miR-138-5p Inhibits Aortic Valve Interstitial by Targeting SLC39A14 and Activating Nrf2 Signaling.
This study explored the role of miR-138-5p in calcific aortic valve disease (CAVD), focusing on its regulation of osteogenic differentiation in human aortic valve interstitial cells (hAVICs) and under...
Genotype-Dependent Effects of Mechanical Stretch and GATA4-Targeted Compound 3i-1262 in Cardiomyopathy Patient-Derived hiPSC-Cardiomyocytes.
Genetic hypertrophic and dilated cardiomyopathies (HCM and DCM, respectively) are characterised by structural and functional abnormalities that can lead to heart failure. However, current therapies ma...
Validation of the Arabic Version of Patient Health Questionnaire-9 in Omani and Yemeni Patients With Chronic Physical Diseases.
BACKGROUND: Secondary depression frequently develops in people with chronic diseases, and it may hinder disease progress and treatment outcomes. This study aimed to examine the construct validity and ...
A systematic mapping review of studies reporting the effects of spaceflight on cardiovascular outcomes.
This systematic review aimed to characterize the landscape of cardiovascular research in the context of spaceflight and its Earth-based analogs. In collaboration with subject matter experts from the A...
Sex differences in regulatory mechanisms of the cardiovascular system during simulated hypokinesia.
The study examined sex-specific differences in the autonomic response to simulated hypokinesia. Nine healthy males (23±3 years) and nine females (26±3 years) underwent 5‑day dry immersion. Heart rate ...
The mechanism and protection of microgravity induced cardiac remodeling.
Prolonged exposure to a microgravity setting results in alterations to the hearts of astronauts. While multiple studies have documented the impact of microgravity on cardiovascular well-being, there i...
On the History of Hepatic Vein Catheterization.
Hepatic vein catheterization (HVC) in man was first performed 80 years ago in the wake of right-sided heart catheterization. Several new methods, recognitions and concepts followed, especially the ind...
The Case for Gulf Region-Specific Peripheral Artery Disease Trials: A Comprehensive Literature Review.
Peripheral artery disease (PAD) research is globally underrepresented, with landmark trials like Best Endovascular Surgical Therapy for Patients with Critical Limb Ischemia and Bypass versus Angioplas...
Long-Term Persistence and Treatment Changes of Antihypertensive Therapy: A 5-Year Cohort Study.
AIM: To estimate persistence with antihypertensive therapy (AHT) and describe treatment changes and associated factors among persistent patients over 5 years. METHODS: We conducted a longitudinal coho...
Comparison of Complications According to the Number of Venous Anastomoses in Lower Extremity Reconstruction.
BACKGROUND: Venous congestion remains a leading cause of early free flap failure in lower extremity reconstruction. Although double venous anastomosis has been proposed to enhance venous outflow, its ...
The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis.
In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of...
Intensive blood pressure lowering after spontaneous intracerebral haemorrhage for secondary stroke prevention (RECAP-ICH): a systematic review and individual participant data meta-analysis.
BACKGROUND: Blood pressure-lowering treatment prevents stroke after spontaneous intracerebral haemorrhage. However, there is uncertainty over the consistency of the effects across clinically relevant ...
Cholinesterase inhibitors in people with dementia with Lewy bodies and cardiac conduction abnormalities.
Bradycardia due to cardiac conduction abnormalities is prevalent in patients with dementia with Lewy bodies possibly due to autonomic dysfunction and neurodegeneration. Cholinesterase inhibitors remai...
The Association Between Atherogenic Index of Plasma and Type 2 Diabetes Mellitus in a Multi-Ethnic Population of Premature Coronary Artery Disease Patients: Insights From IPAD Study.
BACKGROUND: The atherogenic index of plasma (AIP) is a lipid-based indicator of cardiometabolic risk. We examined whether AIP is associated with prevalent type 2 diabetes mellitus (T2DM) and fasting b...
Patient Selection, Referral Framework and Emerging Therapies in Severe Ischemic Heart Failure: A State-of-the-Art Review.
Chronic or severe ischemic heart disease can lead to damaged or infarcted myocardium that can progress to heart failure. When evaluating revascularization, one should consider noninvasive assessments,...
Patient Selection, Referral Timing, and Advanced Heart Disease Therapy Options for Heart Failure with Reduced Ejection Fraction.
Advanced heart failure is characterized by persistent severe symptoms and functional limitations despite optimal medical therapy and carries significant morbidity and mortality. This article discusses...
Cardiac Contractility Modulation: Implications in Heart Failure, a Current Review.
Cardiac contractility modulation (CCM) is a novel therapeutic approach for heart failure patients, which utilizes nonexcitatory electrical myocardial stimulation in the absolute refractory period of t...
Baroreflex Activation Therapy in Patients with Heart Failure with a Reduced Ejection Fraction.
A randomized, controlled trial of baroreflex activation therapy (BAT) in patients with heart failure and reduced ejection fraction demonstrated that BAT was safe and significantly improved patient-cen...
Remote Monitoring Devices and Heart Failure.
Remote patient monitoring (RPM) in patients with heart failure (HF) involves transmitting physiological data from devices to a health-care provider via a wireless connection with targeted intervention...
Approach to Ventricular Arrhythmias in Heart Failure.
Ventricular arrhythmia remains a challenge in the heart failure population, resulting in significant morbidity and mortality despite modern heart failure therapies. Patients with heart failure who hav...