There is ongoing debate regarding the optimal multimodal treatment for patients with resectable locally advanced esophageal adenocarcinoma, with the recent ESOPEC trial suggesting perioperative chemot...

To develop a novel wearables-based sleep index that can quantify sleep disruption after lung resection and to apply machine learning analysis to these indices to identify patients exhibiting distinct ...

Although transcatheter mitral valve-in-valve replacement (mViV) is safe, long-term outcomes compared with reoperative surgical mitral valve replacement (rSMVR) remains unknown. This study compared lon...

This study aimed to evaluate the impact of proximal versus distal aortic clamping during thoracoabdominal aortic aneurysm (TAAA) repair, focusing on the incidence and predictors of left recurrent lary...

The objective of this secondary analysis was to examine the impact of two perfusion modalities on S100B levels and neural injury outcomes in congenital heart surgery patients undergoing cardiopulmonar...

Surgical left atrial appendage occlusion (sLAAO) is known to prevent strokes in patients with atrial fibrillation (AF). However, for AF patients on long-term anticoagulation (AC) little is known regar...

Management of atrial fibrillation (AF) at the time of coronary artery bypass grafting (CABG) is a Class 1 recommendation. This study evaluated trends in AF management and their association with long-t...

Pulsed field ablation (PFA) is emerging as alternative to thermal ablation for pulmonary vein isolation (PVI) in atrial fibrillation, though PFA-specific complications have arisen. This review provide...

Nanosecond pulse field ablation (nanoPFA) is an emerging nonthermal modality that may reduce muscle contractions and enable atrial fibrillation (AF) ablation under conscious sedation.

Comorbidity Trajectories Before and After Hip Fracture in Elderly Patients: A Korean Nationwide Database Cohort Study.

BACKGROUND: Hip fractures in older adults often signal frailty and are associated with poor outcomes, including mortality and disability. Although a high burden of comorbidities is common, little is k...

Glucose-dependent insulinotropic polypeptide receptor agonism improves heart failure with antifibrosis through Akt-dependent nitric oxide signaling.

BACKGROUND: Cardiac fibrosis is a pathological remodeling process that contributes to the development and progression of heart failure. Although glucose-dependent insulinotropic polypeptide (GIP) may ...

Association between empagliflozin exposure and skeletal muscle degeneration in patients with heart failure.

BACKGROUND: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have become essential in the management of heart failure. Their prognostic benefits are consistent across older adults, frail, and under...

Early quantitative stress-perfusion cardiac magnetic resonance reveals perfusion abnormalities consistent with coronary microvascular dysfunction in MINOCA patients with otherwise normal cardiac magnetic resonance findings.

Coronary microvascular dysfunction (CMD) is a proposed contributor to myocardial infarction with non-obstructive coronary arteries (MINOCA), but the value of early quantitative stress-perfusion CMR (Q...

Stroke incidence trends and the role of chronic disease management in a universal health coverage system: a retrospective observational study in Macao, 2019-2024.

OBJECTIVE: To analyse the temporal trend of stroke incidence from 2019 to 2024 in Macao and evaluate its relationship with hypertension (HTN) and type 2 diabetes mellitus (T2DM) management within a un...

Disease-Related Etiologies of Nocturia: A Focused Literature Review.

PURPOSE OF REVIEW: Nocturia is a highly prevalent symptom that affects multiple aspects of health. However, it is often underrecognized and undertreated, leading to problems both within the genitourin...

Periodic limb movements of sleep and hypertension in patients with obstructive sleep apnea: a hypothesis-generating analysis from a polysomnographic cohort.

BACKGROUND: Hypertension in obstructive sleep apnea (OSA) is incompletely explained by intermittent hypoxia and respiratory events alone. Periodic limb movements of sleep (PLMS) induce repetitive noct...

Trials and tribulations of spironolactone in heart failure with preserved ejection fraction: Insights from the SPIRIT-HF trial.

Heart failure with preserved ejection fraction represents a clinical challenge, accounting for at least 50% of heart failure (HF) cases globally, with a historical lack of efficacious and disease-modi...