The Evolving Landscape of Pulmonary Hypertension Treatment: From Vasodilation to Disease Modification.
Pulmonary hypertension (PH) is a complex disorder associated with significant morbidity and mortality. PH is characterized by an elevated pulmonary vascular load, leading to right ventricular dysfunct...
Plasmapheresis in Hypertriglyceridemia-Associated Acute Pancreatitis: Triglyceride Levels of 5000 mg/dL as a Proposed Threshold.
Severe hypertriglyceridemia-associated acute pancreatitis is a disease with a high mortality rate, and high triglyceride (TG) levels increase the severity of the disease. Standard treatments include f...
The Serum Testosterone Level in Male Patients Is Inversely Associated With Hypertension Incidence.
Hypertension is a primary risk factor for cardiovascular diseases and all-cause mortality. Testosterone, the most potent androgen in males, regulates reproduction, metabolism, and erythropoiesis. Hype...
Hsa_circ_0044097 Serves as a Promising Biomarker of Atherosclerosis and Its Effects on Vascular Smooth Cell Proliferation and Migration.
Atherosclerosis (AS) is closely related to the pathogenesis and abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). To explore the value of hsa_circ_0044097 in the clinical m...
Apigenin, Selenium, and Combinations Are Effective in Preventing 5-Fluorouracil Induced Cardiovascular Damage.
Although chemotherapy is still a widely used primary treatment modality for many cancers, it is an accepted fact that it causes many undesirable side effects and toxicity. Until a new, side-effect-fre...
Automated Echocardiographic Assessment of Left Atrial Remodeling in Atrial Fibrillation Using Dynamic HeartModel and AutoStrain LA.
PURPOSE: To compare left atrial (LA) size, emptying function, and strain among non-atrial fibrillation (AF) controls, patients with paroxysmal AF (PAF), and patients with persistent AF (PeAF) using au...
Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes.
Purpose To evaluate the effects of a monthly 5-day fasting-mimicking diet (FMD) for 1 year on left ventricular (LV) geometry and function in individuals with type 2 diabetes (T2D). Materials and Metho...
Targeting Inflammation in Atherosclerotic Cardiovascular Disease: Mechanisms and Emerging Therapies.
A large body of evidence has helped reframe atherosclerotic cardiovascular disease from a mere lipid storage disorder to a chronic inflammatory disease. Both innate and adaptive immune pathways contri...
Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy.
PURPOSE: To highlight retinal ischemia as an important component of diabetic retinopathy (DR) pathogenesis, a significant prognostic factor, and a driver of various DR complications, including neovasc...
[Management of oral anticoagulant therapy after catheter ablation of atrial fibrillation].
In recent years, catheter ablation for atrial fibrillation (AF), particularly pulmonary vein isolation, has become an increasingly used and evidence-based treatment aimed primarily at improving sympto...
Evaluation of motion correction on myocardial [(1) (8)F]F-AraG PET uptake using data-driven respiratory gating.
BACKGROUND: [1 8F]F-AraG (radio-fluorinated 9-β-D-arabinofuranosylguanine) is a PET radiotracer for imaging T-cell activation with emerging applications in myocardial imaging. Cardiac PET is particula...
Inferior Vena Cava Ultrasound Does Not Reliably Estimate Systemic Venous Pressure in Adults With a Fontan Circulation.
PURPOSE: Current ASE/EACVI echocardiography guidelines recommend estimating central venous pressure from inferior vena cava (IVC) diameter and collapsibility in biventricular circulations. Because alt...
Left Ventricular Mechanics and Myocardial Work in Competitive Sprinters.
BACKGROUND: Sprint exercise is characterized by repeated short-duration high-intensity anaerobic activity associated with distinct hemodynamic and autonomic adaptations. However, the effects of long-t...
The Impact of Lipoprotein apheresis on Plasma Protein Levels: A Meta-Analysis.
Lipoprotein apheresis (LA) is used for severe dyslipidemia but can remove non-lipid plasma constituents. In this systematic review and meta-analysis, we synthesized evidence on LA-associated changes i...
Cardiac Myxoma Originating From the Septal Papillary Muscle of the Right Ventricle in a Second-Trimester Patient.
This case illustrates a large right ventricular myxoma causing severe right ventricular outflow tract obstruction. Multimodality imaging, including echocardiography and CT, guided the diagnosis. The p...
Peripartum Cardiomyopathy in a Woman Who Conceived Shortly After Bariatric Surgery: A Case Report.
Peripartum cardiomyopathy (PPCM) is a rare but potentially fatal form of heart failure occurring in the peripartum period without an identifiable cause. We report the case of a 36-year-old woman who c...
Notoginsenoside R1 Alleviates Macrophage Inflammatory Responses via Modulating the JAK1/STAT3 Pathway.
Notoginsenoside R1 (NR1), an active component of Panax notoginseng, may exert anti-atherosclerotic effects by modulating macrophage M1/M2 polarization. This study aimed to investigate the specific mec...
Plantar Foot Microvascular Reactivity and Oxygenation in Type 2 Diabetes and Peripheral Artery Disease: An Exploratory Study.
OBJECTIVE: Microvascular dysfunction contributes to foot complications in type 2 diabetes (T2D) and peripheral artery disease (PAD), yet has been characterized primarily in non-plantar regions. We eva...
The risk of cardiovascular events in metabolic dysfunction-associated steatotic liver disease according to fibrosis stage and diabetes status: A cohort study.
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality in metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated whether fibr...
Dementia Risk With Combined Statin and Antihypertensive Drugs That Increase Versus Decrease Angiotensin-II Formation: Findings From the 45 and Up Study.
BACKGROUND: Hypertension and dyslipidaemia are key modifiable risk factors of dementia, and the combined use of statins and antihypertensive medications (AHMs) may offer protective benefits. However, ...