The Research Progress in Targeted Therapy for Hypertension via Heat Shock Proteins.

As the core molecular chaperones of the cellular stress response, the heat shock protein (HSP) family has gained extensive attention for its role in the occurrence, development, and target organ damag...

The Effect of Zinc Sulfate Treatment on Diabetic Cardiomyopathy in an Aged Female Rat Model of Type 2 Diabetes.

Background/Objectives: Diabetic cardiomyopathy (DCM) is largely driven by severe oxidative stress and calcium dyshomeostasis. We examined the targeted antioxidant and therapeutic effects of zinc sulfa...

Association of Ascending Aortic Aneurysm with NOX4 and miRNA 146a.

Objective: To evaluate the efficacy of NADPH oxidase 4 and miR-146a-5p in current treatment planning for ascending aortic aneurysms, independent of aortic diameter, and to develop protocols that will ...

[Lactate induces gastric mucosal injury by promoting M1 polarization of macrophages via the cardio-gastric axis].

OBJECTIVES: To investigate the role of lactate in myocardial ischemia-reperfusion (MIR)-induced gastric mucosal injury. METHODS: Thirty C57BL/6J mice were randomized into sham-operated group, MIR (45 ...

Tongmai Yangxin pills alleviate myocardial ischemia-reperfusion injury by enhancing mitochondrial function via activating the ERK signaling pathway.

BACKGROUND: To explore the mechanism of Tongmai yangxin pills (TMYX) for improving myocardial ischemia-reperfusion injury (MIRI) in rats. METHODS: In a SD rat model of MIRI, the therapeutic effects of...

[Targeted inhibition of miR-503 upregulates Apelin expression to alleviate myocardial infarction in mice].

OBJECTIVES: To investigate the effect of inhibiting miR-503 on myocardial infarction (MI) and clarify its upstream regulatory factors and downstream effector pathways to identify potential therapeutic...

MLK3 promotes atherosclerosis by regulating ferroptosis in macrophages.

BACKGROUND: Atherosclerosis (AS) is the leading cause of cardiovascular death worldwide. Macrophage ferroptosis is implicated in AS progression. The precise mechanism by which mixed lineage kinase 3 (...

Computational modeling of stent failure during crimping and deployment in coronary arteries.

Crimping and deployment of coronary stents involve severe finite deformations, multibody contact, and complex loading-unloading sequences that critically influence their structural integrity and long-...

Immunomodulatory Effects of Propolis on Endothelial Cytokine Release.

Propolis is a natural resinous product with a broad spectrum of biological activities, including immunomodulatory and anti-inflammatory effects. Increasing evidence suggests that propolis may influenc...

Prognostic value of dobutamine stress echocardiography: A South African experience.

BACKGROUND: Dobutamine stress echocardiography (DSE) is a well-established modality for the diagnosis and risk-stratification of coronary artery disease, but no prognostic data have been reported from...

Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis.

Autoimmune myocarditis frequently progresses to inflammatory cardiomyopathy through dysregulated immune-stromal interactions. This study employs single-nuclei RNA-sequencing (snRNA-seq) to profile 46,...

Neuroinflammation in Alzheimer's Disease (AD) and Glioblastoma (GBM): Shared Mechanisms and Therapeutic Insights.

INTRODUCTION: Neuroinflammation is a key feature of both Alzheimer's disease (AD) and glioblastoma, although it leads to different outcomes in each disorder. In AD, chronic activation of microglia and...

Study on diagnostic genes and immune microenvironment disorder in comorbid atherosclerosis and Alzheimer disease.

Atherosclerosis (AS) and Alzheimer disease (AD) are globally prevalent chronic diseases with challenges of difficult early diagnosis and a lack of effective combined therapies. This study explored the...

Association of family history of hypertension with preventive attitudes and quality of life in turkish population: A cross-sectional study.

Hypertension is more common among patients with a family history of hypertension (FHH). However, it is not known whether FHH is associated with hypertension-preventive attitudes in normotensive indivi...

Muscle quality index is associated with advanced stages in patients with cardiovascular-kidney-metabolic syndrome: A cross-sectional study.

Cardiovascular-kidney-metabolic (CKM) syndrome represents a complex systemic condition involving interconnected dysfunctions across metabolic, renal, and cardiovascular systems, presenting significant...

A nomogram for risk prediction in patients with heart failure and diabetes: Development and validation.

Heart failure (HF) commonly coexists with type 2 diabetes mellitus (T2DM), and this combination is linked to a heavier symptom burden and less favorable clinical outcomes. In this retrospective single...

Acupuncture for cardiac arrhythmias: A systematic review and meta-analysis.

BACKGROUND: Arrhythmia is common, and some patients respond poorly or experience adverse reactions to standard cardioversion therapies, highlighting the need for safer adjunctive options. Although acu...

Protective effect of absent Hyrtl anastomosis on fetal prognosis in monochorionic twins: Report of 2 cases and literature review.

RATIONALE: Hyrtl anastomosis is an intra-arterial shunt between umbilical arteries, which exerts a protective effect by balancing arterial pressure in singleton pregnancies. Its absence may be associa...

Can shortening the waiting time for gestational hypertension and preeclampsia during labor reduce adverse outcomes of conversion to cesarean section?: A retrospective cohort study.

This study aims to investigate the threshold effect of labor duration on adverse outcomes associated with cesarean sections in pregnant women with gestational hypertension and preeclampsia (GH-PE). Th...

Omentin-1 Val109Asp polymorphism and increased coronary artery disease risk in smokers with type 2 diabetes.

Omentin-1 protein has protective effects against coronary artery disease (CAD). The Val109Asp polymorphism (rs2274907) in the Omentin-1 gene has been associated with CAD risk, but this relationship ha...