Comparison of Labetalol With Versus Without Magnesium Sulfate on Intraoperative Blood Pressure Variability During Cesarean Delivery in Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study.

AIM: This study aims to investigate the effects of two medication regimens-labetalol combined with magnesium sulfate versus labetalol alone-on intraoperative blood pressure variability (BPV) and mater...

Comparison of Staged and Concomitant Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Cohort Study.

AIM: This study aims to compare the clinical outcomes of concomitant versus staged percutaneous coronary intervention (PCI) in patients with severe aortic valve disease and significant coronary artery...

The SMART-Youth study: protocol for a longitudinal prospective cohort study to identify disease-associated and lifestyle-associated cardiovascular risk factors for preclinical atherosclerosis in children with a chronic condition.

INTRODUCTION: Cardiovascular risk assessment and management in the paediatric population is a relatively uncharted territory. However, atherogenesis starts during childhood, making childhood and adole...

Novel Lipoprotein (a) Therapies: A Comprehensive Review.

PURPOSE OF REVIEW: Lipoprotein(a) [Lp(a)] is a genetically determined, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Plasma Lp(a) levels are 70...

Assessing quality gaps in hypertensive disorders of pregnancy care in China: an unannounced standardised patient study protocol.

BACKGROUND: Improving the quality of outpatient obstetric care is essential for achieving better maternal and perinatal outcomes, especially in resource-constrained settings. Despite guideline recomme...

Diagnostic accuracy of electronic medical record retrieval methods and a large language model for identifying cardiovascular events: a multisite retrospective validation study in a medical system in the United States.

OBJECTIVE: To compare the diagnostic accuracy of four available automated electronic medical record (EMR) retrieval methods, including a large language model (LLM)-assisted workflow, against manual ch...

Digital Health Technology for Improving Physical Function in Adults With Chronic Heart Failure: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BACKGROUND: Chronic heart failure (CHF) significantly impairs physical function and quality of life. Although exercise-based cardiac rehabilitation represents a primary therapeutic strategy, participa...

Association Between Gut Microbiota Dysbiosis and Bilirubin Metabolism Dysregulation in Children with Heart Failure.

Patients with heart failure (HF) demonstrate dysregulation in bilirubin metabolism. The specific characteristics of intestinal bilirubin metabolism in HF remain unclear. This study involved metagenomi...

Deactivation of Cardiac Devices at the End of Life: Clinical and Ethical Challenges.

PURPOSE OF REVIEW: Device deactivation in patients with heart failure is an increasingly relevant clinical and ethical challenge as the use of cardiovascular implantable electronic devices expands. RE...

Finerenone in Heart Failure with Preserved Ejection Fraction: Expanding the Role of Non-steroidal Mineralocorticoid Receptor Antagonists.

PURPOSE OF REVIEW: To evaluate the role of finerenone, a nonsteroidal mineralocorticoid receptor antagonist (MRA), in heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). R...

Coarctation-like features from skeletal anomalies: recognising extrinsic compression in fetal echocardiography.

Prenatal diagnosis of coarctation of the aorta (CoA) remains a challenging diagnosis in fetal cardiology. In rare situations, extrinsic compression of the aorta can produce a pseudocoarctation-like ap...

A cross-organ single-cell analysis of hypertension.

Hypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II-treated mi...

Design and Preclinical Evaluation of 18F-Labeled Phenoxyalkylguanidines as Novel Norepinephrine Transporter Radiotracers for Myocardial and Tumor Imaging.

The norepinephrine transporter (NET) is a key target for PET imaging of sympathetic nerves and neuroendocrine tumors. Herein, we developed a series of novel aryl 18F-labeled phenoxyalkylguanidine PET ...

Dynamic Evaluation of Vascular Remodeling and Aneurysm Progression Using Blood-Pool Contrast-Enhanced In Vivo Micro-CT in a Rodent Model.

Vascular graft remodeling and aneurysm progression are commonly studied in small animal models, but non-terminal methods for their assessment remain limited. This study evaluated contrast-enhanced mic...

A high-sensitivity TIE2-GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations.

TIE2 is an endothelial receptor tyrosine kinase (RTK) essential for vascular integrity, and constitutively active TIE2 mutants are involved in venous malformations (VMs). VMs are currently treated by ...

Exercise and Cardiovascular Risk Modulation in Post-COVID Syndrome.

PURPOSE OF REVIEW: Post-COVID syndrome (PASC) has emerged as a multisystem condition associated with persistent cardiovascular abnormalities, including endothelial dysfunction, arterial stiffness, chr...

Integrative multi-omics analysis of metabolite-protein interaction networks across different stages of coronary heart disease.

To elucidate the molecular characteristics of synergistic interactions across the clinical stages of coronary heart disease (CHD)-specifically stable angina pectoris (SAP), unstable angina pectoris (U...

INO80E Suppresses Oxidized LDL-Induced Endothelial Apoptosis Through HDAC1-Mediated Stabilization of YY1.

OBJECTIVES: Endothelial apoptosis is a central event in atherosclerotic vascular injury, yet the contribution of the INO80 chromatin-remodeling subunit INO80E to this process remains unclear. This stu...

Shock Induced Endotheliopathy and High Trauma Mortality-Fight-or-Flight Response Revisited.

Trauma with hemorrhagic shock causes about 2.3 million deaths yearly worldwide. Improved hemostatic management has shifted the relative distribution of mortality, leaving multiorgan failure (MOF) as a...

Cardiomyocyte-Specific bcl11b Knockout Causes Left Ventricular Noncompaction by Dysregulating pou3f2 and Titin.

Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by excessive trabeculation and deep intertrabecular recesses, yet its molecular mechanisms remain poorly understood. Here, we id...