Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin-4 Mechanisms.

AIMS: Smoking significantly impairs cognitive function and is a major risk factor for dementia, particularly when initiated during adolescence, a critical period for brain development. The glymphatic ...

Glymphatic Dysfunction in Children With Type 2 and 3 Spinal Muscular Atrophy.

BACKGROUND: Spinal muscular atrophy (SMA) not only causes lower motor neuron degeneration but also affects brain development. Given the role of the glymphatic system in maintaining brain homeostasis d...

Atherogenic Burden and Remnant Cholesterol Associate With Electrophysiological Severity in Carpal Tunnel Syndrome.

BACKGROUND: To investigate whether composite lipid indices and remnant cholesterol (RC) are associated with electrophysiological severity in carpal tunnel syndrome (CTS) and to evaluate their independ...

Evidence for Electrocardiographic Patterns Identifying Acute Coronary Occlusion in Non-ST-Elevation Acute Coronary Syndromes: A Scoping Review.

BACKGROUND: Approximately one-quarter to one-third of patients with non-ST-elevation myocardial infarction have a completely occluded culprit coronary artery but are not routinely referred for emergen...

Comparative Cardiovascular Safety and Exploratory Bleeding Outcomes of Ibrutinib, Acalabrutinib, and Zanubrutinib in Mantle Cell Lymphoma: A Propensity Score-Matched Real-World Analysis.

BACKGROUND: Bruton tyrosine kinase inhibitors are central to the treatment of relapsed or refractory mantle cell lymphoma, but cardiovascular and bleeding toxicities influence treatment selection. Ibr...

Imaging Biomarkers of the Glymphatic System in the Developing Brain.

The glymphatic system is increasingly recognized as a brain-wide pathway that mediates cerebrospinal fluid-interstitial fluid exchange and metabolic waste clearance. However, unlike in adults, its dev...

Subregion-based maximum similarity search registration method for transverse chromatic aberration correction in ultra-widefield scanning laser ophthalmoscopy images.

SIGNIFICANCE: Ultra-widefield scanning laser ophthalmoscopy (UWF SLO), a confocal scanning-based ophthalmic imaging modality widely used in clinical and research ophthalmology, offers an ultra-wide fi...

Polygenic risk scores predict blood pressure changes independent of dietary intervention: a secondary analysis of the NUPRESS trial.

PURPOSE: This study aimed to investigate whether genetic variability, assessed through polygenic risk scores (PRSs), predicts blood pressure (BP) changes in individuals with systemic arterial hyperten...

STIM1-mediated Treg instability in HFpEF: a new immunological target emerges?

Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases and remains a major unmet clinical challenge. Increasing evidence supports the view of HFpEF ...

Cardiac vagal activity during in-vivo threat exposure is associated with within-session inhibition of fear and avoidance.

Laboratory research suggests that the attenuation of defensive responses during threat exposure relies on the inhibition of subcortical defense circuits orchestrated by the prefrontal cortex. This pro...

Routine Capillary Hemoglobin Testing in United Kingdom Commercial Pilot Applicants.

INTRODUCTION: United Kingdom regulations mandate hemoglobin (Hb) testing at each commercial (Class 1) pilot medical examination. The utility of point-of-care finger-prick capillary Hb in determining a...

DIRECT-SIMMONS/DIRECT-TRACE technique for transradial carotid artery stenting using a novel composite-tip guide catheter: a multicenter retrospective study.

To evaluate the efficacy and safety of a novel DIRECT-SIMMONS/DIRECT-TRACE technique utilizing a composite-tip guiding catheter for transradial carotid artery stenting, addressing the limitations of c...

Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression.

The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. Upon investigating the overlap of seemingly divergent reports currently definin...

How Do Sleep Difficulties Interact With Anxiety, Depression and Health-Related Quality of Life in Pulmonary Hypertension?

Sleeping difficulties are prevalent among adults with pulmonary hypertension (PH), with most individuals studied to date reporting poor sleep. However, research investigating the impact of sleep on ps...

Cardiovascular safety of psilocybin in psychiatric practice: a narrative review.

PURPOSE: Psilocybin-assisted interventions are moving from efficacy trials toward psychiatric implementation. Cardiovascular interpretation is central to this transition because trial participants are...

Cross-species functional transcriptomic analysis distinguishes conserved aging-niche remodeling from inflammatory fibroblast heterogeneity in cardiac aging and heart failure.

Cardiac aging is accompanied by inflammatory and extracellular-matrix remodeling, but the extent to which aging-associated fibroblast programs are reproducibly altered in human heart failure remains u...

Visit-to-visit systolic blood pressure variability, blood pressure treatment intensity, and cognitive decline.

INTRODUCTION: Visit-to-visit blood pressure variability (BPV) may be associated with cognitive decline beyond mean blood pressure (BP), but its relevance across treatment contexts remains uncertain. M...

The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.

INTRODUCTION: Vascular risk factors (VRFs) contribute to white matter microstructural degeneration, but their tract-specific contributions are unclear. We assessed the independent associations of four...

Novel Gait Speed Cut-Off Values Associated With Prognosis in Older Patients With Heart Failure.

BACKGROUND: Gait speed is an independent prognostic factor in patients with heart failure (HF) and is recognized as a therapeutic target. Although a single cutoff of 0.98 m/s has been proposed based o...

Impact of Left and Right Bundle Branch Block on Left Ventricular Systolic Function and Myocardial Mechanics Assessed by Speckle-Tracking Echocardiography and Cardiac Magnetic Resonance Feature Tracking: A Systematic Review and Meta-Analysis.

BACKGROUND: Bundle branch conduction abnormalities are associated with ventricular dyssynchrony, impaired myocardial mechanics, and progressive systolic dysfunction. Advanced deformation imaging techn...