Renal resistance index reveals 'driving effect' of vericiguat for heart failure therapy: the possible way for guideline-directed medical therapy implementation?
BACKGROUND: Guideline-directed medical therapy (GDMT) improves outcomes in heart failure. Continuous dose titration of GDMT is mandatory to reduce heart failure morbidity and mortality. The renal resi...
Clinical congestion patterns in patients with advanced heart failure: an analysis of the HELP-HF Registry.
BACKGROUND: The impact of different clinical congestion phenotypes in advanced heart failure (HF) has not been fully investigated. We aimed to evaluate congestion patterns in patients with advanced he...
Durable ventricular assist device implantation after acute myocardial infarction: an analysis of the EUROMACS registry.
INTRODUCTION: Patients undergoing durable ventricular assist device (VAD) implantation after acute myocardial infarction (AMI) present critical surgical and clinical challenges. Data on outcomes in th...
Long-term durability of self-expandable transcatheter heart valves in bicuspid versus tricuspid aortic valve stenosis: a matched-cohort analysis.
BACKGROUND: A bicuspid aortic valve (BAV) presents unique challenges for transcatheter aortic valve implantation (TAVI), and evidence on long-term bioprosthetic durability in an BAV compared to a tric...
Midazolam-induced underestimation of mitral regurgitation severity and its pharmacological reversal with flumazenil.
BACKGROUND: Sedative agents may alter hemodynamic status and influence the echocardiographic assessment of mitral regurgitation. Although anesthesia-related underestimation of mitral regurgitation has...
From Genotype to Phenotype: Investigating SLC22A5 Variants and Their Significance in Carnitine Deficiency: A Systematic Review Study.
Primary carnitine deficiency (PCD) is an autosomal recessive disorder caused by mutations in the SLC22A5 gene, which encodes the organic cation transporter 2 (OCTN2). These mutations impair carnitine ...
Chronic Kidney Disease Frequently Observed in Adults With Spina Bifida.
OBJECTIVES: We evaluated the association between chronic kidney disease and the current and background conditions of adults with spina bifida. METHODS: Patients with spina bifida (group A, n = 34) and...
Blood Pressure Changes During Aging and Menopause Among Forager-Horticulturalists in the Bolivian Amazon.
OBJECTIVES: Cardiovascular disease (CVD) is the leading cause of death for women globally, and menopause is associated with elevated morbidity and mortality. The total impact of menopause on blood pre...
Coronary Artery Disease Prediction in Korean Patients with Familial Hypercholesterolemia: Analysis Involving Cholesterol Efflux Capacity.
PURPOSE: Patients with familial hypercholesterolemia (FH) are at high risk of coronary artery disease (CAD), and its prediction is of great clinical importance. This study aimed to identify predictors...
Prognostic Utility of the Total Body Muscle Mass in Heart Failure: Insights From the JEDI-AHF Registry.
AIM: Quantifying skeletal muscle mass is essential for patients with heart failure; however, common modalities, such as bioelectrical impedance analysis, can be distorted by fluid retention. The total...
Single Cell RNA Sequencing Reveals THBS1+CD14+ Monocyte Modulates Inflammatory Activation via NRLP3-Inflammasome in Congenital Heart Block.
Isolated congenital heart block (iCHB) is defined as atrioventricular block without structural cardiac defects, characterized by irreversible fibrosis of the cardiac conduction system. Maternal autoan...
MiR-143-3p serves as a novel biomarker for diabetic cardiomyopathy and is involved in regulating high glucose-induced cardiomyocyte injury.
ObjectiveThis work aimed to verify the value of miR-143-3p in diabetic cardiomyopathy (DCM).MethodsThe ROC curve, correlation analysis, and multivariate Logistic regression analysis assessed the diagn...
LAG3 Gene Therapy Attenuates Autoimmune Uveitis by Regulating the PI3K/Akt Signaling Pathway.
PURPOSE: Lymphocyte-activation gene 3 (LAG3) is a critical immune checkpoint molecule, yet its role and mechanisms in autoimmune uveitis remain inadequately understood. This study sought to elucidate ...
Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation.
Cushing's disease (CD), the most common endogenous Cushing's syndrome, is caused by activating mutations in the ubiquitin-specific protease 8 (USP8) gene. These mutations drive adrenocorticotropic hor...
Troponin Screening and Major Cardiovascular Adverse Events During Immune Checkpoint Inhibitor Therapy.
BACKGROUND: Troponin monitoring is recommended for the early detection of immune checkpoint inhibitor (ICI)-associated myocarditis, but its utility as a universal screening tool for all cardiovascular...
Adverse pregnancy outcomes and long-term risk of peripheral artery disease: A cohort study.
BACKGROUND: Women with adverse pregnancy outcomes have higher subsequent cardiovascular risks, but their long-term risks of peripheral artery disease (PAD) and potential causality are unclear. A bette...
Thiol-Based Neuroprotective Copolymers Acutely Restore Redox Metabolism and Mediate Vasogenic Edema in a Mouse Model of Traumatic Brain Injury.
Effective pharmaceutical interventions for treating the secondary damage associated with traumatic brain injury (TBI) are limited due to poor delivery into the brain, insufficient target engagement, a...
Endovascular Treatment of Intrahepatic Hepatic Artery Pseudoaneurysms: Safety and Efficacy According to Embolization Strategies.
Background Intrahepatic hepatic artery pseudoaneurysm (IHPA) is a rare, life-threatening vascular complication requiring prompt endovascular management, yet comparative data on embolization approaches...
Quantitative Susceptibility Mapping Shows Size-dependent Focused Ultrasound-mediated Therapeutic Delivery to Naive Brain and Gliomas in Mice.
Background Focused ultrasound US (FUS)-mediated disruption of the blood-brain barrier (BBB) and blood-tumor barrier (BTB) augments therapeutic delivery; however, relationships between dose, agent size...
TMEM87a Maintains Cardiomyocyte Integrity by Limiting Ferroptosis in Dilated Cardiomyopathy.
Dilated cardiomyopathy (DCM) is a major cause of heart failure, but the organelle-level mechanisms linking cardiomyocyte stress to maladaptive remodeling remain incompletely defined. Transmembrane pro...