related disorders, remain difficult to treat because of their multifactorial pathogenesis, limited disease-modifying therapies, an...
Nanotechnology-Driven Drug-Delivery Systems: Mechanistic Insights for Pediatric Autism Treatment in 2026.
Autism spectrum disorder (ASD) is a diverse neurodevelopmental disorder that commences in early childhood, characterized by enduring social-communication challenges, limited interests, and behavioral ...
Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO(2)max and speckle tracking echocardiography.
INTRODUCTION: Recombinant human growth hormone (r-hGH) enhances somatic growth and body composition, yet its short-term effects on aerobic capacity and myocardial function remain unclear in short-stat...
Elastin Regulates Vascular Smooth Muscle Cell Behavior During Development and in Diseases.
Elastic fibers are crucial components of the vessel wall. They modulate the elasticity of arteries to enable a stable blood supply to peripheral organs. Vascular smooth muscle cells (VSMCs) are anothe...
Clustering Analysis of Ankle-Brachial Index Related Metabolic and Body Composition Profiles Using K-Means Approach.
PURPOSE: The Ankle-brachial Index (ABI) is a non-invasive diagnostic tool used to assess peripheral perfusion disorders. However, the increasing number of clinical parameters involved in ABI assessmen...
Screening for HFpEF in pacemaker patients: Study design and protocol of the PM-HFpEF study.
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is common in older multimorbid patients and is associated with substantial morbidity and mortality. Pacemaker (PM) patients may be pa...
The immune-cardiovascular metabolic circuitry in myocardial ischemia-reperfusion injury: from metabolic signal release to spatiotemporal reprogramming.
Myocardial ischemia-reperfusion injury (MIRI) remains a major driver of infarct expansion, adverse remodeling, and poor outcomes after reperfusion therapy, yet mechanism-based treatments remain limite...
OxLDL-induced ferroptosis and pyroptosis in atherosclerosis: a mini review.
Oxidized low-density lipoprotein (oxLDL) is a central driver of inflammatory responses in atherosclerosis and triggers multiple forms of regulated cell death beyond classical apoptosis. Ferroptosis, c...
Tanzania's NCD Transition: A Comparative Analysis of Healthy Lifestyle Behaviors for Hypertension Prevention Between Rural and Urban Adults.
IntroductionHypertension remains a major public health concern in Tanzania, yet evidence on the combined adoption of healthy lifestyle behaviors across rural and urban populations remains limited. Thi...
Latent profile and associated factors of digital health literacy among patients with coronary heart disease: a cross-sectional study.
OBJECTIVE: This study aims to explore the potential characteristics and associated factors of digital health literacy among patients with coronary heart disease, and to guide targeted intervention mea...
Neurovascular coupling and energy substrate delivery in Alzheimer's disease.
The brain has exceptionally high metabolic demands and depends on a continuous supply of oxygen and glucose to maintain neuronal activity and cognitive function. Despite accounting for only about 2 % ...
Dressing-induced hemodynamic instability in patients with heart failure: Implications for nursing care.
BACKGROUND: Heart failure (HF) restricts activities of daily living, impacting prognosis and quality of life. Dressing requires sustained upper-limb movements, postural transitions, and fine-motor tas...
Starved synapses: Gut microbiome dysbiosis and its role in Alzheimer's glucose impairment.
Alzheimer's disease (AD) is increasingly recognised as a multifactorial disorder driven by metabolic, microbial, and neuroinflammatory imbalances. The study of the research results proposes that gut d...
Does resistance training make a difference to the quality of life or heart health for older adults compared to aerobic exercise? A systematic review protocol from The People's Review.
BACKGROUND: Systematic reviews bring together all the evidence on a health topic in an organised and careful way. The People's Review aims to help the public understand what systematic reviews are and...
2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TO...
Case Report: Two cases of PD-1 inhibitor-associated myocarditis with bidirectional ventricular tachycardia.
BACKGROUND: The clinical application of targeted anti-programmed cell death protein 1 (PD-1) therapy has significantly improved the prognosis of patients with various advanced malignancies. However, l...
Contribution to the pathogenesis and early diagnosis of glaucoma. A Review.
The aim of the work is to summarize recent observations on the pathogenesis of glaucoma, both from animal experiments and from clinical examinations of humans suffering from pathological intraocular p...
Myocarditis After mRNA Vaccination: A Metabolic-Innate Immune Cascade Centered on Lipid Nanoparticles.
mRNA vaccine-associated myocarditis is a rare but clinically important adverse event whose pathogenesis remains incompletely understood. Initial hypotheses focused primarily on the spike protein antig...