Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.
BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used as an adjunct in haemorrhagic shock (HS) to restore proximal perfusion. Its cerebral metabolic effects during haem...
Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.
Left atrial remodeling (LAR) critically contributes to the progression of heart failure (HF) and the development of atrial fibrillation (AF) following myocardial infarction (MI). The protein α2δ1, pri...
[PRDX1 attenuates hypertensive endothelial dysfunction by inhibiting mTOR/p70S6K signaling].
Objective: To explore the role and molecular mechanism of peroxiredoxin 1 (PRDX1) in hypertension-induced endothelial dysfunction. Methods: (1) Bioinformatics analysis: A total of 40 C57BL/6J mice age...
[A case of zero-contrast cardiac resynchronization therapy defibrillator implantation].
扩张型心肌病合并慢性心力衰竭、完全性左束支传导阻滞的患者，通常面临猝死风险，因此需要置入心脏再同步化治疗除颤器进行一级预防。置入术需常规冠状静脉窦造影，对于明确碘造影剂过敏或严重肾功能不全患者存在较大风险。该文报道1例采用零造影剂策略成功实施心脏再同步化治疗除颤器置入术的病例，为该类患者提供了一定的经验和依据。.
[The role and mechanism of transient receptor potential M2 channel-mediated calcium homeostasis imbalance in the development of diabetic cardiomyopathy].
糖尿病心肌病是糖尿病患者发生心力衰竭的重要原因，而细胞内钙稳态失衡是驱动心肌损伤与心室重构的核心病理环节。瞬时受体电位M2通道作为一类具有Ca²⁺非选择性通透性的阳离子通道，是连接氧化应激与代谢紊乱的关键调控分子。该文主要介绍瞬时受体电位M2通道在糖尿病心肌病钙稳态失衡中的作用及相关分子机制，明确该通道可能成为糖尿病心肌病的潜在治疗靶点，以期为糖尿病心肌病的防治提供新的思路与方向。.
[New progress in diagnosis and treatment of hypertrophic cardiomyopathy with left ventricular apical aneurysm].
肥厚型心肌病（HCM）合并左心室心尖部室壁瘤是HCM的重要亚型，多见于左心室中部梗阻的患者，易引发血栓栓塞、恶性心律失常、心力衰竭甚至心脏性猝死等不良事件，患者预后不佳。因此，对此类患者开展早期识别并及时采取干预和治疗，对延缓病情发展、改善临床预后具有重要意义。该文就HCM合并左心室心尖部室壁瘤的发生机制、诊断方法、预后评估及治疗策略等方面的研究进展进行综述，以期为该特殊亚型的临床诊疗与管理提供参...
[Incremental value of CMR for the 2025 appropriate use criteria of ICD implantation in sudden cardiac death risk stratification of dilated cardiomyopathy].
Objective: To evaluate the predictive value of the 2025 appropriate use criteria (AUV) for implantable cardioverter defibrillators (ICD) jointly issued by the American College of Cardiology/American H...
[Expert advisory on screening and diagnosis of inflammatory risk in coronary artery disease].
冠心病是全球疾病负担最重和导致死亡的主要原因之一，在积极降脂治疗的背景下，炎症风险已被证实为冠心病患者心血管事件的重要预测因素。近年来，随着抗炎治疗临床证据的积累，尤其是秋水仙碱等药物在冠心病二级预防中获益已被确证，炎症管理正逐步成为冠心病综合防治的新方向。在此背景下，中华医学会心血管病学分会心血管免疫与炎症学组联合心血管指南与共识学组、动脉粥样硬化与冠心病学组、中华心血管病杂志编辑委员会，基于最...
[Optimized antithrombotic therapy for coronary artery disease: current status and future perspectives].
