Impact of Inhalation Sedation on Cardiovascular Haemodynamics in Hypertensive Patients Requiring Dental Treatment: A Clinical Observational Study.
BACKGROUND: Several research studies reported the anxiolytic and analgesic properties of nitrous oxide sedation, as well as its effectiveness in facilitating dental procedures for anxious populations,...
Lipid Metabolic Disorders: a Pivotal Driver in Type 2 Diabetes Mellitus Pathogenesis.
PURPOSE OF REVIEW: This review aims to synthesize recent evidence to clarify the causal and mechanistic roles of lipid metabolism disorders as core drivers of type 2 diabetes mellitus (T2DM), and to s...
Harnessing Regulatory T Cells to Modulate Acute Brain Injury: From Mechanisms to Therapy.
Neuroinflammation is a defining feature of acute brain injury such as acute ischemic stroke, traumatic brain injury, intracerebral hemorrhage, and subarachnoid hemorrhage, driven by complex immune int...
Early implementation of transradial mechanical thrombectomy in a primary stroke center: a sequential cohort propensity score-matched study.
BACKGROUND: This study assessed the early implementation of transradial access (TRA) for mechanical thrombectomy (MT) in a primary stroke center (PSC) using a retrospective sequential cohort design wi...
Serum Copper-to-Zinc Ratio and Oxidative Stress Are Associated with Anemia in Older Adults with Cardiovascular-Kidney-Metabolic Syndrome.
Chronic oxidative stress is a molecular hallmark of cardiovascular-kidney-metabolic (CKM) syndrome, yet its contribution to CKM-associated anemia beyond erythropoietin deficiency and iron restriction ...
Left Atrial Structural and Functional Changes After Pulmonary Vein Isolation Using Different Energy Sources.
Background: Pulmonary vein isolation (PVI) is an established treatment for atrial fibrillation (AF); however, its impact on long-term left atrial (LA) structural and mechanical remodeling may differ b...
Updates in the Diagnosis and Management of Hypertension: A Review of Recent Guidelines.
Hypertension is one of the leading contributors to global cardiovascular morbidity and mortality. Recent updates to major international guidelines have introduced changes in diagnostic thresholds, ris...
Beyond vasodilation: sotatercept and the remodeling hypothesis in hfpef-associated pulmonary hypertension.
Pulmonary hypertension complicating heart failure with preserved ejection fraction (HFpEF), particularly the combined post- and pre-capillary form (CpcPH), has lacked any mechanism-specific therapy, a...
The Prognostic Impact of the Cachexia Index in Patients Hospitalized with Heart Failure.
Background and Objectives: Cachexia is a systemic wasting syndrome associated with poor outcomes in chronic diseases, including heart failure (HF). Although the cachexia index (CXI), which integrates ...
Serum Pharmacochemistry-Guided DARTS-MS Profiling Reveals Potential Mechanisms of Caragana jubata Against Hypoxic Pulmonary Hypertension.
Hypoxic pulmonary hypertension (HPH) is a progressive vascular disease characterized by an abnormal increase in pulmonary arterial pressure resulting from pulmonary vasoconstriction and pulmonary vasc...
Modeling Neuroimmunological Interactions at the Blood-Brain Barrier Using In Vitro 3D Human Organoids: Inflammation and Ischemia-Reperfusion Injury.
Numerous central nervous system pathological conditions involve blood-brain barrier (BBB) disruption and the egress of immune cells in the brain. Controlling immune cell transmigration into the brain ...
Responsiveness to adenosine diphosphate on carotid arterial and platelet functions in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats.
Extracellular nucleotides, including adenosine diphosphate (ADP), are pivotal in regulating vascular and platelet function. Thus, their abnormal function contributes significantly to the initiation an...
Antithrombotic Management in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation.
PURPOSE OF REVIEW: Atrial fibrillation (AF) and/or the need for oral anticoagulation (OAC) frequently coexist with stable chronic coronary syndrome (CCS). In this population, clinicians must carefully...
Natural extracts for the treatment of atherosclerosis.
Atherosclerosis (AS) is a cardiovascular disease with high mortality and disability rates, and the increasing number of cases urgently demands more effective therapeutic options. AS is characterized b...
Transcriptome Reprogramming in Heart Failure: The Hidden Splicing Code.
PURPOSE OF REVIEW: Heart failure remains a major cause of morbidity and mortality that is associated with myocardial changes in metabolism, contractile function, and molecular remodeling. Cardiomyopat...
Hepatic artery aneurysm rupture into the biliary tract during long-term left ventricular assist device support successfully treated by transcatheter arterial embolization: a case report.
Bleeding complications remain a major concern in patients supported by long-term left ventricular assist devices (LVADs). Although gastrointestinal bleeding is common, hemobilia due to rupture of a he...
Neurotherapeutic roles of the protective arm of the renin-angiotensin system: from inflammation to cognitive rescue.
The renin-angiotensin system (RAS), traditionally recognized for its role in regulating blood pressure and fluid homeostasis, is increasingly understood to exert important effects across multiple orga...
Parameter estimation in blood flow models from highly undersampled k-space magnetic resonance imaging data.
4D Flow Magnetic Resonance Imaging (MRI) is the state-of-the-art technique for measuring blood flow and provides valuable data for inverse problems in the cardiovascular system. However, acquiring 4D ...
Secoisolariciresinol diglucoside ameliorates muscarinic acetylcholine receptor mediated activation of NLRP3 inflammasome in cardiomyocytes.
BACKGROUND: Secoisolariciresinol diglucoside (SDG), the main lignan found in flaxseed, contributes to cardioprotection. However, its molecular mechanism of action remains unknown. NOD-like receptor pr...
Endovascular treatment of tumor-related dural sinus stenosis, venous outflow obstruction, and secondary intracranial hypertension: a systematic review of the literature.
INTRODUCTION: Tumors involving dural venous sinuses can lead to venous outflow obstruction and secondary intracranial hypertension. While surgical resection can decompress the sinus, such procedures c...