Pharmacokinetic Characteristics of 6-Hydroxykaempferol-3,6-Diglucoside in Normal and Diabetic Cardiomyopathy Mice.
6-Hydroxykaempferol-3,6-diglucoside is an important flavonoid constituent of Carthamus tinctorius L., with potential antioxidant and myocardial protective effects. However, its pharmacokinetic charact...
Crataegus oxyacantha Extract Enhances Cardiac Adaptation and Reduces Oxidative-Inflammatory Stress in Broiler Chickens Raised at High Altitude Under Cold Stress.
BACKGROUND: Cold stress and high-altitude hypoxia cause pulmonary hypertension syndrome (PHS) in broilers via cardiac overload, oxidative-inflammatory stress, and ET-1/NO imbalance. OBJECTIVES: This s...
Echocardiographic Findings in Small-Breed Dogs With Myxomatous Mitral Valve Disease and the Severity of Mitral Regurgitation, Heart Size and Clinical Signs Myxomatous Mitral Valve Disease in Dogs.
BACKGROUND: The main goal of this study was to identify various brightness, motion and Doppler echocardiographic variables in small-breed dogs with myxomatous mitral valve disease. ANIMALS: Sixty clie...
Pinoresinol diglucoside from Eucommia ulmoides attenuates diabetic cardiomyopathy through suppressing the store-operated calcium entry and downregulating the STIM1/Orai1/NFAT3 signaling pathway.
Pinoresinol diglucoside (PDG), an active component derived from Eucommia ulmoides, exhibits therapeutic effects against apoptosis, inflammation, and hypertrophy, etc. However, whether PDG plays a prot...
Targeting vascular smooth muscle cells with natural compounds to combat atherosclerosis.
Atherosclerosis (AS) is widely recognized as the principal pathological substrate underlying chronic cardiovascular diseases (CVDs). It is a chronic, progressive, and inflammatory disease characterize...
Battle of the wall for aromatic "orifice-opening" agents: defending and breaching the blood-brain barrier.
The brain is the most stringently safeguarded organ in the human body. The 7-mm-thick cranial vault shields the central nervous system (CNS) from external damage, while the blood-brain barrier (BBB) f...
Lower Risk of Type 2 Diabetes Mellitus With PCSK9 Inhibitors Compared With Other Lipid-Lowering Agents Among Patients With Hyperlipidaemia.
AIMS: The purpose of this paper is to compare the risk of incident type 2 diabetes mellitus (T2DM) among patients with hyperlipidaemia treated with proprotein convertase subtilisin/kexin type 9 (PCSK9...
Neurogenic shock to the heart: a rare case of meningitis-triggered reverse takotsubo cardiomyopathy.
Reverse takotsubo cardiomyopathy, a rare variant of stress-induced cardiomyopathy, is characterized by basal hypokinesis with apical sparing and can be associated with neurological insults. Prompt rec...
Association of fish intake with systemic immune-inflammation index: Potential mediating role of n-3 polyunsaturated fatty acids.
OBJECTIVE: Low inflammation associated with fish intake may reflect not only the amount of fish consumed but also its nutrient composition and related lifestyle factors. This study investigated the re...
Atrial Tachycardia Utilizing Bachmann's Bundle as an Epicardial Bypass: A Case Suggestive of a Dual-Loop Mechanism.
A 70-year-old man with a history of prior ablation for atrial fibrillation presented with atrial tachycardia (AT). Electrophysiological studies revealed roof-dependent and localized-reentrant ATs. Dur...
Thermoneutrality Reveals True Cardiac Adaptations to Exercise, Disease, and Aging in Male Mice.
AIM: Standard laboratory housing (21°C) imposes chronic cold stress on mice, yet its fundamental impact on cardiac plasticity remains poorly defined. We systematically interrogated how environmental t...
Glucagon-like peptide-1 receptor agonists versus sodium-glucose cotransporter-2 inhibitors in adults with type 2 diabetes and atrial fibrillation: a multicenter comparative effectiveness cohort study of cardiovascular and arrhythmic outcomes.
AIMS: To compare glucagon-like peptide-1 receptor agonists (GLP-1RA) with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) for cardiovascular, atrial fibrillation (AF) disease course, and safety ou...
Efficacy and safety of exercise for hypertrophic cardiomyopathy: a systematic review and meta-analysis.
BACKGROUND: Patients with hypertrophic cardiomyopathy (HCM) are generally restricted from exercising. We aimed to investigate the effects of exercise on cardiorespiratory fitness, cardiac structure, c...
Facilitators and barriers to home eating behaviors in patients with heart failure: A qualitative descriptive study comparing patient and healthcare expert perspectives.
AIM: To identify facilitators and barriers to home eating behaviors related to dietary management in patients with heart failure (HF) by comparing patient narratives and healthcare expert (HCE) perspe...
The Distally Based Saphenous Neurocutaneous Perforator Flap: A Versatile Donor Site for Reconstruction of Complex Soft Tissue Defects of the Lower Leg.
BACKGROUND: Repair of both simple and complex defects in the distal lower leg continues to be a challenging task for reconstructive surgeons because of the local paucity of soft tissue available for t...
Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.
T lymphocytes are increasingly recognized as central regulators of cardiac inflammation, contributing to both tissue repair and disease progression across conditions such as myocardial infarction, hea...
Role of Personalized Medicine in Myocardial Infarction With Nonobstructive Coronary Artery Disease (MINOCA): An Updated Review.
Cardiovascular diseases, notably myocardial infarction (MI), contribute significantly to global mortality. While traditional MIs are often associated with notable coronary artery blockages, a subgroup...
Longer Baseline Left Ventricular Activation Time Is Associated With Lower Mortality and Lower Risk of Heart Failure Hospitalization in Cardiac Resynchronization Therapy Recipients.
INTRODUCTION: Many patients do not benefit from cardiac resynchronization therapy (CRT) with current guideline parameters. The objective of this study was to examine the relationship between left vent...
Transcatheter pulmonary valve replacement: what we know, what we still want to know.
PURPOSE OF REVIEW: Transcatheter pulmonary valve replacement (TPVR) has transformed the management of patients with congenital heart disease (CHD) with dysfunctional pulmonary outflow tracts. Technolo...
Preventive Antiarrhythmic Properties of Melatonin in Experimental Diabetic Cardiomyopathy in Rats.
Diabetes mellitus (DM) promotes cardiac arrhythmias, whereas melatonin confers antiarrhythmic effects. Cellular targets modified by DM and melatonin largely overlap, which warrants testing melatonin a...