Association Between Sleep Duration and Hypertension Development in Women: A Meta-Analysis.

This study examined the association between females' sleep duration and the development of hypertension (HTN). Searches were conducted in Embase, PubMed, Cochrane Library, Web of Science, CNKI, VIP, a...

Effectiveness of Continuous Levalbuterol Versus Albuterol During a National Shortage: A Retrospective Observational Cohort Study.

INTRODUCTION: Bronchospasm requiring continuous inhaled albuterol is a common reason for pediatric intensive care unit (PICU) admission. Albuterol's racemic composition may contribute to adverse effec...

Beyond Venous Inflammation: Vessel Wall Imaging of Intracranial Arteries in Neuro-Behçet's Syndrome.

BACKGROUND: Neuro-Behçet syndrome (NBS) is a heterogeneous inflammatory disorder in which venous involvement is well recognized, while intracranial arterial pathology remains insufficiently characteri...

DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults.

Hypertension in the elderly is closely associated with vascular aging, characterized by endothelial dysfunction (ED) and a progressive decline in nitric oxide (NO) bioavailability. Age-related dysfunc...

Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin II.

Pentraxin 3 (PTX3) responds rapidly to inflammatory signals. This study investigated the functional involvement of PTX3 in angiotensin II (Ang II)-mediated cardiac hypertrophy pathogenesis, with parti...

Clinical Characteristics, Treatment Response, and Prognosis Between Saddle and Non-Saddle Pulmonary Embolism in Intermediate- to High-Risk Acute Pulmonary Embolism.

OBJECTIVE: To investigate the clinical characteristics of patients with saddle pulmonary embolism (SPE) among those with intermediate- to high-risk acute pulmonary embolism (APE). STUDY DESIGN: A comp...

The Therapeutic Potential of H(2)S-Releasing Platforms in Cardiovascular Applications.

Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H...

MITF Regulates CFTR Expression to Participate in Myocardial Ischemia-Reperfusion Injury.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) remains a major clinical problem, and its regulatory mechanisms are not fully defined. This study aimed to identify key MIRI-related targets a...

Combined prediction of anthracycline-induced cardiotoxicity in patients with breast cancer using neutrophil-to-lymphocyte ratio and left atrial reservoir strain: A prospective observational study.

ObjectiveAnthracycline-related cardiotoxicity may involve systemic inflammatory responses, and the neutrophil-to-lymphocyte ratio may change during chemotherapy as a marker for inflammatory and immune...

[Severe starvation-associated hypercholesterolemia after sleeve gastrectomy and dietary intervention: a case report].

本文报道1例因重度肥胖接受袖状胃切除术的女性，术后8个月体重下降60.0 kg，继而出现血胆固醇、低密度脂蛋白胆固醇水平较术前显著升高。在排除其他病因后，对患者进行饮食干预治疗2个月，其体重从35.0 kg逐渐增至38.1 kg，血脂水平逐渐降至正常范围，在后续随访中，患者体重增至40.0 kg，血脂水平未反弹。.

From Electrical Morphology to Physiological Dynamics: Lessons From ECG Adoption for the Clinical Integration of Heart Rate Variability.

BACKGROUND: Heart rate variability (HRV) has remained a relatively finite and niche tool in cardiology despite decades of research supporting its physiological and clinical relevance. This limited ado...

Evaluating Partial Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for Battlefield Trauma: A Comparative Analysis of Commercially Available Catheters.

INTRODUCTION: Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is a minimally invasive method to control noncompressible torso hemorrhage, now integral to military damage control resu...

Heart Failure Outcome Prediction Using Artificial Intelligence-enabled Coronary Artery Calcium CT Chamber Volumetry Compared to American Heart Association PREVENT and the Agatston Score for Heart Failure Risk Stratification.

Purpose To evaluate whether artificial intelligence (AI)-derived chamber volumetry from coronary artery calcium (CAC) CT improves heart failure (HF) risk prediction. Materials and Methods This retrosp...

Mechanisms, Biomarkers and Therapeutic Implications of Neuroinflammation in Alzheimer's Disease.

Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder worldwide, affecting millions of individuals and imposing substantial socioeconomic burdens. While traditional researc...

The Association between Hypoperfused Myocardium and Systolic Function in Patients With AMI Undergoing Complete Revascularization.

BACKGROUND: Timely restoring coronary blood flow reduces mortality in acute myocardial infarction (AMI), while epicardial flow restoration is non-parallel to myocardial reperfusion. This prospective s...

In-Vitro Evaluation of HIV/SARS-CoV-2 Co-Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders.

Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from mi...

ADAMTS4 mediates LPS-induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1.

Septic cardiomyopathy is characterized by acute cardiac dysfunction, while sustained inflammatory and extracellular matrix remodeling may contribute to subsequent myocardial fibrosis and impaired card...

Impact of Leaflet Thickness on Polymeric Valve Scaffold Function and Remodeling: Assessment in a 1- and 3-Month Ovine Stented Pulmonary Valve Replacement Model.

Approaches to the structural design of tissue engineered heart valves (TEHVs) have varied broadly, ranging from material choice to microstructural and macro-scale functional characteristics. Not only ...

Screening performance of community-based assessment checklist compared with point of care screening tests to identify high-risk individuals for diabetes and hypertension in urban Mysore, India.

Background and objectives This study validates the discriminative ability of a community-based assessment checklist (CBAC) compared with other point-of-care tools for community screening to identify i...

Community health worker-led interventions for cardio-metabolic diseases in India: Evidence from a systematic review and meta-analysis.

Background and objectives Cardio-metabolic diseases are leading cause of disability-adjusted life years (DALYs) in India. Community health workers' (CHW) local proximity and contextual understanding e...