Salvianolic Acid B Upregulates miR-744-5p Expression in Peripheral Blood Mononuclear Cell-Derived Extracellular Vesicles to Alleviate Uremic Cardiomyopathy.

Uremic cardiomyopathy (UCM) is a severe complication of uraemia that lacks effective treatments. The role of immune dysfunction in haemodialysis patients with UCM remains unclear. Peripheral blood mon...

[Isolation, expansion, and identification of the perivascular adipose-derived mesenchymal stem cells from rat aortas].

Objective To establish a method for isolating and expanding perivascular adipose-derived mesenchymal stem cells (PV-ADSC) from rat aortas and to provide a reliable cellular model for investigating vas...

Mavacamten's Dose-Time Dynamics and Predictive Factors in Hypertrophic Obstructive Cardiomyopathy Cardiac Remodeling.

BACKGROUND: Hypertrophic obstructive cardiomyopathy (HOCM) causes dynamic left ventricular outflow tract (LVOT) obstruction and disabling symptoms; many patients do not respond to conventional agents....

Atherogenic Index of Plasma for the Prediction of Delirium in ICU Patients: A Retrospective Cohort Study Based on the MIMIC-IV Database.

BACKGROUND: This cohort study aimed to assess the association between atherogenic index of plasma (AIP) and the risk of delirium in intensive care unit (ICU) patients. METHODS: Using the Medical Infor...

Comparative Efficacy and Safety of Clevidipine Versus Nicardipine in Hypertensive Emergencies: A Systematic Review and Meta-Analysis.

BACKGROUND: Hypertensive emergencies require prompt blood pressure reduction to prevent acute target-organ damage. Clevidipine and nicardipine are commonly used intravenous dihydropyridine calcium cha...

High-Intensity Statin Treatment Is Associated With Reduced Growth Differentiation Factor-15 in Patients With Coronary Artery Disease.

BACKGROUND: Growth differentiation factor-15 (GDF-15) is upregulated in coronary artery disease (CAD). The relationship of intensive statin therapy with circulating GDF-15 levels has not been explored...

Effect and Clinical Characteristics of Human Cytomegalovirus Infection on Vascular Inflammation in Patients With Coronary Atherosclerotic Heart Disease.

This study evaluated the impact of human cytomegalovirus (HCMV) infection on vascular inflammation and clinical characteristics in patients with coronary atherosclerotic heart disease (CHD). A total o...

Long-Term Follow-up After Percutaneous Coronary Interventions for Chronic Total Occlusions.

BACKGROUND: Percutaneous coronary interventions (PCI) for chronic total occlusions (CTO) remain challenging procedures with controversial long-term clinical benefits. METHODS: We conducted an observat...

Advanced Medical Care at Home Among Patients With Acute Heart Failure.

IMPORTANCE: Contemporary data regarding the safety and quality of acute hospital care at home for heart failure (HF) are limited. OBJECTIVE: To compare safety and quality outcomes of an advanced medic...

[Epidemiology and burden on the National Health Service of cardiomyopathy associated with transthyretin amyloidosis based on administrative health data.].

RATIONALE: This study analyses, within Italian clinical practice, the epidemiology, healthcare resource utilization, and direct costs for the National Health Service (NHS) of patients with transthyret...

Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.

Olanzapine (OLZ), a commonly prescribed atypical antipsychotic, is strongly linked to cardiometabolic disorders (CMDs) such as obesity, insulin resistance, dyslipidemia, and cardiac dysfunction. Garci...

Latent Vasculopathy of a Peripheral Pulmonary Artery in FBN1-Related Marfan Syndrome.

Marfan syndrome (MFS) is a hereditary connective tissue disorder characterized by cardiovascular and skeletal abnormalities. While cardiovascular pathology is well described, the microscopic features ...

Colchicine in coronary heart disease: from inflammatory biology to secondary prevention.

Inflammation is now recognised as a central mechanism in atherosclerosis and its clinical complications, shifting coronary heart disease management beyond exclusive lipid lowering and antithrombotic t...

Network and Pairwise Meta-Analysis of the Association Between Novel Hypoglycemic Agents and Atrial Fibrillation Risk in Patients With Type 2 Diabetes Mellitus.

OBJECTIVE: To evaluate the atrial fibrillation (AF) risk of sodium-glucose cotransporter-2 inhibitors (SGLT-2i), glucagonlike peptide-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase-4 inhibitor...

Quantitative Analysis of the Heart Development of Podocnemis unifilis (Podocnemididae, Testudines): A Stereology Study.

The present study investigated the cardiac development of the Amazonian turtle Podocnemis unifilis during its embryonic phase, from the 5th to the 59th day of incubation, with emphasis on the volumetr...

Inflammation and atherosclerotic cardiovascular disease: lights and shadows.

Atherosclerosis as an inflammatory process has been a Leitmotiv in cardiology for the past 30 years, and the hypothesis of a causal role has now been tested in several clinical trials aimed at demonst...

Blood Pressure Variability is Associated With Lower Cognitive Function: An Elderly Cohort Study in Hong Kong.

Cognitive impairment is a major geriatric health issue with significant public health burdens. Emerging evidence suggests blood pressure variability (BPV), particularly its dynamic fluctuations, may c...

Colchicine in coronary artery disease: limitations and challenges.

Colchicine has emerged as a promising anti-inflammatory option for secondary prevention in coronary artery disease, but its role in routine practice remains uncertain. Evidence from randomised trials ...

Unintended Financial Barriers: When "Generic" Does Not Mean Affordable.

Sacubitril/valsartan is a foundational component of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), demonstrating reductions in cardiovascular morta...

Comprehensive Evaluation of YJ-2 as a PAD4 Inhibitor in Alleviating Ischemic Brain Injury: From NETs-Induced Neurotoxicity to In Vivo Neuroprotection.

AIMS: To evaluate the neuroprotective potential of YJ-2, a novel peptidylarginine deiminase 4 (PAD4) inhibitor, against ischemia/reperfusion brain injury by targeting neutrophil extracellular trap (NE...