Integrated Bioinformatics and Experimental Validation of Post-Translational Modification-Related Biomarkers in Myocardial Ischemia-Reperfusion Injury.
Myocardial ischemia-reperfusion injury (MIRI) lacks fully established post-translational modification (PTM)-associated biomarkers. This study aimed to identify and validate PTM-related MIRI biomarkers...
Macrophage-Targeted ROS-Responsive Nanoplatform for Coordinated NF-κB and Nrf2 Modulation in Atherosclerosis Therapy.
Atherosclerosis (AS) is a progressive cardiovascular disease characterized by arterial plaque formation, macrophage-driven inflammation, and excessive accumulation of reactive oxygen species (ROS). Ho...
Adolescent intelligence and imaging-detected atherosclerosis in middle age: a population study of Swedish men.
BACKGROUND: Childhood or adolescent intelligence has been linked to major somatic diseases and premature mortality, but the underlying pathways remain unclear. The aim of this study was therefore to d...
Clinical translation and engineering challenges of soft robotic cardiac sleeves for heart failure.
Soft robotic cardiac sleeves are an emerging class of non-blood-contact mechanical circulatory support devices designed to augment myocardial function while avoiding direct interaction with blood. The...
Pseudo-heart failure in pregnancy complicated by preeclampsia: giant mediastinal teratoma with extrinsic cardiopulmonary compression.
A woman in her early 20s at 30 weeks of gestation presented with elevated blood pressure, transaminitis, progressive dyspnoea, orthopnoea, exertional chest pain and peripheral oedema, raising concern ...
Extensive spontaneous coronary artery dissection complicated by ventricular tachycardia storm and cardiogenic shock.
A healthy man in his 40s presented with acute anterolateral ST-segment elevation myocardial infarction after sudden-onset chest pain during a coughing episode. Coronary angiography and intravascular u...
Endovascular thrombectomy alone versus intravenous thrombolysis plus endovascular thrombectomy on acute basilar artery occlusion (ATTENTION IV): study protocol for a multicentre randomised controlled trial.
INTRODUCTION: The DEVT and DIRECT-MT trials showed that endovascular thrombectomy (EVT) alone is non-inferior to intravenous thrombolysis (IVT) followed by EVT in achieving 90-day functional independe...
Rare culprit and clinical dilemma: thrombolysis in a spontaneous anterior cerebral artery dissection.
Intracranial arterial dissection (IAD) is a rare cause of ischaemic stroke, with involvement of the anterior cerebral artery (ACA) being uncommon. We present the case of a woman in her mid-40s who dev...
Reperfusion Injury and Infarct Size: Why Translation has Been Difficult, and How We Move Forward.
PURPOSE OF REVIEW: To evaluate the reasons underlying the translational failure of cardioprotection in reperfused ST-elevation myocardial infarction (STEMI) and propose a framework for designing futur...
Comparative efficacy of pharmacological therapies in non-obstructive hypertrophic cardiomyopathy: a frequentist network meta-analysis.
BACKGROUND: Management of symptomatic non-obstructive hypertrophic cardiomyopathy (HCM) remains challenging, and evidence comparing pharmacological therapies is limited. While several randomized contr...
Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives.
Myocardial ischemia-reperfusion injury (MIRI) is an inevitable pathological complication following reperfusion therapy for acute myocardial infarction. Massive reactive oxygen species burst, mitochond...
Heterologous Expression, Antihypertensive Effect, and Underlying Mechanism of Sequence-Designed ACE Inhibitory Peptide YWLKP.
Rational sequence optimization is essential for transforming food-derived peptides into more potent angiotensin-converting enzyme (ACE) inhibitors. LYPVK and its sequence-designed derivative YWLKP exh...
Neochordae for robotic repair of posterior leaflet prolapse.
Resectional and non-resectional techniques are both well established in mitral valve repair. While we generally prefer resectional methods when feasible, neochordae represent an essential complementar...
Membranous Interventricular Septal Aneurysm (MVSA) as a rare potential cause of embolic stroke: a case report and literature review.
INTRODUCTION: Membranous interventricular septum aneurysm is an infrequent source of cardioembolic stroke with only a few cases reported to date. METHODS: We present a case of recurrent ischaemic stro...
[Early efficacy and safety of sotatercept in the treatment of pulmonary arterial hypertension in a Chinese population: a single-center case series analysis].
Objective: To preliminarily evaluate the efficacy and safety of sotatercept in patients with pulmonary arterial hypertension (PAH) in China. Methods: This single-center, retrospective case series anal...
Freeze-Dried Poecilobdella manillensis Powder Regulates Cholesterol Homeostasis to Alleviate Hyperlipidemia.
Hyperlipidemia (HL) is a major metabolic disorder and a critical risk factor for cardiovascular diseases, closely associated with oxidative stress, inflammation, and disrupted cholesterol homeostasis....
Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents.
Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both t...
Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging.
Central nervous system (CNS) disorders represent a significant healthcare challenge, with aging as the primary risk factor. Current clinical management remains predominantly symptomatic, as late-stage...
Serum Angiopoietin-1 and Angiopoietin-2 as Biomarkers of Pulmonary Hemodynamic Burden in COPD-Associated Pulmonary Hypertension: A Cross-Sectional Study.
Purpose: Pulmonary hypertension (PH) is a serious complication of COPD associated with worse outcomes. Reliable circulating biomarkers of pulmonary vascular involvement are lacking. Angiopoietin-1 (AN...
Human Induced Pluripotent Stem Cell-Derived Cardioids as a Model to Assess Oligonucleotide Delivery.
Oligonucleotide-based therapeutics represent a rapidly advancing class of drugs with significant potential for treating cardiovascular diseases; however, achieving efficient delivery to cardiac tissue...