Early urinary sodium vs B-type natriuretic peptide for predicting 30-day outcomes in acute decompensated heart failure: a prospective cohort study.

AIM: To compare the prognostic performance of early urinary sodium (UNa) and B-type natriuretic peptide (BNP) for predicting 30-day adverse outcomes in emergency department (ED) patients with acute de...

The social context and environment as targets for heart failure prevention.

The prevalence of heart failure (HF) continues to rise and disproportionately affects disadvantaged populations. This has created an urgent need to concurrently tackle HF prevention and therapeutics, ...

Cognitive assessment in heart failure: clinical value, timing, and practical tools.

This narrative review examines the clinical value of cognitive assessment in heart failure, highlighting optimal timing, practical tools, and the epidemiology, pathophysiology, and clinical implicatio...

Intravenous Exposure to Amino-polystyrene Induces Excessive Autophagy and Apoptosis in Myocardium Through ROS Driven PI3K/AKT/mTOR Axis.

Polystyrene (PS) is a pervasive plastic whose threat to human health is growing, yet its cardiotoxicity, particularly under clinically relevant exposure scenarios, remains poorly understood. This stud...

The Woodpecker variable-speed drilling protocol for robot-assisted subaxial cervical pedicle screw placement: technique and a consecutive series of 1027 screws.

Published descriptions of robot-assisted cervical pedicle screw placement remain limited, particularly for subaxial screws and for workflows integrating positioning, registration, and drilling. Small ...

The diagnostic accuracy of left ventricular ejection fraction assessment between visual and artificial intelligence-based algorithms on bedside ultrasound.

BACKGROUND: Focused cardiac ultrasound (FoCUS) has become the standard of care for bedside assessments of cardiac function. With the integration of artificial intelligence (AI), there is limited evide...

Unveiling the Immune Mechanisms of Hypertension With Single-Cell Transcriptome-Wide Mendelian Randomization.

Immune dysregulation is closely implicated in hypertension pathogenesis, yet specific therapeutic targets are lacking. We integrated expression quantitative trait loci (eQTLs) for genes expressed in 1...

Polygonum cuspidatum Exosome-Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK-Mediated PASMC Phenotypic Switching.

Hypoxic pulmonary hypertension (HPH) is characterized by excessive proliferation of pulmonary vascular cells, ultimately resulting in right heart failure and death. Although resveratrol, an active com...

Calcium-mediated force-interval relationship drives post-extrasystolic potentiation in premature ventricular complexes: a computational study.

Premature ventricular complexes (PVCs) are common cardiac arrhythmias that can lead to cardiomyopathy when frequent. Post-extrasystolic potentiation (PESP), which is the transient increase in contract...

Subcentimeter Ileal Neuroendocrine Tumor Resection for Obscure Gastrointestinal Bleeding Followed by Pacemaker-Treated Sick Sinus Syndrome: A Case Report.

BACKGROUND Obscure gastrointestinal bleeding (OGIB) denotes recurrent hemorrhage after nondiagnostic bidirectional endoscopy. In overt presentations with suspected small-bowel origin, capsule endoscop...

Right atrial thrombus and pulmonary embolism one year after ventricular septal defect patch repair: successful surgical management of a complicated case.

BACKGROUND: Right heart thrombi are rare but life-threatening, with particularly high mortality when accompanied by pulmonary embolism (PE). Cardiac surgery may predispose to in-situ thrombus formatio...

Promoting Effect of (+)-Borneol on Alzheimer's Disease Treatment in APP Transgenic Zebrafish and Its Blood-Brain Barrier Permeation Mechanism.

( +)-Borneol (Bor) has been shown to enhance drug penetration across the blood-brain barrier (BBB); yet its mechanisms of action and adjuvant effects on Alzheimer's disease (AD) drugs remain insuffici...

Cottonseed Oil Attenuates Traumatic Brain Injury by Inhibiting AKT/GSK-3β-mediated Neuroinflammatory Responses.

Traumatic brain injury (TBI) is a major cause of long-term neurological disability worldwide, and effective therapeutic strategies remain limited. Cottonseed oil (CSO), a plant-derived oil rich in pol...

Neuro-immune crosstalk in lung cancer brain metastasis: mechanisms, therapeutic targets, and translational opportunities.

Brain metastasis remains one of the most devastating complications of lung cancer, contributing to poor prognosis and limited therapeutic efficacy. Increasing evidence suggests that the development an...

Advances in ferroptosis and cuproptosis: implications for spinal cord injury.

Spinal cord injury (SCI) is characterized by multifaceted pathophysiological cascade encompassing neuron necrosis, inflammatory responses, glial scar deposition, and impediments to axon regeneration. ...

Predictive value of early postoperative hemodynamic parameters of Rex shunt graft for graft thrombosis in children with cavernous transformation of the portal vein.

OBJECTIVE: To investigate the predictive value of early hemodynamic parameters within Rex graft for postoperative graft thrombosis in children with cavernous transformation of the portal vein (CTPV). ...

Viscosity matters: OCTA assessment of retinal microcirculation under silicone oil tamponade.

PURPOSE: This retrospective observational cohort study utilized in situ optical coherence tomography angiography (OCTA) to directly compare the early retinal and choroidal microvascular effects of 100...

Coronary-Subclavian Steal Syndrome in a Post-Coronary Artery Bypass Grafting Patient: A Reversible Cause of Myocardial Ischemia.

BACKGROUND Coronary-subclavian steal syndrome (CSSS) is a rare but clinically significant cause of myocardial ischemia in patients with prior coronary artery bypass grafting (CABG), particularly when ...

Glymphatic dysfunction in cerebellar neurodegeneration: mechanistic insights and emerging clinical implications.

BACKGROUND AND PURPOSE: The glymphatic system is a glial-dependent perivascular clearance pathway that maintains central nervous system homeostasis through cerebrospinal fluid and interstitial fluid e...

Genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis: A bidirectional Mendelian randomization study with exploratory lipidomic analyses.

Myocarditis is an inflammatory myocardial disease with potentially severe outcomes. Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) regulate immune tolerance, but the asso...