SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy.

BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are now widely applied in treatment plans for heart failure with reduced ejection fraction (HFrEF) patients, regardless of the presence o...

Body mass index predicts ventricular repolarisation in obese children: differential effects across obesity levels.

BACKGROUND: Childhood obesity is associated with cardiac electrical remodelling, yet the relationship between body mass index (BMI) and ventricular repolarisation (VR) heterogeneity remains incomplete...

Association and causality between triglycerides and hypertension: evidence from NHANES 2007-2018 and two-sample Mendelian randomisation analysis.

BACKGROUND: Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear ...

Aggressive surgical approach in diffuse coronary artery disease: coronary endarterectomy and early- to mid-term outcomes.

AIM: In patients with diffuse coronary artery disease (CAD), the absence of a suitable distal target vessel for standard coronary artery bypass grafting (CABG) is the main factor limiting the success ...

Low versus high inferior mesenteric artery ligation and gastrointestinal quality of life following anterior resection for rectal cancer.

AIM: To assess whether the level of inferior mesenteric artery (IMA) ligation independently affects gastrointestinal-specific quality of life after anterior resection for rectal cancer. METHODS: A pro...

Systemic Neutralization of Granulocyte-Macrophage Colony-Stimulating Factor Attenuates Stellate Ganglion Neuroinflammation and Cardiac Sympathetic Overactivation in Chronic Heart Failure in Rats.

Chronic heart failure (CHF) is characterized by heightened cardiac sympathetic activity and neuroinflammation within the stellate ganglia (SG), contributing to cardiac arrhythmogenesis. However, the u...

Racial outcomes in patients with diabetic cardiomyopathy treated with an aldose reductase inhibitor: the ARISE-HF trial.

BACKGROUND: Racial and ethnic differences in diabetic cardiomyopathy (DbCM) exist, with black and Hispanic participants showing poorer health status. It remains unclear whether these differences affec...

Genetic ancestry and risk of atrial fibrillation in individuals of Black ethnicity in the UK Biobank.

BACKGROUND: Black individuals have a lower incidence of atrial fibrillation (AF) than White individuals, despite a higher burden of traditional risk factors. Prior studies have suggested that European...

Safe cochlear implantation in a child with Wolff-Parkinson-White syndrome.

Wolff-Parkinson-White (WPW) syndrome is a congenital cardiac conduction abnormality. It is characterised by ventricular pre-excitation that arises from abnormal electrical conduction through an access...

Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation.

BACKGROUND: The premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by de novo LMNA mutations producing the aberrant Lamin A isoform progerin. HGPS patients die from cardiov...

Combined carotid endarterectomy and bypass for multi-level supra-aortic occlusive disease.

Occlusion of the subclavian artery is an important cause of upper limb ischaemia and vertebrobasilar insufficiency. When associated with carotid artery occlusion, management becomes complex and techni...

Association between non-HDL-C and nonalcoholic fatty liver disease (NAFLD) in adults aged 20 years and older: A population-based study in western China.

Dyslipidemia negatively impacts the development of nonalcoholic fatty liver disease (NAFLD); yet, the specific relationship between non-high-density lipoprotein cholesterol (non-HDL-C) and NAFLD has n...

Exploration and prospect of core research hotspots in sepsis-induced myocardial injury based on bibliometrics.

OBJECTIVE: Sepsis-associated myocardial injury (SICM) is one of the most common and severe complications of sepsis. The present study aimed to analyze research trends, collaborative networks, and know...

Knowledge mapping of targeted therapy for hypertrophic cardiomyopathy: A bibliometric analysis of myosin inhibitor research.

BACKGROUND: Targeted therapy using myosin inhibitors represents a groundbreaking advancement in the management of hypertrophic cardiomyopathy (HCM). This study conducts a comprehensive bibliometric an...

Glycemic variability, atherosclerosis, and arterial stiffness in persons with type 2 diabetes mellitus: A Mendelian randomization and epidemiologic study.

This study aimed to investigate the relationships between visit-to-visit variability in HbA1c and fasting plasma glucose (FPG) and atherosclerotic markers in persons with type 2 diabetes mellitus (T2D...

Wearable Devices for Monitoring and Management of Comorbid Obstructive Sleep Apnea and Hypertension: Scoping Review.

BACKGROUND: As an established driver of hypertension, obstructive sleep apnea (OSA) generates a significant cardiovascular burden when both disorders are present. This intersection not only compromise...

Associations of dietary inflammatory and antioxidant indices with mortality in adults with cardiovascular-kidney-metabolic syndrome: A mediation analysis.

Cardiovascular-kidney-metabolic (CKM) syndrome carries high mortality risk. Whether A Body Shape Index (ABSI), Weight-Adjusted Waist Index (WWI), Systemic Inflammation Response Index (SIRI), and Syste...

Admission serum bicarbonate is associated with early diuretic resistance in acute decompensated heart failure.

BACKGROUND: Acute decompensated heart failure (ADHF) exhibits a heterogeneous diuretic response. Chloride-bicarbonate imbalances may reduce loop diuretic efficiency. The effect of admission bicarbonat...

A meta-analysis of randomized controlled trials on atenolol's impact on postoperative atrial fibrillation in adults undergoing cardiac surgery.

Prior research has conducted a limited number of studies on the efficacy of atenolol in preventing atrial fibrillation following cardiac surgery (CS). Consequently, a comprehensive evaluation and meta...

Target-centered network pharmacology and molecular docking reveal potential mechanisms and bioactive compounds of Zhigancao Decoction in insomnia-Arrhythmia comorbidity.

This study aimed to investigate the potential mechanisms of Zhigancao Decoction (ZGCT) in insomnia-arrhythmia comorbidity using a target-centered network pharmacology and molecular docking approach. I...