Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop inna...
Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop inna...
Long QT syndrome (LQTS) is a life-threatening genetic disorder characterized by prolonged QT intervals on electrocardiograms. Congenital forms are mostly associated with variants in the KCNQ1 and KCNH...
Interferon (IFN) alpha (IFNα) and lambda3 (IFNλ3) constitute first line responses of immunity against SARS-CoV-2 infection by increasing interferon-stimulated genes (ISGs). Prolonged IFN production ma...
Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation.
We previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to allergen exposure or to hypoxia. To evaluate th...
Lactobacilli-Fermented Chia Seeds as a Potential Anti-Hypertensive Agent.
Hypertension is a prevalent disorder that results in millions of deaths worldwide. In this regard, timely diagnosis and effective treatment are paramount for maintaining optimal blood pressure levels ...
Exploring Targets for Heart Failure Using Mendelian Randomization, Colocalization, Summary Data-based Mendelian Randomization, and Drug Prediction.
Heart failure (HF) is a prevalent cardiovascular disease that significantly impairs quality of life in its advanced stages. Despite a variety of current treatment strategies, the disease burden of HF ...
Vascular Deletion of HDAC6 Ameliorates Diabetic Retinal Microangiopathy and Diabetic Retinopathy in an Experimental Model of Type 1 Diabetes.
Diabetic retinopathy (DR) is a leading cause of vision loss among working-age adults and is characterized by progressive retinal microvascular dysfunction driven by hyperglycemia-induced inflammation ...
[Effects of exposure to ambient fine particulate matter on dyslipidemia and modifying role of dietary factors in children and adolescents in rural China].
Objective: To analyze the association between fine particulate matter (PM2.5) exposure and dyslipidemia, and the potential modifying role of dietary factors in children and adolescents in rural China....
[A study of parent-of-origin effect of single nucleotide polymorphisms of imprinted gene KCNQ1 on risk for hypertension].
Objective: To understand the potential parent-of-origin effect (POE) of imprinted gene KCNQ1 on the risk for hypertension by using a family-based design. Methods: Probands and their relatives in 9 rur...
A Mobile Health Platform for Heart Failure Self-Management: Feasibility Study on Patient Engagement, Acceptance, and Potential Health Outcomes.
BACKGROUND: Heart failure is a chronic condition that significantly impacts patients' quality of life and increases health care burden. Effective self-monitoring and lifestyle modification are essenti...
Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens.
Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative...
Machine learning-based evaluation of lipid biomarkers for cardiovascular risk prediction in chronic kidney disease: A cross-sectional study.
Chronic kidney disease (CKD) is an important public health issue globally, greatly increasing the prevalence and mortality of cardiovascular disease (CVD). Dyslipidemia is a prevalent metabolic diseas...
Transcatheter aortic valve implantation outcomes by patient age and sex in COMPARE-TAVI 1: a cohort study.
OBJECTIVES: To explore the outcomes among patients treated with TAVI (transcatheter aortic valve implantation) in the COMPARE-TAVI 1 trial by age groups and sex. DESIGN: Cohort study. SETTING: Three D...
Extreme atherogenic index of plasma (log[TG_max/HDL_min]) and prognosis in sepsis-associated acute kidney injury: A MIMIC-IV retrospective study.
Sepsis-associated acute kidney injury (SA-AKI) substantially worsens clinical outcomes, yet reliable prognostic biomarkers remain limited. Dysregulation of lipid metabolism, particularly elevated trig...
Bidirectional associations of hypertension and chronic kidney disease risks under metal exposure: A mixture exposure and exploratory decomposition analysis.
Exposure to metals is associated with an increased risk of various diseases, including hypertension and chronic kidney disease (CKD). However, the joint effects of co-exposure to multiple metals on th...
Analysis of the influence of apparent temperature on hypertension outpatient visits in Haikou city using a distributed lag nonlinear model.
This study aimed to investigate the effect of apparent temperature (AT) on hypertension outpatient visits in Haikou City and to establish a meteorological risk grade index for hypertension incidence. ...
Blood pressure improvement after stenting in an atherosclerotic renal artery stenosis patient with normal rFFR: A case report.
BACKGROUND: There is no consensus on the optimal hemodynamic assessment of renal artery stenosis patients to identify who is suitable for revascularization. Previous studies demonstrated the predictiv...
Rapid progression of cardiovascular-kidney-metabolic syndrome drives accelerated frailty trajectories: A longitudinal cohort study.
The impact of dynamic cardiovascular-kidney-metabolic (CKM) syndrome progression on longitudinal frailty trajectories remains unclear. This study investigated how rapid CKM worsening influences advers...