Serum chloride trajectory and 28-day mortality in critically ill congestive heart failure: A retrospective multicenter cohort study deriving from MIMIC-IV and externally validated.

Congestive heart failure (CHF) is associated with high morbidity, mortality, and substantial economic burden. Although hypochloremia has been linked to adverse outcomes, the relationship between longi...

Association between the advanced lung cancer inflammation index and all-cause mortality in critically ill patients with atrial fibrillation.

Evidence indicates that the advanced lung cancer inflammation index (ALI) is a prognostic tool for patient outcomes across various diseases. Nevertheless, its application in atrial fibrillation (AF) p...

Prevalence and risk factors of potentially inappropriate medications at discharge in older adults with heart failure: A retrospective observational pharmacovigilance study.

Older adults with heart failure (HF) are at high risk of potentially inappropriate medications (PIMs) during hospital discharge, yet real-world data from Asian populations remain limited. This study a...

Exploring associations between epidemiological risk factors and colorectal cancer in Oman: a case-control study.

OBJECTIVES: To identify risk factors and examine associations between colorectal cancer (CRC) status and modifiable and non-modifiable risk factors among patients diagnosed in Oman, considering the ex...

The crucial role of non-specialty local hospitals and clinics in managing advanced stages of adult congenital heart disease in an era of increasing prevalence.

A middle-aged woman with complex congenital heart disease (CHD) and stage D heart failure-including a double outlet univentricular heart-faced difficulty accessing a specialised centre due to dyspnoea...

Ultrafast ultrasound shear wave elastography: a novel approach for assessing myocardial stiffening in congenital aortic stenosis.

BACKGROUND: Congenital aortic stenosis (ConAoS) accounts for approximately 4%-8% of all congenital heart diseases. Chronic pressure overload may result in myocardial stiffening, leading to impaired ca...

Synchronous wearable ultrasound for early detection of coronary and carotid artery comorbidity.

Coronary heart disease (CHD) and carotid artery disease (CAD) often co-occur. However, conventional diagnosis typically involves separate, site-by-site examinations after symptoms appear, leading to d...

Clinical and laboratory characteristics of pediatric patients diagnosed with thyroid hormone resistance: A single-center experience.

BACKGROUND: Thyroid hormone resistance β (RTHβ) is a rare genetic disorder characterized by reduced tissue responsiveness to thyroid hormones. This study aimed to describe the clinical, biochemical, a...

Long-term effects of weight-reducing drugs in people with hypertension.

RATIONALE: Long-term weight management drugs have the potential to reduce body weight and blood pressure in obese or overweight individuals. Being overweight or obese is often associated with hyperten...

Outcomes in laparoscopic versus robotic-assisted surgery for median arcuate ligament syndrome: a systematic review and meta-analysis.

Median Arcuate Ligament Syndrome (MALS) is a rare condition caused by external compression of the coeliac artery by the median arcuate ligament (MAL), leading to postprandial abdominal pain, nausea, v...

Methodological quality of cardiac CT and MRI radiomics studies assessed using METRICS and RQS by human readers and ChatGPT 5.1 Thinking.

OBJECTIVE: To assess the methodological quality of cardiac CT and MRI radiomics studies using the METhodological RadiomICs Score (METRICS) and Radiomics Quality Score (RQS), and to evaluate inter-rate...

Pim1 Mitigates Heart Failure by Suppressing Ferroptosis Via Activation of the mTORC1/SLC7A11/GPX4 Axis.

Heart failure (HF) remains a major cause of morbidity and mortality, with ferroptosis increasingly implicated in its progression. Pim1, a serine/threonine kinase, exerts cardioprotective effects by re...

Beyond the right ventricle: left heart involvement in pulmonary arterial hypertension.

Pulmonary arterial hypertension (PAH) is characterized by progressive remodeling of the pulmonary vasculature, leading to increased pulmonary vascular resistance and chronic right ventricular (RV) pre...

Left ventricular non-compaction in heart failure: contemporary perspective on diagnostic challenges and treatment opportunities.

Left ventricular non-compaction (LVNC) remains one of the most debated phenotypes within the spectrum of cardiomyopathy. Increasing recognition of left ventricular hypertrabeculation (LVHT) in healthy...

Dapagliflozin confers protection against ferroptosis in cardiomyocyte via the inhibition of interferon-gamma pathway.

BACKGROUND: Ferroptosis is reported to have a role in cardiovascular disease (CVD) progression. Recent emerging evidences demonstrate the role of Sodium-Glucose Co-Transporter 2 (SGLT-2) inhibitors in...

Deciphering the potential molecular network underlying nicotine- and its metabolite cotinine-induced myocardial infarction via network toxicology, molecular dynamics, and in vitro experimental validation.

Smoking is a major modifiable risk factor for myocardial infarction (MI); however, the molecular mechanisms through which its core component nicotine and its primary metabolite cotinine mediate MI dev...

DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.

BACKGROUND: Working memory (WM) deficits are frequently observed in patients with insomnia disorder (ID), but their neural basis is unclear. Glymphatic dysfunction and disrupted structural-functional ...

Noninvasive whole-brain imaging of glymphatic dynamics.

Cerebrospinal fluid circulation through the glymphatic system plays a crucial role in removing metabolic waste from the central nervous system. However, the mechanism underlying the brain-wide glympha...

Life-span-dependent transcriptional dynamics of the human heart.

The human heart undergoes continuous transcriptional remodeling from development through aging, yet the cellular and regulatory features governing this process remain incompletely defined. Here, we ge...

Dysfunction of endothelial cells manifests early in pulmonary arterial hypertension and represents a critical therapeutic target. Nevertheless, the limited efficacy of single-target interventions unde...