Cardiac function in zebrafish embryos is linked to an androgen receptor-adrenomedullin-proepicardium axis.
BACKGROUND: Congenital heart defects (CHDs) comprise the most common congenital malformation affecting nearly 1% of all newborns. In individuals with sex chromosome aneuploidy syndromes, however, the ...
Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study.
OBJECTIVES: The intrauterine environment may influence childhood immune-mediated disease risk. We investigated whether maternal prepregnancy body mass index (BMI), gestational weight gain (GWG) or hyp...
Anakinra for intravenous immunoglobulin-resistant Kawasaki disease: a systematic literature review.
BACKGROUND: Approximately 10%-20% of patients with Kawasaki disease (KD) are resistant to intravenous immunoglobulins (IVIG) and are at increased risk of developing coronary artery aneurysms (CAA). A ...
Patterns and trends of mortality in patients with arrhythmia and cerebrovascular disease in the United States: a nationwide analysis of older adults.
Arrhythmias and cerebrovascular disease commonly coexist in older adults and are associated with increased mortality risk. However, population-level trends and demographic disparities in related death...
Effectiveness and safety of acetazolamide plus loop diuretics in acute congestive heart failure: A living systematic review - Version 2026 1.0.
OBJECTIVE: This living systematic review Version 1.0 aims to provide a timely, rigorous and continuously updated summary of the evidence on the use of acetazolamide plus loop diuretics in acute conges...
Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders.
Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...
Application of glutamine metabolism-related gene signatures in the non-invasive diagnosis of coronary artery disease: integrating bulk and single-cell transcriptomics.
Coronary artery disease (CAD) is a common cardiovascular disorder strongly associated with glutamine metabolism. This study seeks to identify novel glutamine metabolism-related gene markers in CAD. Ba...
Heart Failure with Preserved Ejection Fraction in Women: Sex-Specific Insights Across the Continuum from Diagnosis to Outcomes.
PURPOSE OF REVIEW: This review highlights differences in pathophysiologic mechanisms, diagnostic challenges and therapeutic responses of heart failure with preserved ejection fraction (HFpEF) in women...
Association between kidney stones and major adverse cardiovascular events: a population-based analysis.
Kidney stones are an increasingly common condition, and evidence suggests a link between stone formation and cardiovascular risk. This study aimed to investigate the association between kidney stones ...
Peroxisome Proliferator-Activated Receptor Delta (PPARδ) as a Metabolic Gatekeeper of Cerebrovascular Integrity.
The peroxisome proliferator-activated receptor delta (PPARδ) is a nuclear receptor highly expressed in vasculature and serves a central role in coordinating vascular and metabolic homeostasis across m...
Post-translational modification crosstalk in pulmonary arterial hypertension: mechanisms and therapeutic implications.
Pulmonary arterial hypertension (PAH) is a complex vascular disease characterized by endothelial dysfunction, pulmonary arterial smooth muscle cell (PASMC) hyperproliferation, metabolic reprogramming,...
Ventricular Assist Device Use in Single Ventricle Heart Disease: Current Outcomes and Considerations.
PURPOSE OF REVIEW: Heart failure in patients with congenital heart disease and particularly single ventricle physiology at all stages of palliation presents significant management challenges. Ventricu...
Surgical relief of supravalvular aortic stenosis.
A 10-month-old girl (72 cm, 8.86 kg) with an antenatal diagnosis of supravalvular aortic stenosis attributable to a maternally inherited elastin gene (7q11.23) deletion underwent elective repair of su...
Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications.
Valvular cardiomyopathy has emerged as a key concept linking valvular heart disease (VHD) with myocardial remodeling and the development of heart failure (HF). This state-of-the-art review provides a ...
A physics-informed eikonal model for simulating arrhythmias in the human heart in real-time.
Personalized computational models of cardiac electrophysiology, referred to as cardiac digital twins, are considered a key technology for realizing precision cardiology by tailoring therapies to indiv...
Chronotype and Atherogenic-Adiposity Indices in Adults Without Previously Diagnosed Chronic Disease: A Sex-Aware Cross-Sectional Study.
Background and Objectives: Chronotype and sleep quality are related but non-identical dimensions of sleep health. We examined whether later chronotype is associated with subclinical visceral adiposity...
A Complex Arrhythmic Phenotype in a Pediatric Patient with Variants in SCN5A and KCNH2.
Long QT Syndrome type 2 (LQT2) and Brugada syndrome are inherited cardiac channelopathies that predispose affected individuals to ventricular arrhythmias and sudden cardiac death. We report the case o...
Structure-Aware OCTA Segmentation for OCTA-Derived Quantitative Analysis of Cerebral Microvascular Perfusion in Ischemic Stroke.
Background: Ischemia-related optical coherence tomography angiography (OCTA) signal degradation complicates cerebral vessel segmentation and quantitative analysis. We developed a structure-aware segme...
Jingling Granules alleviate atherosclerosis through activating autophagy and inhibiting human umbilical vein endothelial cells apoptosis.
Atherosclerosis (AS) remains a leading cause of cardiovascular morbidity worldwide. Strategies that promote autophagy and limit apoptosis hold therapeutic promise. Jingling Granules (JLG), a clinicall...
Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.
BACKGROUND: Obesity is widely recognized as an aggravating risk factor for atherosclerosis (AS), yet the effects of obesity on AS-associated microbiome dysbiosis are not sufficiently characterized. Th...