抗栓治疗是冠心病综合管理的核心环节，直接决定患者缺血与出血风险的平衡及远期临床预后。近年来，随着新药研发、治疗策略迭代与风险评估技术进步，冠心病抗栓治疗正从传统标准化方案转向精准化、个体化模式。该文围绕新型抗栓药物研发进展、抗栓治疗策略革新、缺血与出血风险预测模型构建等方面，系统梳理该领域现状，剖析关键挑战，并对未来发展方向进行述评，为临床实践与科学研究提供参考。.
[Clinical characteristics, antithrombotic therapy, and prognosis of new-onset atrial fibrillation in the acute phase of ST-segment elevation myocardial infarction].
Objective: To investigate the clinical characteristics and antithrombotic treatment strategies in patients with acute ST-segment elevation myocardial infarction (STEMI) who develop new-onset atrial fi...
[A case of esophagoleft atrial fistula mixed with infective endocarditis].
该文报道1例老年女性患者，因鱼骨所致食管损伤继发食管-左心房瘘，合并缓症链球菌与热带念珠菌混合感染性心内膜炎。患者外院曾误诊为左心房血栓，经增强CT检查提示心腔积气，最终经左心房食管瘘修补术联合赘生物清除术得以确诊。该文围绕心腔积气的影像学预警价值、病原菌谱特点、长疗程抗感染与抗真菌策略、手术时机选择及围手术期多学科管理进行探讨。.
Retrospective Evaluation of Recombinant Human Brain Natriuretic Peptide Therapy for Decompensated Right Heart Failure Across Pulmonary Hypertension Groups.
Background and Objectives: Right heart failure is a life-threatening complication of pulmonary hypertension (PH), with limited treatment options. Although recombinant human brain natriuretic peptide (...
TRPV1 Activation Is Associated with Improved Mitochondrial Function and Cardioprotection in Experimental Hypertension.
Background: Systemic arterial hypertension (SAH) induced by Nω-nitro-L-arginine methyl ester (L-NAME) is a well-established model characterized by nitric oxide (NO●) synthase inhibition and vascular d...
Mechanistic Role of Sestrin2 in Exercise-Mediated Cardioprotection Against Obesity-Related Cardiomyopathy.
Exercise is one of the safe and effective methods to improve obesity and its complications, but the mechanism has not been fully elucidated. Sestrin2 (SESN2) is a stress-induced protein that protects ...
Impact of Ca(V)1.3 L-Type Calcium Channels on Arrhythmogenesis in Cancer.
Cardiovascular disease and cancer remain the leading causes of death worldwide. Although numerous cancer therapies have improved survival rates, they also increase the risk of cardiomyopathy, heart fa...
ECG Signal Compression and Reconstruction Based on CNN-LSTM-Attention Model.
The high prevalence of cardiovascular diseases and the extensive application wearable electrocardiogram (ECG) devices for long-term monitoring have posed significant challenges for the transmission, s...
Synergistic Effect of Hypertension and Smoking on Ischemic Stroke Risk: A Case-Control Study With Additive and Multiplicative Interaction Analysis.
Ischemic stroke remains a leading cause of death and disability worldwide. This single-center retrospective case-control study evaluated the independent and interactive effects of smoking, alcohol con...
Standardized Protocol for Intravascular Ultrasound-Guided Lithotripsy in Severely Calcified Coronary Lesions.
Severe coronary artery calcification poses a clinical challenge during percutaneous coronary intervention, significantly increasing the risk of stent underexpansion and subsequent adverse cardiovascul...
Immunometabolic Mechanisms of Coronary Microvascular Dysfunction in Coronary Artery Disease: The Role of Mitochondrial Stress, Endothelial Senescence, and Regulated Cell Death.
Chronic coronary syndromes (CCSs) are increasingly recognized as complex immunometabolic vascular disorders in which coronary microvascular dysfunction (CMD), persistent low-grade inflammation, oxidat...
Ductus arteriosus aneurysm in a neonate with inspiratory stridor.
BACKGROUND: Inspiratory stridor in neonates is typically attributable to laryngomalacia, vocal cord paralysis, or subglottic stenosis. Less commonly, vascular anomalies can cause inspiratory stridor. ...