TRF2 Recovers Ischemic Postconditioning Cardioprotection in Aged Myocardiocytes by Regulating CSNK2A2 Localization and FUNDC1 Dephosphorylation.

Ischemic postconditioning (I/Post), which is an effective intervention by activating endogenous cardioprotective pathways, recovers ischemia/reperfusion injury. However, this intervention is not as ef...

Associations of Reproductive Factors With Hypertension Prevalence and Blood Pressure Levels in Female Nurses: A Cross-Sectional Study.

Female nurses face unique health challenges due to pregnancy and physiological factors, yet the association between reproductive factors and blood pressure remains debated. This cross-sectional study ...

Rising Comorbid Alzheimer's and Hypertension Mortality in Older Adults in the United States: Trends and Disparities From a 21-Year CDC WONDER Analysis (1999-2019).

Hypertension, affecting nearly half of US adults, is a significant modifiable risk factor for Alzheimer's disease (AD), the fifth leading cause of death among Americans aged 65 and older. Hypertension...

Ambulatory Blood Pressure Characteristics and Target Organ Effects in Hypertensive Children With Renal Artery Variations.

Renal artery variations are recognized as potential contributors to hypertension through altered renal perfusion and activation of renin-angiotensin system. However, their clinical and hemodynamic sig...

Preconception Blood Pressure and Sex of the Baby: A Large Prospective Cohort Study in China.

A recent study suggested an increase in male births associated with maternal preconception high blood pressure. Our objective was to examine this association. Data were obtained from the China-US Coll...

Clinical Risk Assessment of Acute Intermediate-Risk Pulmonary Embolism Using Repeat Transthoracic Echocardiography.

BACKGROUND: Current risk stratification algorithms for intermediate-risk pulmonary embolism (PE) inadequately identify patients who may benefit from escalated care interventions (ECIs) beyond anticoag...

Dynamic Urinary Albumin/Creatinine Ratio Patterns Predict Adverse Outcomes in HFpEF: TOPCAT Cohort Analysis.

BACKGROUND: Urinary albumin-to-creatinine ratio (uACR) is a recognized cardiovascular risk marker, but its dynamic changes in heart failure with preserved ejection fraction (HFpEF) remain underexplore...

Temporal Trends in Mortality Due to Ischemic Heart Disease and Cardiac Arrhythmias in the United States From 1999 to 2023.

BACKGROUND: Ischemic heart disease (IHD) remains a leading cause of mortality in the United States, while arrhythmia-related deaths are increasing. However, long-term mortality trends involving both c...

The impact of gestational diabetes mellitus on mid-pregnancy and infant cardiac morphology and function: A prospective cohort study.

ObjectiveTo evaluate the effects of gestational diabetes mellitus on cardiac morphology and function in fetuses during mid-pregnancy and in infants during the postnatal period.MethodsThis prospective ...

Regional astrocyte dysregulation and altered glymphatic-related markers in Alzheimer's disease frontal cortex.

INTRODUCTION: Astrocyte dysfunction is central to Alzheimer's disease (AD), yet expression patterns of astrocytic markers remain poorly defined. We measured Aquaporin-4 (AQP4) and glial fibrillary aci...

METTL14 Promotes Cuproptosis-Associated Changes in Rats With Myocardial Ischemia-Reperfusion Injury.

To investigate the role and mechanism of METTL14-mediated regulation of cuproptosis in myocardial ischemia-reperfusion injury (MI/RI). An MI/RI rat model was established. H9C2 cells were cultured and ...

Contemporary Management of Aortic Stenosis: Timing of Intervention and Lifetime Valve Management.

BACKGROUND: Calcific aortic stenosis (AS) is the most relevant valvular heart disease in aging populations and remains both underdiagnosed and undertreated. Screening studies reveal a high prevalence ...

Association Between Body Roundness Index and Periodontitis in Adults With Hypertension: A Cross-Sectional Study.

OBJECTIVES: The association between body roundness index (BRI) and periodontitis among US adults with hypertension remains unclear. This study aimed to investigate the relationship between BRI and per...

Atrial Fibrillation Burden and Early Mitral Valve Remodelling in Patients Without Significant Mitral Regurgitation: A 3D Transesophageal Echocardiographic Study.

BACKGROUND: The progression of mitral valve (MV) remodelling in atrial fibrillation (AF) patients without significant mitral regurgitation (MR) remains poorly characterized. We aimed to determine whet...

Anesthetic Management of a Pediatric Patient With Carnitine Deficiency: A Case Report.

Carnitine deficiency syndromes are a group of rare metabolic disorders characterized by impaired β-oxidation and increased reliance on glucose during metabolic stress. Published literature on anesthet...

Serum Albumin Modifies the Prognostic Meaning of BNP in Acute Decompensated Heart Failure.

BACKGROUND: BNP is widely used for risk stratification in acute decompensated heart failure (ADHF), but its prognostic meaning may differ across clinical phenotypes, particularly cardiorenal syndrome ...

Aerobic Endurance Training Modulates Cardiac Renin-Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress.

To investigate the involvement of metalloproteinases (MMPs) in the context of endurance training and their interactions with renin-angiotensin signalling (RAS) in stress-induced pathophysiological res...

Left Atrial Strain Prediction of New-Onset Atrial Fibrillation in Apical Hypertrophic Cardiomyopathy with Cardiac MRI.

Purpose To evaluate the predictive value of cardiac MRI-derived left atrial strain (LAS) for new-onset atrial fibrillation (AF) in apical hypertrophic cardiomyopathy (AHCM). Materials and Methods This...

Prognostic Value of Cardiac MRI-derived Left-to-Right Global Longitudinal Strain Ratio in ST-Elevation Myocardial Infarction.

Purpose To investigate the association between biventricular imbalance, as reflected by the left ventricular (LV) and right ventricular (RV) global longitudinal strain (GLS) ratio derived from cardiac...

Human Myeloid-Derived Growth Factor Induces a Pro-Angiogenic Response and Functional Recovery in a Mouse Model of Peripheral Artery Disease.

Myeloid-derived growth factor (MYDGF) is a monocyte- and macrophage-secreted protein with anti-apoptotic and pro-angiogenic properties that has demonstrated protective effects in models of myocardial ...