Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy.

Heart failure is a leading cause of mortality, and impaired cardiac excitation-contraction coupling represents a potentially fatal trigger for myocardial dysfunction. Long non-coding RNAs (lncRNAs) ca...

Transcriptomic landscape of human cardiac aging: identification of cardioselective age-associated genes and predictive modeling.

Age is a major risk factor for cardiovascular disease, yet the molecular mechanisms underlying human cardiac aging are not fully understood. Using bulk RNA sequencing data from the Genotype-Tissue Exp...

A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging.

BACKGROUND Apical hypertrophic cardiomyopathy (ApHCM), also known as Yamaguchi syndrome, is a rare variant of hypertrophic cardiomyopathy characterized by the thickening of the left ventricle apex (>1...

Diverticulitis-Associated Mesenteric Venous Thrombophlebitis: A Case Report and Systematic Review of Diagnosis, Management, and Outcomes.

Diverticulitis can rarely seed the portal‑mesenteric venous system, causing septic thrombophlebitis with morbidity and management uncertainty. This study systematically reviewed diverticulitis‑associa...

[A brief analysis of the core component of the meridian system from an anatomical perspective].

Through a brief review of early meridian theories and their historical development, it is deemed that anatomical evidence played a pivotal role in the formation and evolution of the theory of meridian...

[Electroacupuncture improves myocardial ischemia inflammatory injury by regulating the homeostasis of myocardial Th17/Treg cells through JAK1/STAT3 signaling in rats].

OBJECTIVES: To observe the effect of electroacupuncture (EA) on the homeostasis of Th17/Treg cells and the expressions of key proteins of the janus kinase 1/signal transducer and activator of transcri...

[Clinical characteristics of pregnant women with different high-risk factors for Stanford type A aortic dissection].

Objective: To analyze the clinical characteristics of pregnant women with different risk factors of Stanford type A aortic dissection (TAAD), so as to provide evidence for early warning and stratified...

A Systematic Review of the Role of Recreational Activities and Dietary Management in Treating Hypertension and Hyperglycaemia in Adults in Low- and Middle-Income Countries.

In low- and middle-income countries, the burden of hypertension and hyperglycaemia is alarming. These conditions remain major, recurring public health concerns that demand alternative healthcare strat...

Resting Tissue Doppler Imaging for Detecting Coronary Artery Disease in Patients with Preserved Ejection Fraction and No Wall Motion Abnormalities.

Background and Objectives: Coronary artery disease may be difficult to detect by resting echocardiography when left ventricular ejection fraction is preserved and regional wall motion abnormalities ar...

Identification of Pyroptosis-Related Gene Signatures Associated with Predicted Immune-Cell Enrichment in Atrial Fibrillation.

Background: Research demonstrates that pyroptosis is a critical factor in the progression of cardiovascular diseases and their related complications. Nevertheless, the precise association between this...

Transcript-aware rare genetic variant association analyses of cardiopulmonary traits in participants from the All of Us Research Program.

Gene-based rare variant analyses often lack statistical power and may overlook transcript-specific effects. Here, we present a transcript-aware aggregation framework. In simulation studies, the framew...

Protective Effect of Natural Phenolic Acids, Rosmarinic Acid and Salvianolic Acid, Against Diabetic Atherosclerosis.

Cardiovascular disease (CVDs) and atherosclerosis remain a major causes of morbidity and mortality worldwide. Endothelial dysfunction is a central driver of atherosclerosis, which is significantly acc...

Analysis of Matrix Metalloproteinase-8 Gene Polymorphisms and Their Association with Long-Term Survival, Clinical Phenotype, and Disease Risk in Patients with Coronary Artery Disease.

Matrix metalloproteinase-8 (MMP-8), a neutrophil-derived collagenase responsible for the degradation of type I and III collagen, is involved in extracellular matrix remodeling, which may contribute to...

Targeting Kinase Signaling in Glioblastoma: Structural Optimization, Blood-Brain Barrier Dynamics and Combinatorial Translational Strategies.

Small-molecule kinase inhibitors offer a compelling therapeutic strategy for glioblastoma, yet their clinical efficacy remains severely limited by blood-brain barrier penetration and active efflux tra...

Interventional Tricuspid Valve Replacement: A Structured Sequence of Procedures.

The EVOQUE valve system is the first approved tricuspid valve replacement system developed specifically for the percutaneous implantation of a biological tricuspid valve in patients diagnosed with sym...

Real-Time Two-Photon Imaging of Brain Endothelial NAD+ Metabolism in Mice.

We present a reproducible workflow for real-time visualization of nicotinamide adenine dinucleotide (NAD+) biosensor-channel responses in brain microvascular endothelial cells in living mice using cra...

Between data and touch: how nurses and patients negotiate the human boundary under data-driven surveillance in chronic care.

BACKGROUND: The integration of data-driven continuous monitoring into chronic disease management is often presented as a solution for clinical efficiency. However, this technological shift may substan...

Relationship Between Dietary Inflammatory Index With Biochemical Markers and Atherogenic Risk in Patients With Atherosclerotic Heart Disease.

AIMS/BACKGROUND: The relationship between cardiovascular disease and the inflammatory potential of diet has been recently reported. This study aimed to investigate the relationship between a pro-infla...

How to Safely Anticoagulate Patients With Renal Impairment.

Chronic kidney disease (CKD), a highly prevalent condition worldwide, is associated with increased thrombotic and bleeding risks. Thrombotic risks include heightened cardiovascular risk and that of ve...

Association of the cardiometabolic index and depressive symptoms with cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.

The progressive nature of cardiovascular-kidney-metabolic syndrome (CKM) allows early intervention during stages 0-3. However, the role of the cardiometabolic index (CMI) across CKM stages 0-3 and its...