Intersection of Pediatric Hypertension and Cardiovascular-Kidney-Metabolic Disease.
PURPOSE OF REVIEW: The purpose of this review is to describe the intersection between pediatric hypertension and advancing stages of cardiovascular, kidney metabolic syndrome in children and adolescen...
Contemporary Outcomes of the Ross Procedure in Adults: Implications for Current Clinical Practice.
BACKGROUND: With renewed enthusiasm for the Ross procedure in adults in recent years, long-term data using contemporary techniques are needed. OBJECTIVES: The purpose of this study was to evaluate lon...
Assessing the impact of combined nutritional and physical activity interventions for patients with atrial fibrillation who are overweight: a systematic review protocol.
INTRODUCTION: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with reduced quality of life and increased healthcare utilisation. AF is increasingly recognise...
Chronic mesenteric ischaemia: an overlooked cause of unintentional weight loss.
Chronic mesenteric ischaemia (CMI) is a rare but potentially life-threatening condition, often underdiagnosed due to its vague and non-specific symptoms. We describe a patient who presented with progr...
Implementation and Evaluation of a Social Networking Service-Based Mobile Patient-Generated Health Data System With Direct Electronic Medical Record Integration: Prospective Observational Study.
BACKGROUND: Patient-generated health data (PGHD) can enhance patient-centered care by improving disease awareness and preparedness for clinical encounters. However, automated incorporation of PGHD int...
Postoperative arrhythmias and long-term cardiac function in pediatric congenital heart disease after cardiopulmonary bypass: a single-center retrospective cohort study.
Postoperative arrhythmias are common in pediatric patients undergoing cardiopulmonary bypass (CPB); however, their impact on long-term cardiac function remains unclear. To investigate the association ...
Renal vein thrombosis as a reversible vascular renal complication of CLOVES syndrome: a case report.
PIK3CA-related overgrowth spectrum (PROS) comprises mosaic gain-of-function variants in PIK3CA that lead to segmental overgrowth and complex vascular malformations. Renal involvement has been inconsis...
Auriculotemporal nerve morphology revisited: a novel classification based on root pattern and arterial topography.
The auriculotemporal nerve (ATN), carrying both sensory and parasympathetic fibers, is a branch of the mandibular nerve (MN) and courses through the anatomically complex infratemporal fossa (ITF). Alo...
Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4.
Aortic dissection (AD) is a life-threatening vascular emergency characterized by medial degeneration and vascular smooth muscle cell (VSMC) loss. Although disruption of zinc homeostasis has been repor...
Umbilical vein-ductus venosus angle: a novel ultrasound marker for predicting optimal umbilical venous catheter placement.
UNLABELLED: Umbilical venous catheterization is a common procedure performed in intensive care units. Point-of-care ultrasonography enables efficient vascular access and reliable assessment of cathete...
Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).
The heart of Phasmida (stick insects) remains poorly understood, particularly regarding its overall physiology and associated cells. Here, we integrate the morphology of the heart and associated cells...
Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment.
Deterioration of the blood-brain barrier (BBB), including impaired neurovascular uncoupling, contributes to cognitive decline in aging. The BBB is formed principally by brain microvascular endothelial...
Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension.
Schistosomiasis-associated pulmonary hypertension (Sch-PH) is the most common form of group I PH worldwide. Recently, data revealed that the preclinical Sch-PH animal model exhibited gut and lung micr...
Regulatory logic underlying neural crest contributions to the head versus the heart.
Neural crest cells exhibit axial-level-specific transcriptional programs, yet the regulatory mechanisms underlying their fate decisions remain unclear. Here, we investigate whether differential transc...
Coronary artery bypass grafting is a well-established, durable, and safe surgical intervention. However, coronary artery disease continues to progress after the procedure. Patients who have undergone ...
Randomized trials evaluating multiarterial grafting (MAG) vs single arterial grafting (SAG) during coronary artery bypass grafting (CABG) have not demonstrated a long-term survival benefit, whereas co...
Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) is an effective therapy for reducing low-density lipoprotein (LDL) cholesterol (LDL-C) in adults with hyperlipidemia, including hete...
Resources for observational comparative research have expanded enormously in recent years to include very large sources of granular, routinely collected health care data and modern statistical, epidem...
Metabolic remodeling, marked by maladaptive shifts in substrate use and energy production, is a hallmark of pathologic cardiac hypertrophy. Yet the mechanisms linking stress signaling to impaired myoc...
Lipoprotein(a) [Lp(a)] is a risk factor for coronary heart disease. Whether baseline Lp(a) identifies higher risk patients who derive more benefit from evolocumab is not established in a population wi...