2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TO...
Case Report: Two cases of PD-1 inhibitor-associated myocarditis with bidirectional ventricular tachycardia.
BACKGROUND: The clinical application of targeted anti-programmed cell death protein 1 (PD-1) therapy has significantly improved the prognosis of patients with various advanced malignancies. However, l...
Contribution to the pathogenesis and early diagnosis of glaucoma. A Review.
The aim of the work is to summarize recent observations on the pathogenesis of glaucoma, both from animal experiments and from clinical examinations of humans suffering from pathological intraocular p...
Myocarditis After mRNA Vaccination: A Metabolic-Innate Immune Cascade Centered on Lipid Nanoparticles.
mRNA vaccine-associated myocarditis is a rare but clinically important adverse event whose pathogenesis remains incompletely understood. Initial hypotheses focused primarily on the spike protein antig...
The Association of Race and Ethnicity with Six-Minute Walk Distance: The Multi-Ethnic Study of Atherosclerosis.
BACKGROUND: The limited data on functional capacity among older Americans suggest lower 6-min walk distance (6MWD) among African American than among White persons. We aimed to investigate the associat...
Serum uric acid levels and cardiorenal complication prevalence in hypertensive patients before and after the COVID-19 pandemic: a retrospective cross-sectional study from a tertiary traditional Chinese medicine hospital.
BACKGROUND: Hyperuricemia is a recognised risk factor for cardiorenal complications in hypertensive patients. While prior studies have documented pandemic-related metabolic changes including shifts in...
Defective efferocytosis links autonomic dysfunction and atrial fibrillation: multi-omics integration and in vivo validation.
INTRODUCTION: Atrial fibrillation (AF) is the most common and clinically significant arrhythmia requiring treatment. Although an imbalance between the sympathetic and vagal branches of autonomic nervo...
Sex- and Age-specific Divergent Trends in Walking, Obesity, and Hypertriglyceridemia in Middle-Aged Adults: A Joinpoint Regression Analysis, 2005-2023.
Introduction: Managing obesity and lipid levels is essential for the prevention of chronic diseases. Despite clinical guidelines emphasizing lifestyle interventions, the long-term sex- and age-specifi...
Invisible threats of microplastics induced toxicity: Oxidative and inflammatory pathways in the CNS and retina.
The global spread of microplastics has become a serious public health concern. Once thought to be inert, microplastics are now recognized as biologically active agents capable of accumulating in the b...
Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome.
Trisomy 21 (T21) results in Down syndrome (DS), a condition associated with a high prevalence of pulmonary complications. Pulmonary hypertension (PH) is a significant comorbidity in individuals with T...
The association between single-point insulin sensitivity estimator and high-sensitivity C-reactive protein with collateral circulation in coronary chronic total occlusion.
BACKGROUND: The single-point insulin sensitivity estimator (SPISE) is a novel metric used to assess insulin resistance. However, its association with collateral circulation impairment in patients with...
Pilot analysis of protein profile alterations in plasma and aortic tissue of spontaneously hypertensive rats.
The role of proteins in cellular activity has received close attention. Proteome analysis can detect early enough changes in the cell before the appearance of pathological changes. Due to the increasi...
The interplay between neuroinflammation and endothelial dysfunction in cerebral small vessel disease.
Cerebral small vessel disease (CSVD) is a leading cause of ischemic stroke and vascular cognitive impairment. Despite well-defined neuroimaging features and a substantial clinical burden, the underlyi...
Physiological strategies for brain delivery.
The blood-brain barrier (BBB) remains an obstacle to treat neurological diseases, prompting the development of delivery strategies to target therapies to the brain. Receptor-mediated transport has bec...
Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis.
BACKGROUND: Diabetic cardiomyopathy (DCM) is a diabetes-related myocardial disorder causing fibrosis, hypertrophy, and progressive diastolic and systolic dysfunction. This study aims to explore how me...
[Clinical features of chronic pain and premorbid factors in patients with various phenotypes of metabolic syndrome].
OBJECTIVE: To identify the clinical features associated with chronic pain and the premorbid factors in patients with metabolic syndrome of various phenotypes. MATERIALS AND METHODS: In this prospectiv...
Real-World Antithrombotic Management of Nonvalvular Atrial Fibrillation in Patients Undergoing Percutaneous Coronary Intervention in China: A Cross-Sectional Study.
Antithrombotic therapy in patients with nonvalvular atrial fibrillation (NVAF) undergoing percutaneous coronary intervention (PCI) is clinically challenging, with real-world strategies often remaining...
Association of Brachial-Ankle pulse pressure with coronary artery stenosis severity: A sex-specific cross-sectional study in Chinese adults.
OBJECTIVES: To investigate the association between brachial and ankle pulse pressure and the severity of coronary artery stenosis, as well as to explore sex-specific differences in these associations....
Hypertension management profiles in Chinese adults aged 60 years and older.
BACKGROUND: Hypertension control in older adults depends on sustained self-management, yet education strategies often overlook heterogeneity in barriers and capacities. OBJECTIVE: To examine hypertens...
Efferocytosis in heart failure: Mechanisms, dysregulation and therapeutic potential.
Heart failure (HF) remains one of the leading health problems globally. It is often characterized by unresolved inflammation, adverse cardiac remodeling, and tissue damage. Efferocytosis, the process ...