Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis.

INTRODUCTION: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is closely associated with coronary heart disease (CHD) and adverse cardiovascular outcomes, but the comparative value of the triglyceri...

[Structural and functional cardiac parameters in older adults residing in a long-term social care facility.].

The aging of the population is accompanied by an increase in the prevalence of chronic heart failure, including those with preserved ejection fraction, which necessitates the early detection of struct...

The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study.

BACKGROUND: Eicosanoids are bioactive signaling lipids that have roles in airway remodeling, smooth muscle hypertrophy, emphysema and pulmonary fibrosis via mediation of pro- and anti-inflammatory pat...

Influence of symptom burden on physical activity among patients with atrial fibrillation: The chain-mediating roles of exercise sensitivity and kinesiophobia.

OBJECTIVE: Grounded in an integrated fear-avoidance and cognitive-behavioural framework, this study aimed to examine the independent and sequential mediating roles of exercise sensitivity and kinesiop...

Validation of deep learning enabled software MetronMind to measure vertebral heart size and vertebral left atrial size in dogs.

BACKGROUND: Vertebral heart size (VHS) and vertebral left atrial size (VLAS) are objective radiographic measurements of heart and left atrial size, respectively and are associated with inter- and intr...

Varicella-zoster virus infection of the central nervous system: clinical features and proteomic analysis of cerebrospinal fluid.

OBJECTIVE: Varicella-zoster virus (VZV) involvement of the central nervous system (CNS) can cause severe complications; however, the underlying pathogenic mechanisms remain incompletely understood. Th...

Case Report: Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome with flow cytometric phenotyping before and after treatment in a patient with urothelial carcinoma.

Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS) is an uncommon immune-related adverse event (irAE) associated with the use of immune checkp...

Intensive blood pressure control in type 2 diabetes: a meta-analysis of randomized controlled trials.

BACKGROUND: Although guidelines recommend lower blood pressure targets for patients with type 2 diabetes (T2D), evidence from randomized controlled trials (RCTs) remains inconsistent regarding the bal...

The triglyceride-glucose-waist-to-height ratio is the strongest predictor of reduced kidney function in elderly hypertensive patients.

BACKGROUND: The triglyceride-glucose index (TyG) and its derivatives, such as the TyG-waist-to-height ratio (TyG-WHtR), provide reliable surrogate measures for estimating insulin resistance (IR). Thei...

Effects of Positive Event Recording on Rehabilitation Outcomes in Elderly Patients with Coronary Heart Disease and Anxiety.

BACKGROUND: Elderly patients with coronary heart disease (CHD) are prone to psychological disorders during treatment. Strengthening psychological well-being can improve rehabilitation outcomes. This s...

Effects of cardiac rehabilitation on atrial fibrillation recurrence, mortality, hospitalization, and exercise capacity: a systematic review and meta-analysis.

BACKGROUND: Cardiac rehabilitation (CR) may benefit patients with atrial fibrillation (AF) in areas such as exercise capacity. However, evidence regarding its impact on AF recurrence, a key clinical o...

Meningeal immunity and "Interstitial" therapy: a new paradigm for immunotherapy in glioblastoma.

Glioblastoma (GBM) is one of the most aggressive brain tumors, and its immunotherapy faces significant challenges, including the physical barrier of the blood-brain barrier, the tumor immunosuppressiv...

Case Report: Metastatic right ventricular tumor and pulmonary embolism from cervical cancer post COVID-19 infection.

The intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix combined with pulmonary embolism is extremely rare, with mean survival less than six months. We report a case of...

Glycocalyx disruption mediates HP-PRRSV-induced microvascular endothelial dysfunction and underlies astragalus polysaccharide's antiviral efficacy.

BACKGROUND: Pulmonary microvascular endothelial cells (MVECs) are not only targets of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) but also the pivotal hub of i...

Feasibility and findings of different radiographic methods in diagnosing canine heartworm disease.

BACKGROUND: Heartworm disease (HWD) represents the pathological consequences of heartworm (HW) (Dirofilaria immitis) infection on different organs and organ systems, primarily the lungs and heart. Rad...

Transplantation of human umbilical mesenchymal stromal cells attenuates heart failure progression in a rat model.

Myocardial infarction (MI), mainly caused by coronary artery occlusion, remains a leading cause of death worldwide. Although many patients survive after emergency treatment, chronic MI often develops,...

Dexamethasone restores blood-brain barrier integrity in an in vitro heatstroke model.

Heat-related diseases and their treatments are becoming the center of focus due to global warming resulting in rising global temperatures. Heatstroke is the most hazardous condition of heat-related di...

Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways.

Immune checkpoint inhibitor (ICI)-related myocarditis is a rare but often fatal adverse event that has gained increasing attention due to the widespread clinical use of ICIs. This review explores the ...

Assessment of Renal Changes in Bardet-Biedl Syndrome with Particular Emphasis on Kidney Size, Function, and Blood Pressure Control.

INTRODUCTION: Bardet-Biedl syndrome (BBS) is a genetically heterogeneous ciliopathy characterized by obesity, retinal dystrophy, cognitive impairment, hypogonadism, and congenital renal anomalies, whi...

Integrated Mindfulness and Cardiopulmonary Rehabilitation Improves Cardiopulmonary Performance and Psychological Stress in Pulmonary Arterial Hypertension.

OBJECTIVE: To investigate the effects of mindfulness-based stress reduction (MBSR) combined with cardiopulmonary rehabilitation (CR) training on cardiopulmonary function, oxygen delivery efficiency, a...